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Brain Metastases

Brain Metastases

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Clinical trials

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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLCBrain Metastases, Neoplasms by Site, Thoracic Neoplasms, brain disorder, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, central nervous system disorder, lung disorder, lung neoplasm, neoplasm, nervous system disorder, respiratory system disorder, respiratory tract neoplasm, small cell lung carcinomaRecruitingPhase 32026-10-08NCT06457906
Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain MetastasesBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingPhase 22026-10-07NCT05064280
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-activeBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingPhase 22026-10-06NCT06649058
Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal CancersBrain Metastases, Digestive System Diseases, Digestive System Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, digestive system disorder, digestive system neoplasm, esophageal cancer, esophageal disorder, gastric cancer, gastric neoplasm, neoplasm, nervous system disorder, stomach disorderRecruitingNot stated2026-10-05NCT07464470
Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain MetastasesBrain Metastases, Neoplasm Metastasis, Neoplasms by Site, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Skin and Connective Tissue Diseases, brain disorder, breast cancer, breast disorder, breast neoplasm, cancer, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorder, skin disorderNot yet recruitingPhase 12026-10-01NCT07454668
Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain MetastasesBrain Metastases, Neoplasms by Site, Thoracic Neoplasms, brain disorder, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, central nervous system disorder, lung disorder, lung neoplasm, neoplasm, nervous system disorder, respiratory system disorder, respiratory tract neoplasm, small cell lung carcinomaActive, not recruitingNot applicable2026-09-29NCT03391362
Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized TrialBrain Metastases, Disease Attributes, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Recurrence, Skin and Connective Tissue Diseases, Thoracic Neoplasms, Urogenital Diseases, Urogenital Neoplasms, adenocarcinoma, benign urinary system neoplasm, brain disorder, breast disorder, breast neoplasm, carcinoma, central nervous system cancer, central nervous system disorder, epithelial neoplasm, kidney cancer, kidney disorder, lung disorder, lung neoplasm, melanocytic neoplasm, melanoma, neoplasm, nervous system disorder, neuroendocrine neoplasm, primitive neuroectodermal tumor, renal cell carcinoma, respiratory system disorder, respiratory tract neoplasm, skin disorder, skin neoplasm, urinary system disorderActive, not recruitingNot applicable2026-09-29NCT03075072
SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain MetastasesBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingPhase 1 / Phase 22026-09-28NCT04923542
Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)Brain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingPhase 22026-09-22NCT07248228
Feasibility of 18F-Fluciclovine PET/CT to Identify Brain MetastasisBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingEarly phase 12026-09-21NCT06055790
Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)Brain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingPhase 22026-09-18NCT07227610
Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)Brain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingPhase 22026-09-18NCT07053033
A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain MetastasesBrain Metastases, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Urogenital Diseases, Urogenital Neoplasms, adenocarcinoma, benign urinary system neoplasm, brain disorder, carcinoma, central nervous system cancer, central nervous system disorder, epithelial neoplasm, kidney cancer, kidney disorder, neoplasm, nervous system disorder, renal cell carcinoma, urinary system disorderRecruitingPhase 22026-09-18NCT05048212
Neurocognitive Decline in Patients With Brain MetastasesBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderActive, not recruitingPhase 1 / Phase 22026-09-18NCT03508752
Preoperative Embolization for Highly Vascular Brain TumorsBrain Metastases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Nerve Tissue, brain disorder, capillary hemangioma, central nervous system cancer, central nervous system disorder, hemangioblastoma, hemangioma, meningioma, neoplasm, nervous system disorder, tumor of meninges, vascular cancerNot yet recruitingNot applicable2026-09-17NCT07823985
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive MalignanciesBrain Metastases, Digestive System Diseases, Digestive System Neoplasms, Head and Neck Neoplasms, Hemic and Lymphatic Diseases, Neoplasms by Site, Thoracic Neoplasms, brain disorder, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, central nervous system disorder, colonic disorder, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, histiocytosis, intestinal disorder, lung disorder, lung neoplasm, lymphatic system disorder, malignant endocrine neoplasm, neoplasm, nervous system disorder, non-small cell lung carcinoma, rectal disorder, respiratory system disorder, respiratory tract neoplasm, thyroid gland carcinoma, thyroid gland disorder, thyroid tumorRecruitingPhase 1 / Phase 22026-09-16NCT05786924
Development of MRF for Characterization of Brain Tumors After RadiotherapyBrain Metastases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, brain disorder, central nervous system cancer, central nervous system disorder, epithelial neoplasm, glioma, neoplasm, nervous system disorder, neuroepithelial neoplasm, primitive neuroectodermal tumorRecruitingNot applicable2026-09-15NCT06101069
Frameless Stereotactic Radiosurgery for Intact Brain MetastasesBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderRecruitingPhase 22026-09-14NCT02747303
CBF and NCF Changes With Brain RadiationBrain Metastases, Cognition Disorders, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, cognitive disorder, neoplasm, nervous system disorder, psychiatric disorderActive, not recruitingNot stated2026-09-11NCT03606421
IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain MetastasesBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderNot yet recruitingPhase 12026-09-09NCT07569263
Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain MetastasisBrain Metastases, Neoplasms by Site, Thoracic Neoplasms, brain disorder, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, central nervous system disorder, lung disorder, lung neoplasm, neoplasm, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasmRecruitingPhase 22026-09-09NCT06315010
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain MetastasesBrain Metastases, Cancer of Gastrointestinal Tract, Digestive System Diseases, Digestive System Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Skin and Connective Tissue Diseases, Thoracic Neoplasms, brain cancer, brain disorder, breast cancer, breast disorder, breast neoplasm, central nervous system cancer, central nervous system disorder, colonic disorder, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, lung cancer, lung disorder, lung neoplasm, melanocytic neoplasm, melanoma, neoplasm, nervous system disorder, neuroendocrine neoplasm, primitive neuroectodermal tumor, rectal disorder, respiratory system disorder, respiratory tract neoplasm, skin disorder, skin neoplasmRecruitingPhase 22026-09-09NCT04899908
A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)Brain Metastases, Neoplasms by Site, Thoracic Neoplasms, brain disorder, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, central nervous system disorder, lung cancer, lung disorder, lung neoplasm, neoplasm, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasmRecruitingPhase 22026-08-26NCT06822543
University of Kentucky Markey Cancer Center Neuro-Oncology Multi-Disciplinary Tumor Board Protocol for the Treatment of Advanced Brain MetastasesBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorderNot yet recruitingNot applicable2026-08-25NCT07786311
TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain MetastasesBrain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorder, non-small cell lung carcinomaRecruitingPhase 22026-08-25NCT05948813