Lymphohistiocytosis, Hemophagocytic
Lymphohistiocytosis, Hemophagocytic
Explore linked clinical trials. Standard reference: MESH:M002396035 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion | Bone Marrow Failure Disorders, Chronic Disease, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cytopenia, Disease Attributes, Hemic and Lymphatic Diseases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Lymphohistiocytosis, Hemophagocytic, Myeloproliferative Disorders, Neoplasms by Histologic Type, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Primary Immunodeficiency Diseases, acute myeloid leukemia, anemia, aplastic anemia, bone marrow disorder, hematologic disorder, hereditary disease, histiocytosis, immune system disorder, immunoproliferative disorder, inborn error of immunity, inherited hemoglobinopathy, leukemia, lymphatic system disorder, lymphoid leukemia, lymphoma, lymphoproliferative syndrome, myelodysplastic syndrome, myeloid leukemia, neoplasm, non-Langerhans cell histiocytosis | Active, not recruiting | Not applicable | 2026-10-08 | NCT05236764 | |
| Retrospective Study of Immunotherapy Related Toxicities and Factors Impacting Outcomes in Children and Adults With Cancer | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoproliferative syndrome, macrophage activation syndrome, non-Langerhans cell histiocytosis | Active, not recruiting | Not stated | 2026-10-08 | NCT03827343 | |
| Efficacy of Short Course of Intravenous Dexamethasone and Intravenous Immunoglobulin Therapy in Infection-Related Secondary Hemophagocytic Lymphohistiocytosis (isHLH) | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis, secondary hemophagocytic lymphohistiocytosis | Not yet recruiting | Phase 3 | 2026-10-06 | NCT07861776 | |
| Administration of Donor T Cells With the Caspase-9 Suicide Gene | Chronic Disease, DNA Virus Infections, Disease Attributes, Epstein-Barr virus infection, Hemic and Lymphatic Diseases, Herpesviridae infectious disease, Infections, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Lymphohistiocytosis, Hemophagocytic, Myeloproliferative Disorders, Neoplasms by Histologic Type, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Tumor Virus Infections, X-Linked Lymphoproliferative Disorder, acute myeloid leukemia, bone marrow disorder, hematologic disorder, histiocytosis, immune system disorder, immunoproliferative disorder, leukemia, lymphatic system disorder, lymphoid leukemia, lymphoma, lymphoproliferative syndrome, myelodysplastic syndrome, myeloid leukemia, neoplasm, non-Hodgkin lymphoma, non-Langerhans cell histiocytosis, viral infectious disease | Active, not recruiting | Phase 1 | 2026-10-02 | NCT01494103 | |
| Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Recruiting | Phase 2 | 2026-09-21 | NCT06160791 | |
| Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study | Hemic and Lymphatic Diseases, Inflammation, Lymphohistiocytosis, Hemophagocytic, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Shock, Skin and Connective Tissue Diseases, Systemic Inflammatory Response Syndrome, arthritic joint disease, arthropathy, autoimmune disease, connective tissue disorder, cytokine release syndrome, histiocytosis, immune system disorder, immunoproliferative disorder, iron metabolism disease, isolated hyperferritinemia, juvenile idiopathic arthritis, lymphatic system disorder, lymphoproliferative syndrome, macrophage activation syndrome, metabolic disease, musculoskeletal system disorder, non-Langerhans cell histiocytosis, rheumatic disorder, secondary hemophagocytic lymphohistiocytosis | Recruiting | Not stated | 2026-09-10 | NCT06339177 | |
| Establishing a National Egyptian HLH Registry (NEHR) | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, hemophagocytic syndrome, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Recruiting | Not stated | 2026-09-02 | NCT07800234 | |
| CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene | Chronic Disease, Disease Attributes, Hemic and Lymphatic Diseases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Lymphohistiocytosis, Hemophagocytic, Myeloproliferative Disorders, Neoplasms by Histologic Type, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, bone marrow disorder, hematologic disorder, histiocytic sarcoma, histiocytosis, immune system disorder, immunoproliferative disorder, leukemia, lymphatic system disorder, lymphoid leukemia, lymphoma, lymphoproliferative syndrome, malignant histiocytosis, myelodysplastic syndrome, myeloid leukemia, neoplasm, non-Hodgkin lymphoma, non-Langerhans cell histiocytosis | Active, not recruiting | Phase 1 | 2026-07-01 | NCT00710892 | |
| Naive T Cell Deplete Grafts for GVHD Prevention in Non-Malignant Diseases | Bone Marrow Failure, Bone Marrow Failure Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, Primary Immunodeficiency Diseases, bone marrow disorder, hematologic disorder, hereditary disease, histiocytosis, immune system disorder, inborn error of immunity, inherited hemoglobinopathy, lymphatic system disorder, non-Langerhans cell histiocytosis | Not yet recruiting | Phase 2 | 2026-06-22 | NCT07660783 | |
| Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies | Bare Lymphocyte Syndrome, Blood Protein Disorders, Chediak-Higashi syndrome, Chronic Disease, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Cytopenia, DNA repair disease, Disease Attributes, Eye Diseases, Hereditary, Griscelli syndrome, Hemic and Lymphatic Diseases, Histiocytosis, Langerhans-Cell, Infant, Newborn, Diseases, Lymphohistiocytosis, Hemophagocytic, Nutritional and Metabolic Diseases, Omenn syndrome, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Primary Immunodeficiency Diseases, Wiskott-Aldrich syndrome, X-Linked Lymphoproliferative Disorder, X-linked disease, albinism, blood coagulation disease, chronic granulomatous disease, common variable immunodeficiency, dysgammaglobulinemia, eye disorder, hematologic disorder, hemorrhagic disease, hereditary disease, histiocytosis, hyper-IgM syndrome, immune system disorder, immunoproliferative disorder, inborn error of immunity, inherited blood coagulation disorder, interstitial lung disease, leukocyte disorder, leukopenia, lung disorder, lymphatic system disorder, lymphopenia, lymphoproliferative syndrome, metabolic disease, non-Langerhans cell histiocytosis, phagocyte bactericidal dysfunction, respiratory system disorder, reticular dysgenesis, severe combined immunodeficiency | Active, not recruiting | Not applicable | 2026-06-17 | NCT01652092 | |
| All-Trans Retinoic Acid for the Treatment of Hemophagocytic Lymphohistiocytosis | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Not yet recruiting | Phase 2 / Phase 3 | 2026-06-04 | NCT07626398 | |
| Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis | Disease Attributes, Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Recurrence, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Active, not recruiting | Phase 1 / Phase 2 | 2026-04-24 | NCT04551131 | |
| Prospective Cohort for Adult Hemophagocytosis | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Recruiting | Not stated | 2026-04-24 | NCT03117010 | |
| Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic Lymphohistiocytosis | Hemic and Lymphatic Diseases, Inflammation, Lymphohistiocytosis, Hemophagocytic, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Shock, Systemic Inflammatory Response Syndrome, cytokine release syndrome, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Not yet recruiting | Phase 3 | 2026-04-23 | NCT07497438 | |
| Ruxolitinib as First Line Treatment in Primary Haemophagocytic Lymphohistiocytosis (R-HLH) | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Recruiting | Phase 2 | 2026-04-23 | NCT05762640 | |
| Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH) | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, Lymphoma, Extranodal NK-T-Cell, Neoplasms by Histologic Type, T-cell non-Hodgkin lymphoma, histiocytosis, lymphatic system disorder, lymphoma, neoplasm, non-Langerhans cell histiocytosis | Recruiting | Phase 1 / Phase 2 | 2026-04-13 | NCT07525466 | |
| INTO-HLH: A Disease Registry for Patients With Hemophagocytic Lymphohistiocytosis (HLH) | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Recruiting | Not stated | 2026-02-24 | NCT05277272 | |
| Immune Disorder HSCT Protocol | 22q11.2 deletion syndrome, Abnormalities, Multiple, Blood Protein Disorders, Bruton-type agammaglobulinemia, Cardiovascular Abnormalities, Chediak-Higashi syndrome, Chronic Disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, Cytopenia, DNA repair disease, DiGeorge syndrome, Disease Attributes, Eye Diseases, Hereditary, Hemic and Lymphatic Diseases, Infant, Newborn, Diseases, Lymphatic Abnormalities, Lymphohistiocytosis, Hemophagocytic, Musculoskeletal Abnormalities, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Primary Immunodeficiency Diseases, Wiskott-Aldrich syndrome, X-linked disease, albinism, autoimmune disease, autoimmune lymphoproliferative syndrome, blood coagulation disease, cardiovascular disorder, chromosomal disorder, chronic granulomatous disease, common variable immunodeficiency, congenital heart disease, dysgammaglobulinemia, endocrine system disorder, eye disorder, heart disorder, hematologic disorder, hemorrhagic disease, hereditary disease, histiocytosis, hyper-IgM syndrome, hypoparathyroidism, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, immune system disorder, immunoproliferative disorder, inborn error of immunity, inherited blood coagulation disorder, leukocyte disorder, leukopenia, lymphatic system disorder, lymphopenia, lymphoproliferative syndrome, metabolic disease, musculoskeletal system disorder, non-Langerhans cell histiocytosis, parathyroid gland disorder, phagocyte bactericidal dysfunction, severe combined immunodeficiency | Active, not recruiting | Phase 2 | 2026-02-19 | NCT01821781 | |
| Describing Treatment Outcomes and Responses in Lymphoma-associated Hemophagocytic Lymphohistiocytosis | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, Neoplasms by Histologic Type, histiocytosis, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, neoplasm, non-Langerhans cell histiocytosis | Recruiting | Not stated | 2026-01-22 | NCT05898477 | |
| Prospective Single-Arm Clinical Trial of GO Regimen for HLH. | Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, histiocytosis, lymphatic system disorder, non-Langerhans cell histiocytosis | Recruiting | Phase 2 / Phase 3 | 2026-01-14 | NCT07339345 | |
| Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC | Blood Protein Disorders, Bone Diseases, Developmental, Bone Marrow Failure Disorders, Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Chediak-Higashi syndrome, Chronic Disease, Congenital Bone Marrow Failure Syndromes, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Crohn disease, Cytopenia, DNA repair disease, Death, Death, Sudden, Diamond-Blackfan anemia, Digestive System Diseases, Disease Attributes, Eye Diseases, Hereditary, Gaucher disease, Hemic and Lymphatic Diseases, Hereditary Central Nervous System Demyelinating Diseases, Infant Death, Infant, Newborn, Diseases, Krabbe disease, Leukoencephalopathies, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lymphohistiocytosis, Hemophagocytic, Lysosomal Storage Diseases, Nervous System, Mannosidase Deficiency Diseases, Mucopolysaccharidosis I, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Peroxisomal Disorders, Primary Immunodeficiency Diseases, Skin and Connective Tissue Diseases, Sudden Infant Death, Sulfatidosis, Wiskott-Aldrich syndrome, X-linked disease, adrenal gland disorder, adrenocortical insufficiency, adrenoleukodystrophy, albinism, alpha-mannosidosis, anemia, aplastic anemia, arthritic joint disease, arthropathy, autoimmune disease, autoimmune lymphoproliferative syndrome, beta thalassemia, blood coagulation disease, bone disorder, bone marrow disorder, brain disorder, central nervous system disorder, chronic granulomatous disease, connective tissue disorder, cutaneous mucinosis, demyelinating disease, digestive system disorder, disease, dysgammaglobulinemia, endocrine system disorder, eye disorder, familial hemolytic anemia, gastroenteritis, hematologic disorder, hemolytic anemia, hemorrhagic disease, hereditary disease, histiocytosis, hyper-IgM syndrome, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, immune system disorder, immunoproliferative disorder, inborn carbohydrate metabolic disorder, inborn error of immunity, inborn errors of metabolism, inflammatory bowel disease, inherited aplastic anemia, inherited blood coagulation disorder, inherited hemoglobinopathy, inherited neurodegenerative disorder, intellectual disability, intestinal disorder, leukocyte adhesion deficiency 1, leukocyte disorder, leukopenia, lymphatic system disorder, lymphopenia, lymphoproliferative syndrome, lysosomal lipid storage disorder, lysosomal storage disease, metabolic disease, metachromatic leukodystrophy, mucopolysaccharidosis, musculoskeletal system disorder, nervous system disorder, non-Langerhans cell histiocytosis, osteochondrodysplasia, osteopetrosis, osteosclerosis, phagocyte bactericidal dysfunction, pure red-cell aplasia, rheumatic disorder, rheumatoid arthritis, severe combined immunodeficiency, sickle cell disease, sphingolipidosis, syndromic disease, thalassemia | Recruiting | Not stated | 2026-01-13 | NCT04528355 | |
| Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT | Bone Diseases, Developmental, Bone Marrow Failure Disorders, Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Chediak-Higashi syndrome, Chronic Disease, Congenital Abnormalities, Congenital Bone Marrow Failure Syndromes, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Crohn disease, Cytopenia, DNA repair disease, Death, Death, Sudden, Diamond-Blackfan anemia, Digestive System Diseases, Disease Attributes, Eye Diseases, Hereditary, Gaucher disease, Hemic and Lymphatic Diseases, Hereditary Central Nervous System Demyelinating Diseases, Infant Death, Infant, Newborn, Diseases, Krabbe disease, Leukoencephalopathies, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lymphohistiocytosis, Hemophagocytic, Lysosomal Storage Diseases, Nervous System, Mannosidase Deficiency Diseases, Mucopolysaccharidosis I, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Peroxisomal Disorders, Primary Immunodeficiency Diseases, Skin Abnormalities, Skin and Connective Tissue Diseases, Sudden Infant Death, Sulfatidosis, Wiskott-Aldrich syndrome, X-linked disease, adrenal gland disorder, adrenocortical insufficiency, adrenoleukodystrophy, albinism, alpha-mannosidosis, anemia, aplastic anemia, arthritic joint disease, arthropathy, autoimmune disease, autoimmune lymphoproliferative syndrome, beta thalassemia, blood coagulation disease, bone disorder, bone marrow disorder, brain disorder, central nervous system disorder, chronic granulomatous disease, connective tissue disorder, cutaneous mucinosis, demyelinating disease, digestive system disorder, disease, dyskeratosis congenita, endocrine system disorder, eye disorder, familial hemolytic anemia, gastroenteritis, hematologic disorder, hemolytic anemia, hemorrhagic disease, hereditary disease, hereditary skin disorder, histiocytosis, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, immune system disorder, immunoproliferative disorder, inborn carbohydrate metabolic disorder, inborn error of immunity, inborn errors of metabolism, inflammatory bowel disease, inherited aplastic anemia, inherited blood coagulation disorder, inherited hemoglobinopathy, inherited neurodegenerative disorder, intellectual disability, intestinal disorder, juvenile idiopathic arthritis, leukocyte adhesion deficiency 1, leukocyte disorder, leukoencephalopathy, diffuse hereditary, with spheroids 1, leukopenia, lymphatic system disorder, lymphopenia, lymphoproliferative syndrome, lysosomal lipid storage disorder, lysosomal storage disease, metabolic disease, metachromatic leukodystrophy, mucopolysaccharidosis, mucopolysaccharidosis type 2, musculoskeletal system disorder, nervous system disorder, non-Langerhans cell histiocytosis, osteochondrodysplasia, osteopetrosis, osteosclerosis, phagocyte bactericidal dysfunction, pure red-cell aplasia, rheumatic disorder, severe combined immunodeficiency, sickle cell disease, skin disorder, sphingolipidosis, syndromic disease, thalassemia | Recruiting | Phase 2 | 2025-12-15 | NCT01962415 | |
| Zanubrutinib Combined With Rituximab in the Treatment of Secondary HLH in B-cell Lymphoma | B-cell neoplasm, Hemic and Lymphatic Diseases, Lymphohistiocytosis, Hemophagocytic, Neoplasms by Histologic Type, histiocytosis, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, neoplasm, non-Langerhans cell histiocytosis | Recruiting | Phase 4 | 2025-12-08 | NCT07270835 | |
| CytOSorb TreatMent Of Critically Ill PatientS Registry | Acute-On-Chronic Liver Failure, Chemically-Induced Disorders, Digestive System Diseases, Disease Attributes, Drug Misuse, Drug Overdose, Hemic and Lymphatic Diseases, Hepatic Insufficiency, Infarction, Infections, Inflammation, Lymphohistiocytosis, Hemophagocytic, Necrosis, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Postoperative Complications, Postoperative Vasoplegic Syndrome, Prescription Drug Misuse, Respiration Disorders, Rhabdomyolysis, Sepsis, Shock, Shock, Cardiogenic, Systemic Inflammatory Response Syndrome, Vasoplegia, acute liver failure, adult acute respiratory distress syndrome, burn, cardiovascular disorder, cytokine release syndrome, heart disorder, histiocytosis, infectious disease, injury, ischemic disease, liver disorder, liver failure, lung disorder, lymphatic system disorder, muscle tissue disorder, musculoskeletal system disorder, myocardial infarction, myocardial ischemia, non-Langerhans cell histiocytosis, pancreas disorder, pancreatitis, psychiatric disorder, respiratory system disorder, substance-related disorder, toxic shock syndrome, vascular disorder | Recruiting | Not stated | 2025-09-11 | NCT05146336 | |
| CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation | AIDS, Blood-Borne Infections, Bone Marrow Failure Disorders, Congenital Bone Marrow Failure Syndromes, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Diamond-Blackfan anemia, Digestive System Diseases, Familial Hemophagocytic Lymphocytosis, Genital Diseases, HIV infectious disease, Hemic and Lymphatic Diseases, Histiocytosis, Langerhans-Cell, Infections, Kostmann syndrome, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lymphohistiocytosis, Hemophagocytic, Nutritional and Metabolic Diseases, Primary Immunodeficiency Diseases, RNA Virus Infections, Shwachman-Diamond syndrome, Slow Virus Diseases, Urogenital Diseases, anemia, aplastic anemia, bone marrow disorder, exocrine pancreatic insufficiency, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, histiocytosis, immune system disorder, immunoproliferative disorder, inborn error of immunity, infectious disease, inherited aplastic anemia, inherited hemoglobinopathy, interstitial lung disease, lentivirus infection, lipomatosis, lung disorder, lymphatic system disorder, lymphoproliferative syndrome, macrophage activation syndrome, metabolic disease, non-Langerhans cell histiocytosis, pancreas disorder, pure red-cell aplasia, respiratory system disorder, sexually transmitted disease, sickle cell disease, sickle cell-beta-thalassemia disease syndrome, uterine carcinosarcoma, viral infectious disease, viral sexually transmitted disease | Active, not recruiting | Phase 1 / Phase 2 | 2025-08-14 | NCT01966367 |