Frontotemporal Lobar Degeneration
Frontotemporal Lobar Degeneration
Explore linked clinical trials. Standard reference: MESH:M0334714114 results ยท Page 1 of 5
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies | Frontotemporal Lobar Degeneration, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Pathological Conditions, Signs and Symptoms, Pick disease, Signs and Symptoms, TDP-43 proteinopathy, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, eye disorder, frontotemporal dementia, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, ophthalmoplegia, palsy, progressive supranuclear palsy, proteostasis deficiencies, psychiatric disorder, tauopathy | Not yet recruiting | Phase 2 | 2026-10-09 | NCT07868328 | |
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) | Frontotemporal Lobar Degeneration, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, eye disorder, frontotemporal dementia, frontotemporal dementia with motor neuron disease, metabolic disease, motor neuron disorder, movement disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, tauopathy | Recruiting | Not stated | 2026-10-07 | NCT04363684 | |
| Restoring Cervical Lymphatic Drainage in Alzheimer's Disease | Alzheimer disease, Frontotemporal Lobar Degeneration, Pathological Conditions, Anatomical, Pathological Conditions, Signs and Symptoms, Pick disease, Plaque, Amyloid, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Recruiting | Not applicable | 2026-10-02 | NCT07854327 | |
| Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases | Alzheimer disease, Frontotemporal Lobar Degeneration, Lewy body dementia, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, proteostasis deficiencies, psychiatric disorder, synucleinopathy, tauopathy | Recruiting | Not applicable | 2026-10-02 | NCT05326750 | |
| Alzheimer's Disease Neuroimaging Initiative 4 | Alzheimer disease, Cognition Disorders, Cognitive Dysfunction, Frontotemporal Lobar Degeneration, Mild Cognitive Impairment, Pathological Conditions, Anatomical, Pathological Conditions, Signs and Symptoms, Pick disease, Plaque, Amyloid, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Enrolling by invitation | Not stated | 2026-09-29 | NCT05617014 | |
| Transcranial Alternating Current Stimulation in Frontotemporal Dementia | Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, metabolic disease, nervous system disorder, neurodegenerative disease, proteostasis deficiencies, psychiatric disorder | Recruiting | Not applicable | 2026-09-24 | NCT07505784 | |
| Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers | Alzheimer disease, Arterial Occlusive Diseases, Chronic Disease, Cognition Disorders, Cognitive Dysfunction, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Creutzfeldt Jacob disease, Disease Attributes, Dyskinesias, Frontotemporal Lobar Degeneration, Huntington disease, Infections, Leukoencephalopathies, Lewy body dementia, Mixed Dementias, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, TDP-43 proteinopathy, arteriosclerosis disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, central nervous system infectious disorder, cerebrovascular disorder, choreatic disease, cognitive disorder, dementia, hereditary disease, inherited neurodegenerative disorder, intracranial arterial disease, intracranial arteriosclerosis, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, prion disease, proteostasis deficiencies, psychiatric disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Active, not recruiting | Not applicable | 2026-09-21 | NCT05596760 | |
| PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620 | Alzheimer disease, Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, brain disorder, central nervous system disorder, cognitive disorder, dementia, metabolic disease, nervous system disorder, neurodegenerative disease, proteostasis deficiencies, psychiatric disorder, tauopathy | Recruiting | Phase 3 | 2026-09-21 | NCT05456503 | |
| A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia. | Dyssomnias, Frontotemporal Lobar Degeneration, Pathological Conditions, Anatomical, Pathological Conditions, Signs and Symptoms, Pick disease, Plaque, Amyloid, Sleep Disorders, Intrinsic, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, insomnia, nervous system disorder, psychiatric disorder, sleep-wake disorder | Recruiting | Phase 2 | 2026-09-18 | NCT06823752 | |
| Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | Frontotemporal Lobar Degeneration, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, eye disorder, frontotemporal dementia, metabolic disease, motor neuron disorder, movement disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, progressive supranuclear palsy, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, tauopathy | Recruiting | Not stated | 2026-09-17 | NCT03225144 | |
| Alzheimer's Tau Platform: Regimen A - AADvac1 | Alzheimer disease, Frontotemporal Lobar Degeneration, Pick disease, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Enrolling by invitation | Phase 2 | 2026-09-08 | NCT07167966 | |
| Tau PET/CT in Various Tau-Related Disease Patients | Frontotemporal Lobar Degeneration, Nerve Degeneration, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Pick disease, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Recruiting | Not stated | 2026-09-08 | NCT06690983 | |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) | Alzheimer disease, Arterial Occlusive Diseases, Cognition Disorders, Cognitive Dysfunction, Frontotemporal Lobar Degeneration, Leukoencephalopathies, Lewy body dementia, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, TDP-43 proteinopathy, arteriosclerosis disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, disease, frontotemporal dementia, intracranial arterial disease, intracranial arteriosclerosis, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, proteostasis deficiencies, psychiatric disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Not yet recruiting | Not stated | 2026-09-02 | NCT07200739 | |
| Neurodegenerative Diseases Progression Markers (MARKERS-NDD) | Alzheimer disease, Cognition Disorders, Cognitive Dysfunction, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Frontotemporal Lobar Degeneration, Lewy body dementia, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Parkinson disease, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, autonomic nervous system disorder, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, eye disorder, hereditary disease, inherited neurodegenerative disorder, iron metabolism disease, iron poisoning, metabolic disease, motor neuron disorder, movement disorder, multiple system atrophy, nervous system disorder, neuroaxonal dystrophy, neurodegeneration with brain iron accumulation, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, pantothenate kinase-associated neurodegeneration, parkinsonian disorder, primary dysautonomia, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, synucleinopathy, tauopathy | Recruiting | Not stated | 2026-09-02 | NCT06596746 | |
| Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches | Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, amyotrophic lateral sclerosis, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, intracranial hypertension, metabolic disease, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, proteostasis deficiencies, pseudotumor cerebri, psychiatric disorder, spinal cord disorder | Active, not recruiting | Not stated | 2026-08-28 | NCT06856850 | |
| [18F]ACI-19626 PET in TDP-43 Proteinopathies | Alzheimer disease, Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, amyotrophic lateral sclerosis, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, metabolic disease, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, tauopathy | Recruiting | Early phase 1 | 2026-08-26 | NCT06891716 | |
| A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease | Alzheimer disease, Cognition Disorders, Cognitive Dysfunction, Frontotemporal Lobar Degeneration, Pick disease, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Recruiting | Phase 1 | 2026-08-24 | NCT06297590 | |
| AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980) | Alzheimer disease, Frontotemporal Lobar Degeneration, Nerve Degeneration, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, TDP-43 proteinopathy, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, metabolic disease, nervous system disorder, neurodegenerative disease, proteostasis deficiencies, psychiatric disorder, tauopathy | Recruiting | Phase 1 | 2026-08-21 | NCT07158905 | |
| Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD | Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, amyotrophic lateral sclerosis, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, metabolic disease, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, proteostasis deficiencies, psychiatric disorder, spinal cord disorder | Active, not recruiting | Phase 2 | 2026-08-20 | NCT04220021 | |
| Using the EHR to Advance Genomic Medicine Across a Diverse Health System | Alzheimer disease, Aneurysm, Disease Attributes, Frontotemporal Lobar Degeneration, Neoplasms by Histologic Type, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Nutritional and Metabolic Diseases, Parkinson disease, Pathologic Processes, Pathological Conditions, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, aortic aneurysm, aortic disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cognitive disorder, dementia, disease susceptibility, frontotemporal dementia, inherited disease susceptibility, metabolic disease, movement disorder, neoplasm, nervous system disorder, neurodegenerative disease, neuroendocrine neoplasm, neuromuscular disease, paraganglioma, parkinsonian disorder, peripheral nervous system disorder, pheochromocytoma, polyneuropathy, primitive neuroectodermal tumor, proteostasis deficiencies, psychiatric disorder, synucleinopathy, tauopathy, thoracic aortic aneurysm, vascular disorder | Recruiting | Not applicable | 2026-08-14 | NCT06377033 | |
| The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen A: AADvac1 | Frontotemporal Lobar Degeneration, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, cranial nerve neuropathy, dementia, eye disorder, frontotemporal dementia, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, ophthalmoplegia, palsy, proteostasis deficiencies, psychiatric disorder, tauopathy | Enrolling by invitation | Phase 2 | 2026-08-13 | NCT07217665 | |
| A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Recruiting | Phase 1 / Phase 2 | 2026-08-13 | NCT06064890 | |
| The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen B: LM11A-31 | Frontotemporal Lobar Degeneration, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, cranial nerve neuropathy, dementia, eye disorder, frontotemporal dementia, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, ophthalmoplegia, palsy, proteostasis deficiencies, psychiatric disorder, tauopathy | Enrolling by invitation | Phase 2 | 2026-08-12 | NCT07264283 | |
| Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Pick disease, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, nervous system disorder, neurodevelopmental disorder, nominal aphasia, primary progressive aphasia, psychiatric disorder, speech disorder | Recruiting | Not applicable | 2026-08-11 | NCT04957537 | |
| Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study | Alzheimer disease, Arterial Occlusive Diseases, Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Frontotemporal Lobar Degeneration, Huntington disease, Leukoencephalopathies, Lewy body dementia, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Parkinson disease, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, arteriosclerosis disorder, autonomic nervous system disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, choreatic disease, cognitive disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, eye disorder, frontotemporal dementia, hereditary disease, inherited neurodegenerative disorder, intracranial arterial disease, intracranial arteriosclerosis, metabolic disease, motor neuron disorder, movement disorder, multiple system atrophy, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, parkinsonian disorder, primary dysautonomia, progressive supranuclear palsy, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Active, not recruiting | Not stated | 2026-08-10 | NCT06209515 |