Lymphatic Abnormalities
Lymphatic Abnormalities
Explore linked clinical trials. Standard reference: MESH:M044447930 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Neoplasm, Lymphatic Tissue, Neoplasms by Histologic Type, cystic hygroma, lymphangioma, lymphatic system disorder, neoplasm | Recruiting | Phase 2 / Phase 3 | 2026-10-09 | NCT05948943 | |
| A Prospective Natural History Study of Lymphatic Anomalies | Bone Diseases, Developmental, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Osteolysis, Essential, Peritoneal Diseases, bone disorder, bone resorption disease, chylous ascites, digestive system disorder, intestinal disorder, lymphangiectasis, lymphatic system disorder, lymphedema, lytic metastatic bone lesion, musculoskeletal system disorder, protein-losing enteropathy | Recruiting | Not stated | 2026-09-28 | NCT05731141 | |
| A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome | CLOVES syndrome, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, angiomatosis, angioosteohypertrophic syndrome, cardiovascular disorder, lymphatic system disorder, vascular disorder | Recruiting | Phase 3 | 2026-09-21 | NCT07285005 | |
| Lymphatic Anomalies Registry for the Assessment of Outcome Data | Bone Diseases, Developmental, CLOVES syndrome, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Osteolysis, Essential, angiomatosis, angioosteohypertrophic syndrome, blue rubber bleb nevus, bone disorder, bone resorption disease, cardiovascular disorder, kaposiform hemangioendothelioma, kaposiform lymphangiomatosis, lymphatic malformation, lymphatic malformation 12, lymphatic system disorder, lytic metastatic bone lesion, musculoskeletal system disorder, tufted angioma, vascular disorder, vascular malformation | Recruiting | Not stated | 2026-09-10 | NCT02399527 | |
| A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study) | CLOVES syndrome, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, angiomatosis, angioosteohypertrophic syndrome, cardiovascular disorder, lymphatic system disorder, megalencephaly-capillary malformation-polymicrogyria syndrome, vascular disorder, vascular malformation | Recruiting | Phase 2 | 2026-08-25 | NCT06789913 | |
| Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, lymphatic malformation, lymphatic system disorder | Recruiting | Phase 2 | 2026-08-24 | NCT05871970 | |
| Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome | 22q11.2 deletion syndrome, Abnormalities, Multiple, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, DiGeorge syndrome, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Musculoskeletal Abnormalities, cardiovascular disorder, chromosomal disorder, congenital heart disease, endocrine system disorder, heart disorder, hereditary disease, hypoparathyroidism, lymphatic system disorder, musculoskeletal system disorder, parathyroid gland disorder | Recruiting | Not stated | 2026-07-29 | NCT00556530 | |
| Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders | 22q11.2 deletion syndrome, Abnormalities, Multiple, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, DiGeorge syndrome, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Malformations of Cortical Development, Group I, Musculoskeletal Abnormalities, Neoplasms, Multiple Primary, Neurobehavioral Manifestations, Neurologic Manifestations, Sex Chromosome Disorders, Tourette syndrome, X-linked disease, anxiety, anxiety disorder, attention deficit hyperactivity disorder, inattentive type, autism, autism spectrum disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, central nervous system malformation, cerebral cortical dysplasia, chromosomal disorder, congenital heart disease, endocrine system disorder, fragile X syndrome, hamartoma, heart disorder, hereditary disease, hereditary neoplastic syndrome, hypoparathyroidism, inherited neurodegenerative disorder, intellectual disability, lymphatic system disorder, movement disorder, musculoskeletal system disorder, neoplasm, nervous system disorder, neurocutaneous syndrome, neurodegenerative disease, neurodevelopmental disorder, oppositional defiant disorder, parathyroid gland disorder, pervasive developmental disorder, psychiatric disorder, tic disorder, tuberous sclerosis | Recruiting | Phase 2 | 2026-07-27 | NCT06081348 | |
| Parent and Infant Inter(X)Action Intervention (PIXI) | 22q11.2 deletion syndrome, Abnormalities, Multiple, Angelman syndrome, Aortic Stenosis, Supravalvular, Cardiovascular Abnormalities, Chronobiology Disorders, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, DiGeorge syndrome, Down syndrome, Duchenne muscular dystrophy, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Hemic and Lymphatic Diseases, Imprinting Disorders, Klinefelter syndrome, Lymphatic Abnormalities, Male Urogenital Diseases, Malformations of Cortical Development, Group I, Muscular Disorders, Atrophic, Musculoskeletal Abnormalities, Neoplasms, Multiple Primary, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Overweight, Phelan-McDermid syndrome, Prader-Willi syndrome, Rett syndrome, Sex Chromosome Disorders, Smith-Magenis syndrome, Turner syndrome, Urogenital Abnormalities, Urogenital Diseases, Williams syndrome, X-linked disease, aortic valve disorder, aortic valve stenosis, cardiovascular disorder, central nervous system disorder, central nervous system malformation, cerebral cortical dysplasia, chromosomal disorder, congenital heart disease, developmental disability, disorder of sexual differentiation, endocrine system disorder, fragile X syndrome, gonadal disorder, gonadal dysgenesis, hamartoma, heart disorder, heart valve disorder, hereditary disease, hereditary neoplastic syndrome, hypogonadism, hypoparathyroidism, inherited neurodegenerative disorder, intellectual disability, lymphatic system disorder, movement disorder, muscle tissue disorder, muscular dystrophy, musculoskeletal system disorder, neoplasm, nervous system disorder, neurocutaneous syndrome, neurodegenerative disease, neurodevelopmental disorder, neuromuscular disease, nutritional disorder, obesity disorder, overnutrition, parathyroid gland disorder, psychiatric disorder, sex chromosome disorder of sex development, tuberous sclerosis | Enrolling by invitation | Not applicable | 2026-07-13 | NCT03836300 | |
| The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment | 22q11.2 deletion syndrome, Abnormalities, Multiple, Cardiovascular Abnormalities, Chromosome Aberrations, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, DiGeorge syndrome, Down syndrome, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Musculoskeletal Abnormalities, Neurobehavioral Manifestations, Neurologic Manifestations, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Sex Chromosome Aberrations, Trisomy 18 Syndrome, aneuploidy, cardiovascular disorder, chromosomal disorder, congenital heart disease, endocrine system disorder, heart disorder, hereditary disease, hypoparathyroidism, intellectual disability, lymphatic system disorder, musculoskeletal system disorder, nervous system disorder, parathyroid gland disorder, trisomy 13, trisomy 18 | Recruiting | Not stated | 2026-06-12 | NCT07643896 | |
| Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, lymphatic malformation, lymphatic system disorder | Recruiting | Phase 2 | 2026-05-22 | NCT03243019 | |
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) | 22q11.2 deletion syndrome, Abnormalities, Multiple, Blood Protein Disorders, Cardiovascular Abnormalities, Chronic Disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, DNA repair disease, DiGeorge syndrome, Digestive System Diseases, Disease Attributes, Hemic and Lymphatic Diseases, Infant, Newborn, Diseases, Lymphatic Abnormalities, Musculoskeletal Abnormalities, Nutritional and Metabolic Diseases, Omenn syndrome, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Primary Immunodeficiency Diseases, X-linked disease, cardiovascular disorder, chromosomal disorder, chronic granulomatous disease, common variable immunodeficiency, congenital heart disease, digestive system disorder, dysgammaglobulinemia, endocrine system disorder, heart disorder, hematologic disorder, hereditary disease, hyper-IgM syndrome, hypoparathyroidism, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, immune system disorder, inborn error of immunity, intestinal disorder, leukocyte disorder, lymphatic system disorder, metabolic disease, musculoskeletal system disorder, parathyroid gland disorder, phagocyte bactericidal dysfunction, severe combined immunodeficiency | Recruiting | Phase 2 | 2026-05-15 | NCT07284641 | |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations | Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Neoplasm, Lymphatic Tissue, Neoplasms by Histologic Type, PIK3CA-related overgrowth spectrum, Skin and Connective Tissue Diseases, arteriovenous hemangioma/malformation, cardiovascular disorder, cystic hygroma, lymphangioma, lymphatic malformation, lymphatic system disorder, neoplasm, skin disorder, skin vascular disease, vascular disorder, vascular malformation, venous hemangioma | Recruiting | Phase 2 | 2026-05-05 | NCT05983159 | |
| SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations | Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Neoplasm, Lymphatic Tissue, Neoplasms by Histologic Type, cardiovascular disorder, lymphangioma, lymphatic system disorder, microcystic lymphatic malformation, neoplasm, vascular malformation | Active, not recruiting | Phase 3 | 2026-03-27 | NCT06239480 | |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders | 22q11.2 deletion syndrome, Abnormalities, Multiple, Aortic Stenosis, Supravalvular, Brain Damage, Chronic, Brain Injuries, Traumatic, Cardiovascular Abnormalities, Cerebral Palsy, Athetoid, Chromosome Aberrations, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniocerebral Trauma, Craniofacial Abnormalities, DiGeorge syndrome, Down syndrome, Hemic and Lymphatic Diseases, Hypoxia, Hypoxia, Brain, Lymphatic Abnormalities, Musculoskeletal Abnormalities, Neurobehavioral Manifestations, Neurologic Manifestations, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Sex Chromosome Disorders, Signs and Symptoms, Signs and Symptoms, Respiratory, Williams syndrome, X-linked disease, aortic valve disorder, aortic valve stenosis, autism spectrum disorder, brain disorder, brain hypoxia - ischemia, brain injury, brain ischemia, cardiovascular disorder, central nervous system disorder, cerebral palsy, cerebral palsy spastic hemiplegic, cerebrovascular disorder, chromosomal disorder, congenital heart disease, developmental disability, endocrine system disorder, fragile X syndrome, heart disorder, heart valve disorder, hereditary disease, hypoparathyroidism, inherited neurodegenerative disorder, injury, intellectual disability, lymphatic system disorder, musculoskeletal system disorder, nervous system disorder, nervous system injury, neurodevelopmental disorder, parathyroid gland disorder, perinatal asphyxia, pervasive developmental disorder, psychiatric disorder, vascular disorder | Recruiting | Not stated | 2026-03-25 | NCT07493096 | |
| The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome | 22q11.2 deletion syndrome, Abnormalities, Multiple, Aortic Stenosis, Supravalvular, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, DiGeorge syndrome, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Musculoskeletal Abnormalities, Neurobehavioral Manifestations, Neurologic Manifestations, Sex Chromosome Disorders, Williams syndrome, X-linked disease, aortic valve disorder, aortic valve stenosis, cardiovascular disorder, chromosomal disorder, congenital heart disease, endocrine system disorder, fragile X syndrome, heart disorder, heart valve disorder, hereditary disease, hypoparathyroidism, inherited neurodegenerative disorder, intellectual disability, lymphatic system disorder, musculoskeletal system disorder, nervous system disorder, parathyroid gland disorder, velocardiofacial syndrome | Recruiting | Phase 4 | 2026-03-18 | NCT00768820 | |
| Weekly Sirolimus Therapy | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, lymphatic malformation, lymphatic system disorder, venous hemangioma | Recruiting | Phase 2 | 2026-03-05 | NCT04861064 | |
| Immune Disorder HSCT Protocol | 22q11.2 deletion syndrome, Abnormalities, Multiple, Blood Protein Disorders, Bruton-type agammaglobulinemia, Cardiovascular Abnormalities, Chediak-Higashi syndrome, Chronic Disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, Cytopenia, DNA repair disease, DiGeorge syndrome, Disease Attributes, Eye Diseases, Hereditary, Hemic and Lymphatic Diseases, Infant, Newborn, Diseases, Lymphatic Abnormalities, Lymphohistiocytosis, Hemophagocytic, Musculoskeletal Abnormalities, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Primary Immunodeficiency Diseases, Wiskott-Aldrich syndrome, X-linked disease, albinism, autoimmune disease, autoimmune lymphoproliferative syndrome, blood coagulation disease, cardiovascular disorder, chromosomal disorder, chronic granulomatous disease, common variable immunodeficiency, congenital heart disease, dysgammaglobulinemia, endocrine system disorder, eye disorder, heart disorder, hematologic disorder, hemorrhagic disease, hereditary disease, histiocytosis, hyper-IgM syndrome, hypoparathyroidism, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, immune system disorder, immunoproliferative disorder, inborn error of immunity, inherited blood coagulation disorder, leukocyte disorder, leukopenia, lymphatic system disorder, lymphopenia, lymphoproliferative syndrome, metabolic disease, musculoskeletal system disorder, non-Langerhans cell histiocytosis, parathyroid gland disorder, phagocyte bactericidal dysfunction, severe combined immunodeficiency | Active, not recruiting | Phase 2 | 2026-02-19 | NCT01821781 | |
| A Prospective Study on the Treatment of cLM Based on ICG Imaging | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, lymphatic malformation, lymphatic system disorder | Recruiting | Not applicable | 2026-02-18 | NCT06275022 | |
| European Registry Study on Lymphatic Interventions | Chylothorax, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, digestive system disorder, intestinal disorder, lymphatic system disorder, plastic bronchitis, pleural disorder, protein-losing enteropathy, respiratory system disorder | Recruiting | Not stated | 2026-01-21 | NCT07131293 | |
| Injection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic Malformations | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, lymphatic system disorder | Not yet recruiting | Phase 2 | 2026-01-06 | NCT07320001 | |
| Using Transcranial Alternating Current Stimulation to Improve Executive Function in 22q11.2 Deletion Syndrome | 22q11.2 deletion syndrome, Abnormalities, Multiple, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Musculoskeletal Abnormalities, cardiovascular disorder, chromosomal disorder, congenital heart disease, endocrine system disorder, heart disorder, hereditary disease, hypoparathyroidism, lymphatic system disorder, musculoskeletal system disorder, parathyroid gland disorder | Recruiting | Not applicable | 2025-12-02 | NCT05664412 | |
| Understanding of Psychotic Disorders in Children With 22q11.2DS | 22q11.2 deletion syndrome, Abnormalities, Multiple, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniofacial Abnormalities, DiGeorge syndrome, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Musculoskeletal Abnormalities, cardiovascular disorder, chromosomal disorder, congenital heart disease, endocrine system disorder, heart disorder, hereditary disease, hypoparathyroidism, lymphatic system disorder, musculoskeletal system disorder, parathyroid gland disorder | Recruiting | Not applicable | 2025-07-30 | NCT04639388 | |
| Diagnostic Imaging of Vascular Malformations Using MSOT and ULM | Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, arteriovenous hemangioma/malformation, cardiovascular disorder, lymphatic malformation, lymphatic system disorder, vascular disorder, vascular malformation | Not yet recruiting | Not stated | 2025-06-22 | NCT06994260 | |
| Institution of an Italian Registry and Biobank for Biological Sample Collection | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Neoplasm, Lymphatic Tissue, Neoplasms by Histologic Type, lymphangioma, lymphatic malformation, lymphatic system disorder, neoplasm | Recruiting | Not applicable | 2025-03-25 | NCT06892964 |