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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
EEG-Guided Transcranial Magnetic Stimulation for Adults With DepressionDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderNot yet recruitingNot applicable2026-10-07NCT07862205
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical TrialDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderActive, not recruitingPhase 22026-10-06NCT06480500
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant ResponseDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingPhase 22026-10-05NCT07284667
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingPhase 22026-10-05NCT06511908
iTBS Versus Standard 10 Hz rTMS for Treatment-Resistant Depression (TRD)Depressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderActive, not recruitingNot applicable2026-10-01NCT07852065
Natural History of Depression, Bipolar Disorder and Suicide RiskBipolar and Related Disorders, Depression, Bipolar, Depressive Disorder, Treatment-Resistant, bipolar disorder, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingNot stated2026-10-01NCT06462196
Long-term Observation of Participants With Mood DisordersDepressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderRecruitingNot stated2026-10-01NCT04877977
Regulated Stimulation for Optimized Network Activity and Therapeutic EquilibriumDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingNot applicable2026-09-29NCT07594483
Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat DepressionDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingNot applicable2026-09-29NCT06773949
Dehydroepiandrosterone (DHEA) as Augmentation of Standard Antidepressants in Treatment-resistant Depression.Depressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderRecruitingPhase 32026-09-28NCT07843927
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant DepressionDepressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderRecruitingPhase 32026-09-25NCT07716098
Ketogenic Diet and Neuromodulation in Treatment Resistant DepressionDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderNot yet recruitingNot applicable2026-09-25NCT07376018
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS TrialDepressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderNot yet recruitingPhase 2 / Phase 32026-09-25NCT07227103
Ketamine-Assisted Psychotherapy for Treatment-Resistant DepressionChronic Pain, Depressive Disorder, Treatment-Resistant, Neurologic Manifestations, Pain, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, depressive disorder, mood disorder, psychiatric disorderNot yet recruitingPhase 22026-09-24NCT07247006
Biomarker-Guided Antidepressant SelectionDepressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderRecruitingPhase 42026-09-23NCT07680140
Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant DepressionDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderNot yet recruitingNot applicable2026-09-22NCT07834762
DBS for TRD With the Medtronic Percept PCDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingNot applicable2026-09-22NCT05773755
Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to TreatmentBipolar and Related Disorders, Depressive Disorder, Treatment-Resistant, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Schizophrenia Spectrum and Other Psychotic Disorders, Signs and Symptoms, anxiety disorder, bipolar disorder, catatonia, depressive disorder, mood disorder, nervous system disorder, obsessive-compulsive disorder, psychiatric disorder, schizophreniaRecruitingNot applicable2026-09-21NCT07741981
Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)Depressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderRecruitingPhase 22026-09-21NCT07210112
ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive DisorderDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingNot applicable2026-09-18NCT07474974
Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan TrialDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderNot yet recruitingNot applicable2026-09-18NCT07043738
Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD)Depressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderActive, not recruitingNot applicable2026-09-18NCT06236711
Ketamine Treatment for Treatment-Resistant Depression - the Role of FramingDepressive Disorder, Treatment-Resistant, depressive disorder, mood disorder, psychiatric disorderNot yet recruitingNot applicable2026-09-17NCT07824973
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for DepressionBipolar and Related Disorders, Depressive Disorder, Treatment-Resistant, bipolar disorder, depressive disorder, mood disorder, psychiatric disorderActive, not recruitingNot stated2026-09-17NCT06002204
Lumateperone for Late-Life DepressionDepressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorderRecruitingPhase 32026-09-16NCT07623135