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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
Gene Therapy Trial for Otoferlin Gene-mediated Hearing LossDeafness, Deafness, Autosomal Recessive 9, Ear Diseases, Hearing Loss, Bilateral, Hearing Loss, Sensorineural, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, auditory neuropathy, hearing disorder, hearing loss disorder, nervous system disorder, otorhinolaryngologic diseaseRecruitingPhase 32026-09-29NCT05821959
Genetic Study of OTOF- Related Auditory Neuropathy Spectrum DisorderDeafness, Autosomal Recessive 9, Ear Diseases, Hearing Loss, Hidden, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, auditory neuropathy, hearing disorder, hearing loss disorder, nervous system disorder, otorhinolaryngologic diseaseNot yet recruitingNot stated2026-08-21NCT07778641
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin MutationsDeafness, Autosomal Recessive 9, Ear Diseases, Hearing Loss, Sensorineural, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, auditory neuropathy, hearing disorder, hearing loss disorder, nervous system disorder, otorhinolaryngologic diseaseRecruitingPhase 1 / Phase 22026-08-05NCT05788536
A Phase I/II Clinical Trial With SENS-501 in Children Suffering From Severe to Profound Hearing Loss Due to Otoferlin (OTOF) MutationsDeafness, Deafness, Autosomal Recessive 9, Ear Diseases, Hearing Loss, Sensorineural, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, hearing disorder, hearing loss disorder, nervous system disorder, otorhinolaryngologic diseaseActive, not recruitingPhase 1 / Phase 22026-07-08NCT06370351
Long Term Follow-up Study of AAVAnc80-hOTOF Gene TherapyDeafness, Deafness, Autosomal Recessive 9, Ear Diseases, Hearing Loss, Bilateral, Hearing Loss, Sensorineural, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, auditory neuropathy, hearing disorder, hearing loss disorder, nervous system disorder, otorhinolaryngologic diseaseEnrolling by invitationNot stated2026-04-06NCT06696456