Acute-On-Chronic Liver Failure
Acute-On-Chronic Liver Failure
Explore linked clinical trials. Standard reference: MESH:M058861543 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Very Low-volume Plasma Exchange in ACLF | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Not yet recruiting | Not applicable | 2026-10-05 | NCT07857434 | |
| A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device. | Acute-On-Chronic Liver Failure, Digestive System Diseases, Fibrosis, Hepatic Insufficiency, Pathologic Processes, Pathological Conditions, Signs and Symptoms, acute liver failure, cirrhosis of liver, liver disorder, liver failure | Recruiting | Not applicable | 2026-09-22 | NCT07347275 | |
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure | Acute-On-Chronic Liver Failure, Brain Diseases, Metabolic, Digestive System Diseases, Hepatic Insufficiency, Nutritional and Metabolic Diseases, acute liver failure, brain disorder, central nervous system disorder, hepatic encephalopathy, liver disorder, liver failure, metabolic disease, nervous system disorder | Not yet recruiting | Phase 1 / Phase 2 | 2026-09-21 | NCT07429838 | |
| A-TANGO Phase 2 Study | Acute-On-Chronic Liver Failure, Chemically-Induced Disorders, Digestive System Diseases, Fibrosis, Hepatic Insufficiency, Pathologic Processes, Pathological Conditions, Signs and Symptoms, acute liver failure, alcohol-induced disorders, alcohol-related disorders, alcoholic hepatitis, alcoholic liver cirrhosis, alcoholic liver disease, cirrhosis of liver, hepatitis, liver disorder, liver failure, substance-related disorder | Recruiting | Phase 2 | 2026-09-21 | NCT06890039 | |
| Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, Infections, Inflammation, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Sepsis, Systemic Inflammatory Response Syndrome, acute liver failure, liver disorder, liver failure | Recruiting | Not applicable | 2026-09-11 | NCT06562803 | |
| A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial). | Acute-On-Chronic Liver Failure, Digestive System Diseases, Fibrosis, Hepatic Insufficiency, Pathologic Processes, Pathological Conditions, Signs and Symptoms, acute liver failure, cirrhosis of liver, liver disorder, liver failure | Recruiting | Phase 2 | 2026-09-11 | NCT05895136 | |
| Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver Failure | Acute-On-Chronic Liver Failure, Digestive System Diseases, Fibrosis, Hepatic Insufficiency, Pathologic Processes, Pathological Conditions, Signs and Symptoms, acute liver failure, chronic liver failure, cirrhosis of liver, liver disorder, liver failure | Not yet recruiting | Not stated | 2026-07-29 | NCT07734896 | |
| Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Recruiting | Phase 2 | 2026-07-17 | NCT06916585 | |
| Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Not yet recruiting | Phase 2 | 2026-07-09 | NCT07694297 | |
| Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Recruiting | Not applicable | 2026-07-07 | NCT06831565 | |
| The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Recruiting | Not applicable | 2026-06-16 | NCT05030571 | |
| Precise Profiling of Liver Disease Patients With DPMAS Therapy, Treating Optimal Patients and Achieving Hard Endpoint (PADSTONE Study) | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Active, not recruiting | Not stated | 2026-05-26 | NCT05129904 | |
| Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Not yet recruiting | Not applicable | 2026-05-18 | NCT07593638 | |
| COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device | Acute-On-Chronic Liver Failure, Atrophy, Digestive System Diseases, Hepatic Insufficiency, Neurologic Manifestations, Neuromuscular Manifestations, Pathological Conditions, Anatomical, Pathological Conditions, Signs and Symptoms, Sarcopenia, Signs and Symptoms, acute liver failure, liver disorder, liver failure, muscular atrophy, nervous system disorder | Recruiting | Not applicable | 2026-05-01 | NCT06079021 | |
| Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, Infections, Inflammation, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Sepsis, Shock, Systemic Inflammatory Response Syndrome, acute liver failure, liver disorder, liver failure, toxic shock syndrome | Not yet recruiting | Not applicable | 2026-03-25 | NCT07184866 | |
| Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial) | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, Infections, Inflammation, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Sepsis, Systemic Inflammatory Response Syndrome, acute liver failure, liver disorder, liver failure | Not yet recruiting | Not applicable | 2026-03-25 | NCT07178366 | |
| Predictors of Decompensation, Acute-on-chronic Liver Failure and Mortality in Liver Cirrhosis | Acute-On-Chronic Liver Failure, Death, Digestive System Diseases, Fibrosis, Hepatic Insufficiency, Pathologic Processes, Pathological Conditions, Signs and Symptoms, acute liver failure, liver disorder, liver failure | Recruiting | Not stated | 2026-02-27 | NCT07438288 | |
| Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure. | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Not yet recruiting | Not applicable | 2026-02-20 | NCT07422948 | |
| PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Active, not recruiting | Early phase 1 | 2026-02-13 | NCT07409259 | |
| Risk Factors Affecting MSC Efficacy in ACLF Patients | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Recruiting | Not stated | 2025-11-28 | NCT07198854 | |
| F573 for Injection for the Treatment of Liver Injury/Failure | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Recruiting | Phase 2 | 2025-11-19 | NCT05689645 | |
| Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs | Acute-On-Chronic Liver Failure, Digestive System Diseases, Fibrosis, Hepatic Insufficiency, Pathologic Processes, Pathological Conditions, Signs and Symptoms, acute liver failure, cirrhosis of liver, liver disorder, liver failure | Recruiting | Not stated | 2025-10-20 | NCT04613921 | |
| CytOSorb TreatMent Of Critically Ill PatientS Registry | Acute-On-Chronic Liver Failure, Chemically-Induced Disorders, Digestive System Diseases, Disease Attributes, Drug Misuse, Drug Overdose, Hemic and Lymphatic Diseases, Hepatic Insufficiency, Infarction, Infections, Inflammation, Lymphohistiocytosis, Hemophagocytic, Necrosis, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Postoperative Complications, Postoperative Vasoplegic Syndrome, Prescription Drug Misuse, Respiration Disorders, Rhabdomyolysis, Sepsis, Shock, Shock, Cardiogenic, Systemic Inflammatory Response Syndrome, Vasoplegia, acute liver failure, adult acute respiratory distress syndrome, burn, cardiovascular disorder, cytokine release syndrome, heart disorder, histiocytosis, infectious disease, injury, ischemic disease, liver disorder, liver failure, lung disorder, lymphatic system disorder, muscle tissue disorder, musculoskeletal system disorder, myocardial infarction, myocardial ischemia, non-Langerhans cell histiocytosis, pancreas disorder, pancreatitis, psychiatric disorder, respiratory system disorder, substance-related disorder, toxic shock syndrome, vascular disorder | Recruiting | Not stated | 2025-09-11 | NCT05146336 | |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Not yet recruiting | Phase 1 | 2025-08-28 | NCT07131540 | |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial | Acute-On-Chronic Liver Failure, Digestive System Diseases, Hepatic Insufficiency, acute liver failure, liver disorder, liver failure | Not yet recruiting | Phase 2 | 2025-08-20 | NCT07131306 |