undifferentiated pleomorphic sarcoma
undifferentiated pleomorphic sarcoma
Explore linked clinical trials. Standard reference: MONDO:000214220 results · Page 1 of 1
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, liposarcoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 2 | 2026-10-09 | NCT07741877 | |
| Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Active, not recruiting | Phase 2 | 2026-10-09 | NCT05836571 | |
| Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, liposarcoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 3 | 2026-10-07 | NCT06422806 | |
| Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Active, not recruiting | Phase 2 | 2026-09-25 | NCT02923778 | |
| Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, liposarcoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Not yet recruiting | Phase 2 | 2026-09-15 | NCT07802652 | |
| SBRT Combined With Reduced-Dose Anthracycline Chemotherapy and Toripalimab as Neoadjuvant Therapy for Localized High-Risk Undifferentiated Pleomorphic Sarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Not yet recruiting | Phase 2 | 2026-09-14 | NCT07817095 | |
| Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, liposarcoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Active, not recruiting | Phase 2 | 2026-09-14 | NCT03307616 | |
| Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, dermatofibrosarcoma protuberans, fibrosarcoma, histiocytoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, sarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 1 | 2026-09-04 | NCT05711615 | |
| A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors | Digestive System Diseases, Digestive System Neoplasms, Head and Neck Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Thoracic Neoplasms, bronchial neoplasm, bronchogenic carcinoma, carcinoma, colonic disorder, colorectal neoplasm, connective tissue neoplasm, dermatofibrosarcoma protuberans, digestive system disorder, digestive system neoplasm, epithelial neoplasm, fibrosarcoma, gastric neoplasm, head and neck squamous cell carcinoma, histiocytoma, intestinal disorder, leiomyosarcoma, liposarcoma, lung disorder, lung neoplasm, myomatous neoplasm, neoplasm, non-small cell lung carcinoma, rectal disorder, respiratory system disorder, respiratory tract neoplasm, sarcoma, solitary fibrous tumor, squamous cell carcinoma, stomach disorder, undifferentiated pleomorphic sarcoma | Recruiting | Phase 1 | 2026-06-11 | NCT06789172 | |
| LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas | Adnexal Diseases, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Skin and Connective Tissue Diseases, Urogenital Diseases, Urogenital Neoplasms, bone disorder, bone giant cell tumor, bone sarcoma, breast disorder, breast neoplasm, carcinoma, connective tissue neoplasm, dedifferentiated chondrosarcoma, endocrine system disorder, epithelial neoplasm, female reproductive system disorder, female reproductive system neoplasm, giant cell tumor, gonadal disorder, histiocytoma, malignancy in giant cell tumor of bone, malignant endocrine neoplasm, musculoskeletal system disorder, neoplasm, osteosarcoma, ovarian cancer, ovarian carcinosarcoma, ovarian disorder, poorly differentiated thyroid gland carcinoma, sarcoma, skin disorder, thyroid gland squamous cell carcinoma, thyroid gland undifferentiated (anaplastic) carcinoma, triple-negative breast carcinoma, undifferentiated high grade pleomorphic sarcoma of bone, undifferentiated pleomorphic sarcoma | Active, not recruiting | Phase 2 | 2026-05-22 | NCT03449108 | |
| A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, alveolar soft part sarcoma, connective tissue neoplasm, dermatofibrosarcoma protuberans, fibrosarcoma, histiocytoma, myomatous neoplasm, myxofibrosarcoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 2 | 2026-04-23 | NCT04332874 | |
| Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Neoplasms, Nerve Tissue, connective tissue neoplasm, dermatofibrosarcoma protuberans, fibrosarcoma, histiocytoma, leiomyosarcoma, malignant giant cell tumor of soft parts, myomatous neoplasm, myxofibrosarcoma, neoplasm, nerve sheath neoplasm, nervous system disorder, neurofibroma, neurofibrosarcoma, neuromuscular disease, peripheral nervous system disorder, peripheral nervous system neoplasm, pleomorphic rhabdomyosarcoma, sarcoma, synovial sarcoma, undifferentiated high grade pleomorphic sarcoma of bone, undifferentiated pleomorphic sarcoma, undifferentiated pleomorphic sarcoma, inflammatory variant | Active, not recruiting | Phase 1 | 2026-03-10 | NCT04420975 | |
| Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas | Disease Attributes, Disease Progression, Ewing sarcoma, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Pathologic Complete Response, Pathologic Processes, Pathological Conditions, Signs and Symptoms, angiosarcoma, bone disorder, bone sarcoma, chondrosarcoma, connective tissue neoplasm, histiocytoma, leiomyosarcoma, musculoskeletal system disorder, myomatous neoplasm, neoplasm, osteosarcoma, sarcoma, undifferentiated pleomorphic sarcoma, vascular cancer | Recruiting | Not applicable | 2026-02-17 | NCT04055220 | |
| Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, dermatofibrosarcoma protuberans, fibrosarcoma, histiocytoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, myxofibrosarcoma, neoplasm, pleomorphic rhabdomyosarcoma, sarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 2 | 2026-01-28 | NCT07173972 | |
| Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, dermatofibrosarcoma protuberans, fibrosarcoma, histiocytoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, pleomorphic rhabdomyosarcoma, sarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 2 | 2026-01-28 | NCT07169344 | |
| Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas | Ewing sarcoma, Neoplasms by Histologic Type, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, neoplasm, osteosarcoma, sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 2 | 2025-10-07 | NCT05182164 | |
| MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma | Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Malignant Peripheral Nerve Sheath Tumors, Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Neoplasms, Nerve Tissue, Urogenital Diseases, Urogenital Neoplasms, angiosarcoma, connective tissue neoplasm, desmoplastic small round cell tumor, endometrial stromal tumor, endometrioid stromal sarcoma, endometrium neoplasm, female reproductive system disorder, female reproductive system neoplasm, fibrosarcoma, histiocytoma, leiomyosarcoma, liposarcoma, mixed neoplasm, myomatous neoplasm, neoplasm, nerve sheath neoplasm, nervous system disorder, neurofibroma, neurofibrosarcoma, neuromuscular disease, peripheral nervous system disorder, peripheral nervous system neoplasm, pleomorphic rhabdomyosarcoma, sarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma, uterine disorder, vascular cancer | Recruiting | Phase 2 | 2025-07-24 | NCT06277154 | |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma | Metastatic Dermatofibrosarcoma Protuberans, Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Neoplasms, Nerve Tissue, adult pleomorphic rhabdomyosarcoma, alveolar soft part sarcoma, angiosarcoma, clear cell sarcoma, connective tissue neoplasm, dermatofibrosarcoma protuberans, extraskeletal Ewing sarcoma, extraskeletal myxoid chondrosarcoma, fibrosarcoma, histiocytoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, myxofibrosarcoma, neoplasm, nerve sheath neoplasm, nervous system disorder, neurofibroma, neurofibrosarcoma, neuromuscular disease, peripheral nervous system disorder, peripheral nervous system neoplasm, round cell sarcoma with EWSR1-non-ETS fusion, sarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma, vascular cancer | Not yet recruiting | Not applicable | 2024-07-30 | NCT06526897 | |
| Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma Patients | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, angiosarcoma, connective tissue neoplasm, histiocytoma, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma, vascular cancer | Recruiting | Phase 2 | 2023-07-27 | NCT05961761 | |
| Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas | Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, bone angiosarcoma, bone disorder, bone neoplasm, bone sarcoma, chondroblastic osteosarcoma, connective tissue neoplasm, conventional osteosarcoma, extraosseous osteosarcoma, fibrosarcomatous osteosarcoma, high grade surface osteosarcoma, histiocytoma, juxtacortical osteosarcoma, low grade central osteosarcoma, musculoskeletal system disorder, neoplasm, osteoblastic osteosarcoma, osteosarcoma, periosteal osteogenic sarcoma, sarcoma, small cell osteogenic sarcoma, telangiectatic osteogenic sarcoma, undifferentiated pleomorphic sarcoma | Not yet recruiting | Not stated | 2022-08-25 | NCT05515068 |