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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
Registry Maastro ApplicatorDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal cancer, rectal disorder, rectal neoplasmRecruitingNot stated2026-10-09NCT07501845
An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal cancer, rectal disorder, rectal neoplasmRecruitingNot applicable2026-10-09NCT05914766
DETECT: Target Volume for Rectal Endoluminal Radiation BoostingDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal cancer, rectal disorder, rectal neoplasmRecruitingNot stated2026-10-09NCT04927897
COQ10 and Vitamin E for Off-Target Radiation ToxicityAnal Cancer, Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Male Urogenital Diseases, Neoplasms by Site, Urogenital Diseases, Urogenital Neoplasms, Uterine Cervical Neoplasms, anus disorder, anus neoplasm, cervix disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, female reproductive system disorder, female reproductive system neoplasm, intestinal disorder, male reproductive organ cancer, male reproductive system disorder, neoplasm, prostate cancer, prostate disorder, rectal disorder, rectal neoplasm, uterine cancer, uterine disorderNot yet recruitingPhase 1 / Phase 22026-10-08NCT07668284
ColoSeal™ ICD System Anastomotic Protection Pivotal StudyDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasmActive, not recruitingNot applicable2026-10-08NCT07429110
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)Digestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colon adenocarcinoma, colonic disorder, colonic neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasm, rectum adenocarcinomaRecruitingPhase 32026-10-07NCT06997497
SMP-3124LP in Adults With Advanced Solid TumorsDigestive System Diseases, Digestive System Neoplasms, Head and Neck Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Skin and Connective Tissue Diseases, Thoracic Neoplasms, anus disorder, anus neoplasm, breast disorder, breast neoplasm, bronchial neoplasm, bronchogenic carcinoma, carcinoma, colorectal neoplasm, digestive system disorder, digestive system neoplasm, epithelial neoplasm, head and neck squamous cell carcinoma, intestinal disorder, lung disorder, lung neoplasm, neoplasm, non-small cell lung carcinoma, rectal disorder, rectal neoplasm, respiratory system disorder, respiratory tract neoplasm, skin disorder, squamous cell carcinoma, triple-negative breast carcinomaRecruitingPhase 1 / Phase 22026-10-07NCT06526819
Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal CancerAnal Cancer, Digestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, anus disorder, anus neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasmRecruitingPhase 22026-10-07NCT06493019
Young-Onset Colorectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colon adenocarcinoma, colonic disorder, colonic neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasm, rectum adenocarcinomaActive, not recruitingNot stated2026-10-07NCT02863107
A Prospective, Biomarker-Stratified Phase 2 Study: β-Hydroxybutyrate as a Predictive Biomarker for Short-Course Radiotherapy Followed by Chemotherapy Plus PD-1 Inhibitor Versus Chemotherapy Alone in Locally Advanced Rectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal cancer, rectal disorder, rectal neoplasmNot yet recruitingPhase 22026-10-06NCT07847229
Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant TherapyDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasm, rectum adenocarcinomaRecruitingPhase 22026-10-06NCT06569368
A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer PatientsDigestive System Diseases, Digestive System Neoplasms, Low Anterior Resection Syndrome, Neoplasms by Site, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Postoperative Complications, colonic disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal carcinoma, rectal disorder, rectal neoplasmRecruitingNot applicable2026-10-06NCT06424522
E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated CancersAnal Cancer, Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Head and Neck Neoplasms, Male Urogenital Diseases, Neoplasms by Site, Otorhinolaryngologic Neoplasms, Pharyngeal Diseases, Stomatognathic Diseases, Urogenital Diseases, Urogenital Neoplasms, Uterine Cervical Neoplasms, anus disorder, anus neoplasm, cervix disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, female reproductive system disorder, female reproductive system neoplasm, human papillomavirus-related penile squamous cell carcinoma, human papillomavirus-related squamous cell carcinoma, intestinal disorder, male reproductive organ cancer, male reproductive system disorder, neoplasm, otorhinolaryngologic disease, penile cancer, penile disorder, penile neoplasm, rectal disorder, rectal neoplasm, uterine disorder, vaginal cancer, vaginal disorder, vulva cancer, vulvar diseaseRecruitingPhase 1 / Phase 22026-10-06NCT05639972
Evaluating Novel Therapies in ctDNA Positive GI CancersDigestive System Diseases, Digestive System Neoplasms, Liver Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, adenocarcinoma, carcinoma, colon adenocarcinoma, colonic disorder, colonic neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, epithelial neoplasm, gallbladder adenocarcinoma, gastric adenocarcinoma, hepatocellular carcinoma, intestinal disorder, liver disorder, neoplasm, pancreatic adenocarcinoma, rectal disorder, rectal neoplasm, rectum adenocarcinomaActive, not recruitingPhase 32026-10-06NCT05482516
Epidemiology of Anal Human Papillomavirus Carriage in Female Solid Organ Transplant Recipients With More Than 10 Years of ImmunosuppressionDNA Virus Infections, Digestive System Diseases, Digestive System Neoplasms, Disease Attributes, Genital Diseases, Infections, Neoplasms by Site, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Tumor Virus Infections, Urogenital Diseases, anus disorder, anus neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, human papilloma virus infection, infectious disease, intestinal disorder, neoplasm, rectal disorder, rectal neoplasm, sexually transmitted disease, viral infectious disease, viral sexually transmitted diseaseNot yet recruitingNot applicable2026-10-05NCT07858201
Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001Digestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal cancer, rectal disorder, rectal neoplasmRecruitingPhase 22026-10-05NCT05254327
Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)Adnexal Diseases, Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Skin and Connective Tissue Diseases, Urogenital Diseases, Urogenital Neoplasms, adenocarcinoma, benign urinary system neoplasm, breast cancer, breast disorder, breast neoplasm, carcinoma, colonic disorder, colonic neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, endometrium neoplasm, epithelial neoplasm, female reproductive system disorder, female reproductive system neoplasm, gonadal disorder, intestinal disorder, kidney cancer, kidney disorder, male reproductive organ cancer, male reproductive system disorder, malignant colon neoplasm, malignant endocrine neoplasm, neoplasm, ovarian cancer, ovarian disorder, prostate cancer, prostate disorder, rectal cancer, rectal disorder, rectal neoplasm, renal cell carcinoma, skin disorder, urinary bladder cancer, urinary bladder disorder, urinary bladder neoplasm, urinary system disorder, uterine disorderActive, not recruitingNot applicable2026-10-05NCT05056077
Therapy Adapted for High Risk and Low Risk HIV-Associated Anal CancerBlood-Borne Infections, Digestive System Diseases, Digestive System Neoplasms, Genital Diseases, HIV infectious disease, Infections, Neoplasms by Site, RNA Virus Infections, Urogenital Diseases, anal margin squamous cell carcinoma, anal squamous cell carcinoma, anus disorder, anus neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, immune system disorder, inborn error of immunity, infectious disease, intestinal disorder, lentivirus infection, neoplasm, rectal disorder, rectal neoplasm, sexually transmitted disease, squamous cell carcinoma of rectum, uterine carcinosarcoma, viral infectious disease, viral sexually transmitted diseaseActive, not recruitingPhase 22026-10-05NCT04929028
LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colonic disorder, colonic neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasmActive, not recruitingPhase 1 / Phase 22026-10-05NCT04616183
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment DelaysDigestive System Diseases, Digestive System Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Neoplasms by Site, appendiceal neoplasm, appendix carcinoma, carcinoma of esophagus, carcinoma of the ampulla of vater, cecal disorder, cecal neoplasm, colon carcinoma, colonic disorder, colonic neoplasm, colorectal neoplasm, digestive system cancer, digestive system disorder, digestive system neoplasm, esophageal disorder, gastric carcinoma, gastric neoplasm, intestinal disorder, neoplasm, rectal carcinoma, rectal disorder, rectal neoplasm, small intestine carcinoma, stomach disorderRecruitingNot applicable2026-10-02NCT07283939
ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal cancer, rectal disorder, rectal neoplasmRecruitingPhase 32026-10-02NCT07188025
Family Communications After Genetic TestingDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colon adenocarcinoma, colonic disorder, colonic neoplasm, colorectal adenocarcinoma, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasm, rectum adenocarcinomaRecruitingNot applicable2026-10-02NCT07143487
Distance-Based Exercise to Preserve Function and Prevent DisabilityAdnexal Diseases, Anal Cancer, Biliary Tract Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Esophageal Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Head and Neck Neoplasms, Liver Neoplasms, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Connective and Soft Tissue, Skin and Connective Tissue Diseases, Thoracic Neoplasms, Urogenital Diseases, Urogenital Neoplasms, Uterine Cervical Neoplasms, anus disorder, anus neoplasm, benign urinary system neoplasm, biliary tract disorder, breast cancer, breast disorder, breast neoplasm, cervix disorder, colonic disorder, colonic neoplasm, colorectal neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, endometrium neoplasm, esophageal cancer, esophageal disorder, female reproductive system disorder, female reproductive system neoplasm, gallbladder disorder, gallbladder neoplasm, gastric cancer, gastric neoplasm, gonadal disorder, head and neck cancer, intestinal disorder, kidney cancer, kidney disorder, liver cancer, liver disorder, lung cancer, lung disorder, lung neoplasm, male reproductive organ cancer, male reproductive system disorder, malignant colon neoplasm, malignant endocrine neoplasm, malignant pancreatic neoplasm, neoplasm, ovarian cancer, ovarian disorder, pancreas disorder, pancreatic neoplasm, prostate cancer, prostate disorder, rectal cancer, rectal disorder, rectal neoplasm, respiratory system disorder, respiratory tract neoplasm, sarcoma, skin disorder, stomach disorder, urinary system disorder, uterine disorderRecruitingNot applicable2026-10-02NCT07059884
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid TumorsAdnexal Diseases, Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Male Urogenital Diseases, Neoplasm Metastasis, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Skin and Connective Tissue Diseases, Thoracic Neoplasms, Urogenital Diseases, Urogenital Neoplasms, adenocarcinoma, anus disorder, anus neoplasm, benign urinary system neoplasm, breast disorder, breast neoplasm, bronchial neoplasm, bronchogenic carcinoma, carcinoma, cholangiocarcinoma, colonic disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, endometrium neoplasm, epithelial neoplasm, female reproductive system disorder, female reproductive system neoplasm, gonadal disorder, intestinal disorder, kidney cancer, kidney disorder, lung disorder, lung neoplasm, malignant endocrine neoplasm, melanocytic neoplasm, melanoma, neoplasm, neuroendocrine neoplasm, non-small cell lung carcinoma, ovarian cancer, ovarian disorder, primitive neuroectodermal tumor, rectal disorder, rectal neoplasm, renal cell carcinoma, respiratory system disorder, respiratory tract neoplasm, skin disorder, skin neoplasm, transitional cell carcinoma, triple-negative breast carcinoma, urinary system disorder, uterine disorderRecruitingPhase 12026-10-02NCT06270706
A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colon adenocarcinoma, colonic disorder, colonic neoplasm, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasm, rectum adenocarcinomaNot yet recruitingPhase 22026-10-01NCT07691489