leiomyosarcoma
leiomyosarcoma
Explore linked clinical trials. Standard reference: MONDO:000505840 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, sarcoma | Recruiting | Phase 1 / Phase 2 | 2026-10-07 | NCT06975293 | |
| Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, retroperitoneal sarcoma, sarcoma | Recruiting | Phase 3 | 2026-10-07 | NCT04031677 | |
| Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, pancreatic adenocarcinoma, sarcoma | Active, not recruiting | Phase 2 | 2026-10-05 | NCT03851614 | |
| Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Recruiting | Phase 2 | 2026-10-01 | NCT06528769 | |
| Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, sarcoma | Recruiting | Phase 1 / Phase 2 | 2026-09-29 | NCT06498648 | |
| A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Active, not recruiting | Phase 1 | 2026-09-25 | NCT06308419 | |
| Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, histiocytoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, sarcoma, undifferentiated pleomorphic sarcoma | Active, not recruiting | Phase 2 | 2026-09-25 | NCT02923778 | |
| Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, dermatofibrosarcoma protuberans, fibrosarcoma, histiocytoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, sarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma | Recruiting | Phase 1 | 2026-09-04 | NCT05711615 | |
| A Study of Ivonescimab in People With Leiomyosarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Recruiting | Phase 2 | 2026-08-27 | NCT07516925 | |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Metastatic Dermatofibrosarcoma Protuberans, Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Neoplasms, Nerve Tissue, Urogenital Abnormalities, Urogenital Diseases, Well Differentiated Liposarcoma, angiosarcoma, clear cell sarcoma, connective tissue neoplasm, dermatofibrosarcoma protuberans, disorder of sexual differentiation, endocrine system disorder, epithelioid hemangioendothelioma, extraskeletal myxoid chondrosarcoma, fibrosarcoma, glomus tumor, gonadal disorder, granular cell cancer, granular cell tumor, hemangioendothelioma, hemangioma, histiocytoma, Angiomatoid fibrous, inflammatory leiomyosarcoma, intimal sarcoma, leiomyosarcoma, liposarcoma, low grade fibromyxoid sarcoma, malignant myoepithelioma, malignant perineurioma, mixed neoplasm, myoepithelial tumor, myomatous neoplasm, myxofibrosarcoma, myxoid liposarcoma, neoplasm, nerve sheath neoplasm, nervous system disorder, neurofibroma, neurofibrosarcoma, neuromuscular disease, osteosarcoma, peripheral nervous system disorder, peripheral nervous system neoplasm, sarcoma, synovial sarcoma, undifferentiated (embryonal) sarcoma, vascular cancer | Recruiting | Phase 1 / Phase 2 | 2026-08-03 | NCT06239272 | |
| A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic Therapy | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Recruiting | Phase 1 | 2026-07-31 | NCT07633756 | |
| Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors | Carcinoma, Ductal, Ewing sarcoma, Hemic and Lymphatic Diseases, Myosarcoma, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Ductal, Lobular, and Medullary, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Skin and Connective Tissue Diseases, adenocarcinoma, basal cell carcinoma, basal cell neoplasm, carcinoma, connective tissue neoplasm, endocrine gland neoplasm, endocrine system disorder, epithelial neoplasm, glioma, immune system disorder, immunoproliferative disorder, leiomyosarcoma, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, malignant endocrine neoplasm, melanocytic neoplasm, melanoma, myomatous neoplasm, neoplasm, neuroendocrine neoplasm, neuroepithelial neoplasm, osteosarcoma, primitive neuroectodermal tumor, rhabdomyosarcoma, sarcoma, skin disorder, skin neoplasm, squamous cell carcinoma, squamous cell neoplasm, transitional cell carcinoma | Recruiting | Early phase 1 | 2026-07-31 | NCT07628634 | |
| A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases | DNA Virus Infections, Epstein-Barr virus infection, Hemic and Lymphatic Diseases, Herpesviridae infectious disease, Infections, Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Tumor Virus Infections, immune system disorder, immunoproliferative disorder, inborn error of immunity, leiomyosarcoma, lymphatic system disorder, lymphoproliferative syndrome, myomatous neoplasm, neoplasm, sarcoma, viral infectious disease | Active, not recruiting | Phase 2 | 2026-07-31 | NCT04554914 | |
| AOH1996 for the Treatment of Refractory Solid Tumors | Adnexal Diseases, Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Thoracic Neoplasms, Urogenital Diseases, Urogenital Neoplasms, bronchial neoplasm, bronchogenic carcinoma, connective tissue neoplasm, endocrine system disorder, female reproductive system disorder, female reproductive system neoplasm, gonadal disorder, leiomyosarcoma, lung disorder, lung neoplasm, malignant endocrine neoplasm, malignant pancreatic neoplasm, myomatous neoplasm, neoplasm, non-small cell lung carcinoma, osteosarcoma, ovarian cancer, ovarian disorder, pancreas disorder, pancreatic neoplasm, respiratory system disorder, respiratory tract neoplasm, sarcoma, synovial sarcoma | Recruiting | Phase 1 | 2026-07-28 | NCT05227326 | |
| A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Active, not recruiting | Phase 2 | 2026-07-17 | NCT04624178 | |
| Localized Leiomyosarcoma Biomarker Protocol | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Recruiting | Not stated | 2026-07-02 | NCT04925089 | |
| Metastatic Leiomyosarcoma Biomarker Protocol | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Recruiting | Not stated | 2026-06-24 | NCT05653388 | |
| XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma | Ewing sarcoma, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, bone disorder, bone sarcoma, connective tissue neoplasm, leiomyosarcoma, musculoskeletal system disorder, myomatous neoplasm, neoplasm, osteosarcoma, sarcoma, synovial sarcoma | Recruiting | Phase 2 | 2026-06-18 | NCT06571734 | |
| Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo) | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Active, not recruiting | Phase 3 | 2026-06-18 | NCT06088290 | |
| A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors | Digestive System Diseases, Digestive System Neoplasms, Head and Neck Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Thoracic Neoplasms, bronchial neoplasm, bronchogenic carcinoma, carcinoma, colonic disorder, colorectal neoplasm, connective tissue neoplasm, dermatofibrosarcoma protuberans, digestive system disorder, digestive system neoplasm, epithelial neoplasm, fibrosarcoma, gastric neoplasm, head and neck squamous cell carcinoma, histiocytoma, intestinal disorder, leiomyosarcoma, liposarcoma, lung disorder, lung neoplasm, myomatous neoplasm, neoplasm, non-small cell lung carcinoma, rectal disorder, respiratory system disorder, respiratory tract neoplasm, sarcoma, solitary fibrous tumor, squamous cell carcinoma, stomach disorder, undifferentiated pleomorphic sarcoma | Recruiting | Phase 1 | 2026-06-11 | NCT06789172 | |
| Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS) | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, sarcoma | Active, not recruiting | Phase 2 | 2026-05-22 | NCT03114527 | |
| Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, leiomyosarcoma, myomatous neoplasm, neoplasm, sarcoma | Active, not recruiting | Phase 2 | 2026-05-01 | NCT04200443 | |
| Agnostic Therapy in Rare Solid Tumors | Adnexal Diseases, Biliary Tract Neoplasms, Carcinoma, Ovarian Epithelial, DNA Virus Infections, Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Head and Neck Neoplasms, Herpesviridae infectious disease, Infections, Kaposi's sarcoma, MIT family translocation renal cell carcinoma, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, Neuroectodermal Tumors, Primitive, Peripheral, Parathyroid Neoplasms, Pregnancy Complications, Neoplastic, Sertoli-Leydig cell tumor, Sex Cord-Gonadal Stromal Tumors, Urogenital Diseases, Urogenital Neoplasms, adenocarcinoma, adenoid cystic carcinoma, adenoma, adrenal gland cancer, adrenal gland disorder, angiosarcoma, anus disorder, anus neoplasm, apocrine adenocarcinoma, benign urinary system neoplasm, biliary tract disorder, bladder urachal adenocarcinoma, bladder urachal carcinoma, breast secretory carcinoma, capillary hemangioma, carcinoma, carcinosarcoma, cholangiocarcinoma, colorectal neoplasm, connective tissue neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, epithelial neoplasm, fallopian tube disorder, fallopian tube neoplasm, female reproductive system disorder, female reproductive system neoplasm, fibrolamellar hepatocellular carcinoma, fibrosarcoma, gallbladder disorder, gallbladder neoplasm, gonadal disorder, gonadal tissue neoplasm, granulosa cell tumor, hemangioblastoma, hemangioma, hepatoblastoma, intestinal disorder, leiomyosarcoma, male reproductive organ cancer, male reproductive system disorder, malignant endocrine neoplasm, mesonephric neoplasm, mesothelial neoplasm, mesothelioma, metaplastic breast carcinoma, mixed neoplasm, myomatous neoplasm, neoplasm, nerve sheath neoplasm, nervous system disorder, neuroblastoma, neuroendocrine neoplasm, neuroepithelial neoplasm, neurofibroma, neurofibrosarcoma, neuromuscular disease, osteosarcoma, ovarian cancer, ovarian disorder, parathyroid gland carcinoma, parathyroid gland disorder, penile disorder, penile neoplasm, peripheral nervous system disorder, peripheral nervous system neoplasm, pregnancy disorder, primitive neuroectodermal tumor, rectal disorder, rectal neoplasm, sarcoma, testicular cancer, testicular disorder, thyroid gland disorder, thyroid tumor, trophoblastic neoplasm, urethra neoplasm, urethral disorder, urinary system disorder, vaginal cancer, vaginal disorder, vascular cancer, viral infectious disease, vulva cancer, vulvar disease, yolk sac tumor | Recruiting | Phase 2 | 2026-04-15 | NCT06638931 | |
| Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, Neoplasms, Nerve Tissue, connective tissue neoplasm, dermatofibrosarcoma protuberans, fibrosarcoma, histiocytoma, leiomyosarcoma, malignant giant cell tumor of soft parts, myomatous neoplasm, myxofibrosarcoma, neoplasm, nerve sheath neoplasm, nervous system disorder, neurofibroma, neurofibrosarcoma, neuromuscular disease, peripheral nervous system disorder, peripheral nervous system neoplasm, pleomorphic rhabdomyosarcoma, sarcoma, synovial sarcoma, undifferentiated high grade pleomorphic sarcoma of bone, undifferentiated pleomorphic sarcoma, undifferentiated pleomorphic sarcoma, inflammatory variant | Active, not recruiting | Phase 1 | 2026-03-10 | NCT04420975 | |
| Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients | Liposarcoma, Dedifferentiated, Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, angiosarcoma, leiomyosarcoma, liposarcoma, myomatous neoplasm, neoplasm, retroperitoneal sarcoma, sarcoma, vascular cancer | Recruiting | Not stated | 2026-02-25 | NCT07432932 |