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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive CrisisCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Hemic and Lymphatic Diseases, Male Urogenital Diseases, Respiration Disorders, Urogenital Diseases, Vaso-Occlusive Crises, acute chest syndrome, acute kidney injury, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, kidney disorder, kidney failure, lung disorder, respiratory system disorder, sickle cell disease, urinary system disorderRecruitingPhase 22026-10-08NCT06699849
Natural History of Sickle Cell DiseaseCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Respiration Disorders, acute chest syndrome, anemia, cardiovascular disorder, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, hypertensive disorder, inherited hemoglobinopathy, lung disorder, pulmonary hypertension, respiratory system disorder, sickle cell disease, vascular disorderRecruitingNot stated2026-09-16NCT00081523
Tocilizumab for Acute Chest SyndromeCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Respiration Disorders, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell diseaseRecruitingPhase 22026-09-15NCT05640271
Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell DiseaseCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Respiration Disorders, Signs and Symptoms, Vaso-Occlusive Crises, acute chest syndrome, agnosia, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, nervous system disorder, perceptual disorders, respiratory system disorder, sickle cell diseaseRecruitingPhase 32026-09-09NCT07274254
Pleuropulmonary Ultrasound Imaging in Patients With Sickle Cell Disease in a Vaso-occlusive Crisis. "ECHODREP"Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Emergencies, Hemic and Lymphatic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Respiration Disorders, Vaso-Occlusive Crises, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell diseaseNot yet recruitingNot stated2026-08-24NCT07782489
CPAP for Hypoxemic Acute Chest Syndrome in Sickle Cell DiseaseCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Respiration Disorders, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell diseaseNot yet recruitingNot applicable2026-07-23NCT07703566
Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell DiseaseCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Respiration Disorders, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell diseaseRecruitingPhase 32026-06-24NCT06818266
Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive CareCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Respiration Disorders, Vaso-Occlusive Crises, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell diseaseRecruitingNot applicable2026-03-10NCT07246265
Awake Prone Positioning for Severe Acute Chest SyndromeCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Respiration Disorders, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell diseaseNot yet recruitingNot applicable2025-09-02NCT06698120