Down syndrome
Down syndrome
Explore linked clinical trials. Standard reference: MONDO:0008608111 results ยท Page 1 of 5
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome | Abnormalities, Multiple, Apnea, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Dyssomnias, Neurobehavioral Manifestations, Neurologic Manifestations, Respiration Disorders, Sleep Disorders, Intrinsic, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, obstructive sleep apnea syndrome, respiratory system disorder, sleep apnea syndrome, sleep-wake disorder | Not yet recruiting | Not applicable | 2026-10-07 | NCT07658053 | |
| Escalating Doses of Memantine in Down Syndrome (MEDS-123) | Abnormalities, Multiple, Alzheimer disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, chromosomal disorder, cognitive disorder, dementia, hereditary disease, intellectual disability, nervous system disorder, neurodegenerative disease, neurodevelopmental disorder, psychiatric disorder, tauopathy | Not yet recruiting | Phase 1 | 2026-10-05 | NCT07531940 | |
| Vascular Function in Adults With Down Syndrome | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Recruiting | Not stated | 2026-10-02 | NCT07630207 | |
| A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia | Abnormalities, Multiple, B-cell neoplasm, Burkitt lymphoma, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Virus Infections, Down syndrome, Epstein-Barr virus infection, Hemic and Lymphatic Diseases, Herpesviridae infectious disease, Infections, Neoplasms by Histologic Type, Neurobehavioral Manifestations, Neurologic Manifestations, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Tumor Virus Infections, chromosomal disorder, hematologic disorder, hereditary disease, immune system disorder, immunoproliferative disorder, intellectual disability, leukemia, lymphatic system disorder, lymphoid leukemia, lymphoma, lymphoproliferative syndrome, neoplasm, nervous system disorder, viral infectious disease | Active, not recruiting | Phase 3 | 2026-10-01 | NCT03914625 | |
| Down Syndrome Obstructive Sleep Apnea | Abnormalities, Multiple, Apnea, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Dyssomnias, Neurobehavioral Manifestations, Neurologic Manifestations, Respiration Disorders, Sleep Disorders, Intrinsic, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, obstructive sleep apnea syndrome, respiratory system disorder, sleep apnea syndrome, sleep-wake disorder | Recruiting | Phase 2 | 2026-09-30 | NCT06043440 | |
| Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, autonomic nervous system disorder, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, primary dysautonomia | Recruiting | Phase 3 | 2026-09-28 | NCT07238465 | |
| An Open-Label Phase II Feasibility Study for the Use of Ublituximab in Adults With Down Syndrome Regression Disorder | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Not yet recruiting | Phase 2 | 2026-09-23 | NCT07812181 | |
| Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) | Abnormalities, Multiple, Apnea, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Dyssomnias, Neurobehavioral Manifestations, Neurologic Manifestations, Respiration Disorders, Sleep Disorders, Intrinsic, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, obstructive sleep apnea syndrome, respiratory system disorder, sleep apnea syndrome, sleep-wake disorder | Recruiting | Not applicable | 2026-09-11 | NCT05508971 | |
| Hematological Profile in Children With Numerical Chromosomal Disorders | Abnormalities, Multiple, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Klinefelter syndrome, Male Urogenital Diseases, Neurobehavioral Manifestations, Neurologic Manifestations, Sex Chromosome Disorders, Trisomy 18 Syndrome, Turner syndrome, Urogenital Abnormalities, Urogenital Diseases, cardiovascular disorder, chromosomal disorder, congenital heart disease, disorder of sexual differentiation, endocrine system disorder, gonadal disorder, gonadal dysgenesis, heart disorder, hereditary disease, hypogonadism, intellectual disability, nervous system disorder, sex chromosome disorder of sex development, trisomy 18 | Not yet recruiting | Not stated | 2026-09-10 | NCT07807540 | |
| Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy | Abnormalities, Multiple, Chromosome Aberrations, Chromosome Duplication, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, Pathologic Processes, Pathological Conditions, Signs and Symptoms, aneuploidy, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, trisomy | Recruiting | Not stated | 2026-09-09 | NCT01429389 | |
| A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD) | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Recruiting | Phase 2 | 2026-09-04 | NCT07636811 | |
| Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1 | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Recruiting | Phase 2 | 2026-09-03 | NCT07598643 | |
| HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome | Abnormalities, Multiple, Body Weight, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Overweight, Pathological Conditions, Signs and Symptoms, Pediatric Obesity, Signs and Symptoms, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, nutritional disorder, obesity disorder, overnutrition | Active, not recruiting | Not applicable | 2026-09-03 | NCT07296861 | |
| Endotype DIrected Treatment for OSA in Down Syndrome | Abnormalities, Multiple, Apnea, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Dyssomnias, Neurobehavioral Manifestations, Neurologic Manifestations, Respiration Disorders, Sleep Disorders, Intrinsic, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, obstructive sleep apnea syndrome, respiratory system disorder, sleep apnea syndrome, sleep-wake disorder | Recruiting | Phase 4 | 2026-09-03 | NCT07280468 | |
| A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) | Abnormalities, Multiple, B-cell neoplasm, Burkitt lymphoma, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DNA Virus Infections, Down syndrome, Epstein-Barr virus infection, Hemic and Lymphatic Diseases, Herpesviridae infectious disease, Infections, Neoplasms by Histologic Type, Neurobehavioral Manifestations, Neurologic Manifestations, Tumor Virus Infections, chromosomal disorder, hereditary disease, immune system disorder, immunoproliferative disorder, intellectual disability, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, neoplasm, nervous system disorder, viral infectious disease | Recruiting | Phase 2 | 2026-09-01 | NCT04546399 | |
| Executive Function Play Opportunities for Children With Down Syndrome | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Not yet recruiting | Not applicable | 2026-08-28 | NCT07792382 | |
| Pilot Evaluation of the Developed Syntactic-Semantic Visual Configuration Intervention for Children With Language Impairment | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, autism, autism spectrum disorder, chromosomal disorder, communication disorder, hereditary disease, intellectual disability, language disorder, nervous system disorder, neurodevelopmental disorder, pervasive developmental disorder, psychiatric disorder | Not yet recruiting | Not applicable | 2026-08-26 | NCT07786545 | |
| Effect of Sensory Integration on Gross and Balance on Children With Down Syndrome | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Recruiting | Not applicable | 2026-08-25 | NCT07785011 | |
| A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, myeloid leukemia associated with down syndrome, nervous system disorder | Recruiting | Not stated | 2026-08-25 | NCT05702645 | |
| Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea | Abnormalities, Multiple, Apnea, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Dyssomnias, Neurobehavioral Manifestations, Neurologic Manifestations, Respiration Disorders, Sleep Disorders, Intrinsic, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder, obstructive sleep apnea syndrome, respiratory system disorder, sleep apnea syndrome, sleep-wake disorder | Active, not recruiting | Not applicable | 2026-08-25 | NCT04801771 | |
| Vestibular Stimulation Versus Foot Intrinsic Muscle Exercises in Children With Down Syndrome | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Not yet recruiting | Not applicable | 2026-08-21 | NCT07778654 | |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) | Abnormalities, Multiple, Arrhythmias, Cardiac, COVID-19, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Coronaviridae Infections, Down syndrome, Dyssomnias, Edema, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Hemic and Lymphatic Diseases, Hemorrhage, Infant, Newborn, Diseases, Infant, Premature, Diseases, Infections, Inflammation, Kawasaki disease, Lung Injury, Menorrhagia, Menstruation Disturbances, Neurobehavioral Manifestations, Neurologic Manifestations, Nidovirales infectious disease, Nutritional and Metabolic Diseases, Orthocoronavirinae infectious disease, Pain, Pathologic Processes, Pathological Conditions, Signs and Symptoms, RNA Virus Infections, Signs and Symptoms, Skin and Connective Tissue Diseases, Sleep Disorders, Intrinsic, Suppuration, Urogenital Diseases, Uterine Hemorrhage, Ventilator-Induced Lung Injury, Water-Electrolyte Imbalance, adrenal gland disorder, adrenal gland hyperfunction, adrenocortical insufficiency, attention deficit hyperactivity disorder, inattentive type, blood coagulation disease, bronchopulmonary dysplasia, cardiovascular disorder, cellulitis, chromosomal disorder, coagulation protein disease, connective tissue disorder, endocrine system disorder, female reproductive system disorder, heart disorder, heart failure, hematologic disorder, hemophilia A, hemorrhagic disease, hereditary disease, hyperaldosteronism, hyperphosphatemia, hypertensive disorder, inherited blood coagulation disorder, insomnia, intellectual disability, lung disorder, lymphatic system disorder, metabolic disease, nervous system disorder, neurodevelopmental disorder, oppositional defiant disorder, pediatric multisystem inflammatory disease, COVID-19 related, phosphorus metabolism disease, pneumonia, potassium deficiency disease, primary aldosteronism, psychiatric disorder, pulmonary arterial hypertension, pulmonary hypertension, respiratory system disorder, respiratory tract infectious disorder, skin disorder, skin disorder caused by infection, skin infection, skin vascular disease, sleep-wake disorder, uterine disorder, vascular disorder, vascular hemostatic disease, vasculitis, viral infectious disease, viral pneumonia | Recruiting | Not stated | 2026-08-21 | NCT04278404 | |
| NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Not yet recruiting | Phase 1 | 2026-08-19 | NCT07278492 | |
| Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia | Abnormalities, Multiple, Airway Obstruction, Apnea, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Dyssomnias, Muscle Hypertonia, Nasal Obstruction, Neurobehavioral Manifestations, Neurologic Manifestations, Neuromuscular Manifestations, Pathological Conditions, Signs and Symptoms, Respiration Disorders, Signs and Symptoms, Signs and Symptoms, Respiratory, Sleep Disorders, Intrinsic, chromosomal disorder, hereditary disease, intellectual disability, nasal disorder, nervous system disorder, obstructive sleep apnea syndrome, otorhinolaryngologic disease, psychiatric disorder, respiratory failure, respiratory system disorder, sleep apnea syndrome, sleep-wake disorder | Recruiting | Not applicable | 2026-08-19 | NCT05527652 | |
| Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Hemic and Lymphatic Diseases, Myeloproliferative Disorders, Neoplasms by Histologic Type, Neurobehavioral Manifestations, Neurologic Manifestations, acute myeloid leukemia, bone marrow disorder, chromosomal disorder, hematologic disorder, hereditary disease, intellectual disability, leukemia, myelodysplastic syndrome, myeloid leukemia, myeloid leukemia associated with down syndrome, myeloproliferative neoplasm, neoplasm, nervous system disorder | Active, not recruiting | Phase 3 | 2026-08-19 | NCT02521493 |