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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES SyndromeCLOVES syndrome, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, angiomatosis, angioosteohypertrophic syndrome, cardiovascular disorder, lymphatic system disorder, vascular disorderRecruitingPhase 32026-09-21NCT07285005
Lymphatic Anomalies Registry for the Assessment of Outcome DataBone Diseases, Developmental, CLOVES syndrome, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, Osteolysis, Essential, angiomatosis, angioosteohypertrophic syndrome, blue rubber bleb nevus, bone disorder, bone resorption disease, cardiovascular disorder, kaposiform hemangioendothelioma, kaposiform lymphangiomatosis, lymphatic malformation, lymphatic malformation 12, lymphatic system disorder, lytic metastatic bone lesion, musculoskeletal system disorder, tufted angioma, vascular disorder, vascular malformationRecruitingNot stated2026-09-10NCT02399527
A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)CLOVES syndrome, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Lymphatic Abnormalities, angiomatosis, angioosteohypertrophic syndrome, cardiovascular disorder, lymphatic system disorder, megalencephaly-capillary malformation-polymicrogyria syndrome, vascular disorder, vascular malformationRecruitingPhase 22026-08-25NCT06789913
Safety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the PeripheryCLOVES syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, angiomatosis, angioosteohypertrophic syndrome, blindness (disorder), blue rubber bleb nevus, cardiovascular disorder, cortical blindness, eye disorder, nervous system disorder, vascular disorder, vision disorderActive, not recruitingNot applicable2026-02-19NCT06642051
Identification of Biomarkers for Patients with Vascular AnomaliesBone Diseases, Developmental, CLOVES syndrome, Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Osteolysis, Essential, angiomatosis, angioosteohypertrophic syndrome, bone disorder, bone resorption disease, cardiovascular disorder, diffuse lymphatic malformation, kaposiform hemangioendothelioma, kaposiform lymphangiomatosis, lytic metastatic bone lesion, musculoskeletal system disorder, vascular disorder, vascular malformationRecruitingNot stated2024-11-06NCT03001180