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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut SyndromeCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorder, visual epilepsyRecruitingPhase 32026-10-09NCT05066217
Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGSCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epilepsies, Myoclonic, Epilepsy, Generalized, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorderEnrolling by invitationNot applicable2026-10-08NCT07225231
Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut SyndromeCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorderNot yet recruitingNot applicable2026-10-07NCT07568860
A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGSCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorderNot yet recruitingPhase 42026-09-24NCT07728097
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Epilepsies, Myoclonic, Epilepsy, Generalized, Epileptic Syndromes, Lennox-Gastaut syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, developmental and epileptic encephalopathy, epilepsy, hereditary disease, nervous system disorder, neurodevelopmental disorder, psychiatric disorder, visual epilepsyEnrolling by invitationPhase 32026-09-15NCT06908226
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, developmental and epileptic encephalopathy, epilepsy, hereditary disease, nervous system disorder, neurodevelopmental disorder, psychiatric disorder, visual epilepsyActive, not recruitingPhase 32026-09-15NCT06719141
RNS System LGS Feasibility StudyCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Seizures, Generalized, Signs and Symptoms, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorder, visual epilepsyActive, not recruitingPhase 22026-09-15NCT05339126
A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to EpidiolexCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epilepsies, Myoclonic, Epilepsy, Generalized, Epileptic Syndromes, Lennox-Gastaut syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorder, visual epilepsyNot yet recruitingPhase 42026-09-11NCT06924827
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral SolutionCongenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, Epilepsies, Myoclonic, Epilepsy, Generalized, Epileptic Syndromes, Fibrosis, Lennox-Gastaut syndrome, Malformations of Cortical Development, Group I, Neoplasms, Multiple Primary, Pathologic Processes, Pathological Conditions, Signs and Symptoms, brain disorder, central nervous system disorder, central nervous system malformation, cerebral cortical dysplasia, cirrhosis of liver, epilepsy, hamartoma, hereditary disease, hereditary neoplastic syndrome, inherited neurodegenerative disorder, liver disorder, neoplasm, nervous system disorder, neurocutaneous syndrome, neurodegenerative disease, tuberous sclerosisActive, not recruitingPhase 42026-08-26NCT05044819
EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine TreatmentCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorderEnrolling by invitationNot stated2026-08-06NCT07555171
Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut SyndromeCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorder, visual epilepsyRecruitingNot stated2026-08-06NCT05374824
Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALYCongenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Epilepsies, Myoclonic, Epilepsy, Generalized, Epileptic Syndromes, Lennox-Gastaut syndrome, Malformations of Cortical Development, Group I, Neoplasms, Multiple Primary, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, central nervous system malformation, cerebral cortical dysplasia, epilepsy, hamartoma, hereditary disease, hereditary neoplastic syndrome, inherited neurodegenerative disorder, neoplasm, nervous system disorder, neurocutaneous syndrome, neurodegenerative disease, tuberous sclerosis, visual epilepsyActive, not recruitingNot stated2026-06-03NCT05485831
Pallidothalamic Tracts Electrical Stimulation for Lennox-Gastaut SyndromeCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorderActive, not recruitingNot applicable2026-04-13NCT06464653
The Children's Adaptive Deep Brain Stimulation for Epilepsy TrialCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorderRecruitingNot applicable2026-04-07NCT06924086
BMB-101 in Absence Epilepsy and DEECongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epilepsies, Myoclonic, Epilepsy, Absence, Epilepsy, Generalized, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, epilepsy with eyelid myoclonia, hereditary disease, nervous system disorderRecruitingPhase 22025-08-12NCT06401538
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and AdultsCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epileptic Syndromes, Lennox-Gastaut syndrome, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorder, visual epilepsyRecruitingPhase 32025-07-24NCT05219617
CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut SyndromeCongenital, Hereditary, and Neonatal Diseases and Abnormalities, Epilepsies, Myoclonic, Epilepsy, Generalized, Epileptic Syndromes, Lennox-Gastaut syndrome, brain disorder, central nervous system disorder, epilepsy, hereditary disease, nervous system disorderNot yet recruitingPhase 1 / Phase 22024-12-18NCT06738732