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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
BCMA/CD3 BsAb Therapy for POEMS SyndromeAbnormalities, Multiple, Blood Protein Disorders, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, POEMS syndrome, hematologic disorder, immune system disorder, immunoproliferative disorder, monoclonal gammopathy, nervous system disorder, neuromuscular disease, peripheral nervous system disorder, polyneuropathyRecruitingPhase 22026-09-29NCT07115654
A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFHAbnormalities, Multiple, Blood Protein Disorders, Castleman disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Hypergammaglobulinemia, Neoplasms by Histologic Type, Nutritional and Metabolic Diseases, POEMS syndrome, Skin and Connective Tissue Diseases, amyloidosis, cardiovascular disorder, cryoglobulinemia, heavy chain deposition disease, hematologic disorder, hemorrhagic disease, immune system disorder, immunoproliferative disorder, leukemia, light chain deposition disease, lymphatic system disorder, lymphoproliferative syndrome, metabolic disease, monoclonal gammopathy, monoclonal gammopathy of uncertain significance, neoplasm, nervous system disorder, neuromuscular disease, peripheral nervous system disorder, plasma cell leukemia, plasma cell neoplasm, polyneuropathy, precancerous condition, proteostasis deficiencies, skin disorder, skin vascular disease, smoldering plasma cell myeloma, vascular disorder, vascular hemostatic diseaseRecruitingNot stated2026-09-16NCT05283993
Polyneuropathy, Impairments and Physical Activity - The PolyImPAct StudyAbnormalities, Multiple, Blood Protein Disorders, Charcot-Marie-Tooth disease, Chronic Disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Diabetes Complications, Disease Attributes, Hemic and Lymphatic Diseases, POEMS syndrome, Pathologic Processes, Pathological Conditions, Signs and Symptoms, autoimmune disease, autoimmune disorder of the nervous system, central nervous system malformation, chronic inflammatory demyelinating polyradiculoneuropathy, demyelinating disease, diabetes mellitus, diabetic neuropathy, diabetic polyneuropathy, endocrine system disorder, hematologic disorder, hereditary disease, hereditary motor and sensory neuropathy, immune system disorder, immunoproliferative disorder, inherited neurodegenerative disorder, monoclonal gammopathy, multifocal motor neuropathy, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, polyradiculoneuropathy, vasculitic neuropathyActive, not recruitingNot stated2026-09-15NCT06040567
KCD (Carfilzomib/Cyclophosphamide/Dexamethasone) Regimen for the Treatment of Newly Diagnosed POEMS SyndromeAbnormalities, Multiple, Blood Protein Disorders, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, POEMS syndrome, hematologic disorder, immune system disorder, immunoproliferative disorder, monoclonal gammopathy, nervous system disorder, neuromuscular disease, peripheral nervous system disorder, polyneuropathyRecruitingPhase 22026-06-17NCT07652879
One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMSAbnormalities, Multiple, Blood Protein Disorders, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Immunoglobulin Light-chain Amyloidosis, Neoplasms by Histologic Type, Nutritional and Metabolic Diseases, POEMS syndrome, amyloidosis, cardiovascular disorder, hematologic disorder, hemorrhagic disease, immune system disorder, immunoproliferative disorder, lymphoproliferative syndrome, metabolic disease, monoclonal gammopathy, neoplasm, nervous system disorder, neuromuscular disease, peripheral nervous system disorder, plasma cell neoplasm, polyneuropathy, proteostasis deficiencies, vascular disorder, vascular hemostatic diseaseRecruitingNot stated2026-05-06NCT07448935
Registry for Adults With Plasma Cell Disorders (PCD's)Abnormalities, Multiple, Blood Protein Disorders, Castleman disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Hypergammaglobulinemia, Neoplasms by Histologic Type, Nutritional and Metabolic Diseases, POEMS syndrome, Skin and Connective Tissue Diseases, amyloidosis, cardiovascular disorder, cryoglobulinemia, heavy chain deposition disease, hematologic disorder, hemorrhagic disease, immune system disorder, immunoproliferative disorder, leukemia, light chain deposition disease, lymphatic system disorder, lymphoproliferative syndrome, metabolic disease, monoclonal gammopathy, neoplasm, nervous system disorder, neuromuscular disease, peripheral nervous system disorder, plasma cell leukemia, plasma cell neoplasm, polyneuropathy, precancerous condition, proteostasis deficiencies, skin disorder, skin vascular disease, smoldering plasma cell myeloma, vascular disorder, vascular hemostatic diseaseRecruitingNot stated2025-11-20NCT03717844
Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Inflammatory Diseases of the Nervous SystemAbnormalities, Multiple, Blood Protein Disorders, CNS demyelinating autoimmune disease, Chronic Disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Hemic and Lymphatic Diseases, Neoplasms by Site, POEMS syndrome, Paraneoplastic Syndromes, Nervous System, Pathologic Processes, Pathological Conditions, Signs and Symptoms, acquired idiopathic inflammatory myopathy, acute transverse myelitis, autoimmune disease, autoimmune disorder of the nervous system, autoimmune encephalitis, chronic inflammatory demyelinating polyradiculoneuropathy, cranial nerve neuropathy, demyelinating disease, eye disorder, hematologic disorder, immune system disorder, immunoproliferative disorder, monoclonal gammopathy, multiple sclerosis, muscle tissue disorder, musculoskeletal system disorder, myasthenia gravis, myelin oligodendrocyte glycoprotein antibody-associated disease, myositis disease, neoplasm, nervous system disorder, neurodegenerative disease, neuromuscular disease, neuromuscular junction disease, neuromyelitis optica, optic nerve disorder, optic neuritis, paraneoplastic syndrome, peripheral nervous system disorder, polyneuropathy, polyradiculoneuropathyRecruitingEarly phase 12024-10-30NCT04561557
A Study of KQ-2003 CAR-T Cell Therapy for Patients With Relapsed or Refractory POEMS SyndromeAbnormalities, Multiple, Blood Protein Disorders, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, POEMS syndrome, hematologic disorder, immune system disorder, immunoproliferative disorder, monoclonal gammopathy, nervous system disorder, neuromuscular disease, peripheral nervous system disorder, polyneuropathyNot yet recruitingPhase 12024-07-24NCT06518876