hereditary spastic paraplegia
hereditary spastic paraplegia
Explore linked clinical trials. Standard reference: MONDO:001906425 results · Page 1 of 1
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Neurologic Manifestations, Spinocerebellar Ataxias, Spinocerebellar Degenerations, atactic disorder, non-human animal, brain disorder, central nervous system disorder, central nervous system malformation, cerebellar ataxia, cerebellar disorder, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, spinal cord disorder | Active, not recruiting | Not stated | 2026-09-24 | NCT07838883 | |
| Genetic and Physical Study of Childhood Nerve and Muscle Disorders | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Muscular Disorders, Atrophic, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, muscle tissue disorder, muscular dystrophy, musculoskeletal system disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Active, not recruiting | Not stated | 2026-09-09 | NCT01568658 | |
| TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Disease Progression, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Spinocerebellar Degenerations, brain disorder, central nervous system disorder, central nervous system malformation, cerebellar disorder, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, spastic ataxia, spinal cord disorder | Recruiting | Not stated | 2026-09-01 | NCT07798674 | |
| Enhancement of Quality of Work And Life | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Neurologic Manifestations, Nutritional and Metabolic Diseases, Parkinson disease, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, atactic disorder, non-human animal, basal ganglia disorder, brain disorder, central nervous system disorder, central nervous system malformation, cerebellar ataxia, cerebellar disorder, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inborn mitochondrial metabolism disorder, inherited neurodegenerative disorder, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, parkinsonian disorder, peripheral nervous system disorder, polyneuropathy, synucleinopathy | Active, not recruiting | Not applicable | 2026-08-14 | NCT06573866 | |
| Phenotype, Genotype and Biomarkers 2 | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, amyotrophic lateral sclerosis, brain disorder, central nervous system disorder, central nervous system malformation, cognitive disorder, dementia, frontotemporal dementia, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, lateral sclerosis, metabolic disease, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, progressive muscular atrophy, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, spinal muscular atrophy | Active, not recruiting | Not stated | 2026-06-15 | NCT04875416 | |
| Phenotype, Genotype & Biomarkers in ALS and Related Disorders | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, amyotrophic lateral sclerosis, brain disorder, central nervous system disorder, central nervous system malformation, cognitive disorder, dementia, frontotemporal dementia, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, lateral sclerosis, metabolic disease, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, progressive muscular atrophy, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, spinal muscular atrophy | Active, not recruiting | Not stated | 2026-06-15 | NCT02327845 | |
| 12-Week Strength and Functional Exercise Program for Hereditary Spastic Paraplegia Trial (HSPMOVE) | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Enrolling by invitation | Not applicable | 2026-05-01 | NCT07561359 | |
| Neuromodulation to Enhance Motor Function in HSP | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not applicable | 2026-04-22 | NCT07417943 | |
| STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2026-03-27 | NCT06572046 | |
| Spastic Paraplegia - Centers of Excellence Research Network | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Spastic Paraplegia Type 4, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, hereditary spastic paraplegia 4, hereditary spastic paraplegia 5A, inherited neurodegenerative disorder, lateral sclerosis, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2026-03-18 | NCT06553976 | |
| Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Muscle Hypertonia, Muscle Spasticity, Neurologic Manifestations, Neuromuscular Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, central nervous system disorder, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, hereditary spastic paraplegia 26, hereditary spastic paraplegia 3A, inherited neurodegenerative disorder, motor neuron disorder, movement disorder, muscle tissue disorder, musculoskeletal system disorder, nervous system disorder, neurodegenerative disease, neurodevelopmental disorder, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, psychiatric disorder | Recruiting | Not stated | 2026-03-18 | NCT05354622 | |
| Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, hereditary spastic paraplegia 11, hereditary spastic paraplegia 15, hereditary spastic paraplegia 3A, hereditary spastic paraplegia 4, hereditary spastic paraplegia 47, hereditary spastic paraplegia 50, hereditary spastic paraplegia 51, hereditary spastic paraplegia 52, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, palsy, paraplegia, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2026-03-18 | NCT04712812 | |
| Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Charcot-Marie-Tooth disease, Chronic Disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Infections, Lambert-Eaton myasthenic syndrome, Lysosomal Storage Diseases, Nervous System, Muscular Disorders, Atrophic, Neoplasms by Site, Neuroinflammatory Diseases, Nutritional and Metabolic Diseases, Paraneoplastic Syndromes, Nervous System, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Picornaviridae infectious disease, RNA Virus Infections, TDP-43 proteinopathy, amyotrophic lateral sclerosis, autoimmune disease, autoimmune disorder of the nervous system, autonomic nervous system disorder, brain disorder, central nervous system disorder, central nervous system infectious disorder, central nervous system malformation, centronuclear myopathy, chronic inflammatory demyelinating polyradiculoneuropathy, congenital structural myopathy, demyelinating disease, disorder of glycogen metabolism, enterovirus infectious disease, facioscapulohumeral muscular dystrophy, glycogen storage disease II, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, immune system disorder, inborn carbohydrate metabolic disorder, inborn errors of metabolism, inborn mitochondrial metabolism disorder, inborn mitochondrial myopathy, inclusion body myositis, inherited neurodegenerative disorder, lateral sclerosis, lysosomal storage disease, metabolic disease, motor neuron disorder, muscle tissue disorder, muscular dystrophy, musculoskeletal system disorder, myasthenia gravis, myelitis, myositis disease, nemaline myopathy, neoplasm, nervous system disorder, neurodegenerative disease, neuromuscular disease, neuromuscular junction disease, orthostatic intolerance, paraneoplastic syndrome, peripheral nervous system disorder, poliomyelitis, polyneuropathy, polyradiculoneuropathy, postpoliomyelitis syndrome, primary dysautonomia, progressive muscular atrophy, proteostasis deficiencies, spinal cord disorder, spinal muscular atrophy, viral infectious disease | Recruiting | Not applicable | 2026-03-17 | NCT07478172 | |
| The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children | Brain Damage, Chronic, Brain Injuries, Traumatic, Charcot-Marie-Tooth disease, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Craniocerebral Trauma, brain disorder, brain injury, cardiovascular disorder, central nervous system disorder, central nervous system malformation, cerebral palsy, cerebrovascular disorder, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, injury, nervous system disorder, nervous system injury, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, spinal cord disorder, spinal cord injury, stroke disorder, vascular disorder | Recruiting | Not applicable | 2026-03-12 | NCT07090057 | |
| Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology | Body Weight, Charcot-Marie-Tooth disease, Cognition Disorders, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Huntington disease, Lambert-Eaton myasthenic syndrome, Muscular Disorders, Atrophic, Neoplasms by Site, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Overweight, Paraneoplastic Syndromes, Nervous System, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Spinocerebellar Ataxias, Spinocerebellar Degenerations, atactic disorder, non-human animal, autoimmune disease, autoimmune disorder of the nervous system, basal ganglia disorder, brain disorder, central nervous system disorder, central nervous system malformation, cerebellar ataxia, cerebellar disorder, choreatic disease, cognitive disorder, cranial nerve neuropathy, dementia, eye disorder, facioscapulohumeral muscular dystrophy, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, immune system disorder, inherited neurodegenerative disorder, movement disorder, muscle tissue disorder, muscular dystrophy, musculoskeletal system disorder, myasthenia gravis, myotonic dystrophy, myotonic syndrome, neoplasm, nervous system disorder, neurodegenerative disease, neuromuscular disease, neuromuscular junction disease, nutritional disorder, obesity disorder, ophthalmoplegia, overnutrition, palsy, paraneoplastic syndrome, peripheral nervous system disorder, polyneuropathy, psychiatric disorder, spinal cord disorder, tauopathy | Recruiting | Not applicable | 2025-08-22 | NCT07136844 | |
| Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP) | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2025-05-04 | NCT06728787 | |
| Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Muscle Hypertonia, Muscle Spasticity, Neurologic Manifestations, Neuromuscular Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, central nervous system disorder, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, hereditary spastic paraplegia 47, hereditary spastic paraplegia 50, hereditary spastic paraplegia 51, hereditary spastic paraplegia 52, inherited neurodegenerative disorder, movement disorder, muscle tissue disorder, musculoskeletal system disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Not yet recruiting | Phase 1 / Phase 2 | 2025-04-28 | NCT06948019 | |
| A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Foot Deformities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, musculoskeletal system disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2025-04-20 | NCT06936163 | |
| Natural History Study of Patients with HPDL Mutations | Brain Diseases, Metabolic, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Leukoencephalopathies, Neurologic Manifestations, Nutritional and Metabolic Diseases, Paraplegia, Spastic, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inborn mitochondrial metabolism disorder, inborn mitochondrial myopathy, inherited neurodegenerative disorder, metabolic disease, mitochondrial encephalomyopathy, muscle tissue disorder, musculoskeletal system disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, palsy, paraplegia, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2025-03-30 | NCT05848271 | |
| A Prospective Cohort Study of ITB Treatment for HSP | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2025-02-26 | NCT06844734 | |
| Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not applicable | 2025-01-30 | NCT06742697 | |
| Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not applicable | 2024-11-25 | NCT06229626 | |
| Calcium Folinate Treatment of Spastic Paraplegia 56 | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Early phase 1 | 2024-06-27 | NCT06478238 | |
| The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4 | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Autosomal Dominant Spastic Paraplegia, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not applicable | 2022-08-23 | NCT03206190 | |
| Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, hereditary disease, hereditary motor and sensory neuropathy, hereditary spastic paraplegia, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy | Recruiting | Not stated | 2021-05-19 | NCT03981276 |