primary progressive aphasia
primary progressive aphasia
Explore linked clinical trials. Standard reference: MONDO:001980638 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia | primary progressive aphasia | Not yet recruiting | Not applicable | 2026-10-01 | NCT07511179 | |
| Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA | Nerve Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, logopenic progressive aphasia, nervous system disorder, primary progressive aphasia, psychiatric disorder, speech disorder | Recruiting | Not applicable | 2026-09-09 | NCT03887481 | |
| Remotely-supervised Neuromodulation in PPA | Aphasia, Progressive, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, nervous system disorder, neurodevelopmental disorder, primary progressive aphasia, psychiatric disorder, speech disorder | Recruiting | Not applicable | 2026-09-04 | NCT07260253 | |
| Biofluid Research on Age-Related or Inherited Neurodegeneration | Alzheimer disease, Lewy body dementia, Nerve Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Parkinson disease, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, aphasia, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, cranial nerve neuropathy, dementia, eye disorder, language disorder, limbic-predominant age-related TDP-43 encephalopathy, metabolic disease, motor neuron disorder, movement disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, parkinsonian disorder, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder, spinal cord disorder, synucleinopathy, tauopathy | Recruiting | Not stated | 2026-09-01 | NCT07798700 | |
| A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Recruiting | Phase 1 / Phase 2 | 2026-08-13 | NCT06064890 | |
| Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Pick disease, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, nervous system disorder, neurodevelopmental disorder, nominal aphasia, primary progressive aphasia, psychiatric disorder, speech disorder | Recruiting | Not applicable | 2026-08-11 | NCT04957537 | |
| Propranolol in Primary Progressive Aphasia | Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, nervous system disorder, primary progressive aphasia, psychiatric disorder, speech disorder | Recruiting | Early phase 1 | 2026-07-17 | NCT06066710 | |
| Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Active, not recruiting | Phase 2 | 2026-07-06 | NCT07033481 | |
| Stimulating the Aging Brain Using Brain and Sensory Stimulation | Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, nervous system disorder, primary progressive aphasia, psychiatric disorder, speech disorder | Recruiting | Not applicable | 2026-06-16 | NCT07650188 | |
| Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia | Alzheimer disease, Aphasia, Progressive, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, nervous system disorder, neurodegenerative disease, primary progressive aphasia, psychiatric disorder, speech disorder, tauopathy | Recruiting | Early phase 1 | 2026-06-10 | NCT06511752 | |
| Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia | Alzheimer disease, Apraxia, Motor, Dysarthria, Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Psychomotor Disorders, Signs and Symptoms, TDP-43 proteinopathy, aphasia, apraxia, articulation disorder, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, neurodevelopmental disorder, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder, tauopathy | Recruiting | Not applicable | 2026-06-10 | NCT05741853 | |
| Communication Bridge 3 Study | Alzheimer disease, Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder, tauopathy | Recruiting | Phase 2 | 2026-06-01 | NCT06191198 | |
| Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia | Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, nervous system disorder, primary progressive aphasia, psychiatric disorder, speech disorder | Enrolling by invitation | Not applicable | 2026-05-20 | NCT06921265 | |
| Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation | Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Psychomotor Disorders, Signs and Symptoms, aphasia, apraxia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, nervous system disorder, primary progressive aphasia, psychiatric disorder, speech disorder | Active, not recruiting | Not applicable | 2026-05-08 | NCT05368350 | |
| Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases | Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, aphasia, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, cranial nerve neuropathy, dementia, eye disorder, language disorder, metabolic disease, motor neuron disorder, movement disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder, spinal cord disorder, tauopathy | Enrolling by invitation | Not applicable | 2026-05-05 | NCT07567664 | |
| Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, logopenic progressive aphasia, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, progressive non-fluent aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Recruiting | Phase 2 | 2026-05-05 | NCT05386394 | |
| The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech | Aphasia, Broca, Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Psychomotor Disorders, Signs and Symptoms, TDP-43 proteinopathy, aphasia, apraxia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, progressive non-fluent aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Recruiting | Not stated | 2026-05-01 | NCT03313011 | |
| Long Term Effect of Brain Stimulation in PPA | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Recruiting | Not applicable | 2026-04-23 | NCT07158216 | |
| Intervention for Communication Quality of Life in Primary Progressive Aphasia | Aphasia, Progressive, Aphasia, Semantic, Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, logopenic progressive aphasia, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, progressive non-fluent aphasia, proteostasis deficiencies, psychiatric disorder, semantic dementia, speech disorder | Recruiting | Not applicable | 2026-04-21 | NCT07219680 | |
| The Swedish BioFINDER 2 Study | Alzheimer disease, Cognition Disorders, Cognitive Dysfunction, Frontotemporal Lobar Degeneration, Lewy body dementia, Mild Cognitive Impairment, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Parkinson disease, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Pick disease, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, aphasia, autonomic nervous system disorder, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, disease, eye disorder, frontotemporal dementia, language disorder, metabolic disease, motor neuron disorder, movement disorder, multiple system atrophy, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, parkinsonian disorder, primary dysautonomia, primary progressive aphasia, progressive non-fluent aphasia, progressive supranuclear palsy, progressive supranuclear palsy-parkinsonism syndrome, proteostasis deficiencies, psychiatric disorder, semantic dementia, speech disorder, spinal cord disorder, synucleinopathy, tauopathy | Recruiting | Not applicable | 2026-04-06 | NCT03174938 | |
| Language in Primary Progressive Aphasia | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, progressive non-fluent aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Recruiting | Not stated | 2026-02-27 | NCT00537004 | |
| Speech and Language Interventions for Italian People With PPA | Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, aphasia, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, language disorder, metabolic disease, nervous system disorder, neurodegenerative disease, neurodevelopmental disorder, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder | Recruiting | Not stated | 2026-02-20 | NCT06739967 | |
| UPenn Observational Research Repository on Neurodegenerative Disease | Alzheimer disease, Lewy body dementia, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, aphasia, basal ganglia disorder, brain disorder, central nervous system disorder, cognitive disorder, communication disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, eye disorder, language disorder, metabolic disease, motor neuron disorder, movement disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, parkinsonian disorder, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, speech disorder, spinal cord disorder, synucleinopathy, tauopathy | Recruiting | Not stated | 2026-01-22 | NCT04715399 | |
| Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration | Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, metabolic disease, nervous system disorder, neurodegenerative disease, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, supranuclear palsy, progressive, 1 | Recruiting | Not applicable | 2026-01-05 | NCT07316413 | |
| Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders | Aphasia, Semantic, Frontotemporal Lobar Degeneration, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Parkinson disease, Pathological Conditions, Signs and Symptoms, Pick disease, Psychomotor Disorders, Signs and Symptoms, TDP-43 proteinopathy, aphasia, apraxia, autonomic nervous system disorder, basal ganglia disorder, behavioral variant of frontotemporal dementia, brain disorder, cardiovascular disorder, central nervous system disorder, cognitive disorder, communication disorder, dementia, frontotemporal dementia, hypotensive disorder, language disorder, logopenic progressive aphasia, metabolic disease, movement disorder, multiple system atrophy, nervous system disorder, neurodegenerative disease, parkinsonian disorder, posterior cortical atrophy, primary dysautonomia, primary progressive aphasia, proteostasis deficiencies, psychiatric disorder, semantic dementia, speech disorder, supranuclear palsy, progressive, 1, synucleinopathy, vascular disorder | Enrolling by invitation | Not stated | 2025-11-21 | NCT04680130 |