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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
B7-H3.CD28Z.CART in CNS NeoplasmsBrain Tumor, Recurrent, Medulloblastoma, Adult, Medulloblastoma, Childhood, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, atypical teratoid rhabdoid tumor, brain disorder, central nervous system cancer, central nervous system disorder, embryonal tumor with multilayered rosettes, ependymoma, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, rhabdoid tumor, tumor of meningesRecruitingPhase 12026-09-03NCT07390539
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and SarcomasEwing sarcoma, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, Neuroectodermal Tumors, Primitive, Peripheral, atypical teratoid rhabdoid tumor, brain disorder, brainstem cancer, central nervous system cancer, central nervous system disorder, connective tissue neoplasm, diffuse intrinsic pontine glioma, embryonal tumor with multilayered rosettes, epithelial neoplasm, glioma, mixed neoplasm, neoplasm, nervous system disorder, neuroblastoma, neuroepithelial neoplasm, osteosarcoma, primitive neuroectodermal tumor, rhabdoid tumor, sarcomaRecruitingPhase 1 / Phase 22026-09-03NCT06465199
Phase 2 Study of Alisertib Therapy for Rhabdoid TumorsNeoplasms by Histologic Type, atypical teratoid rhabdoid tumor, mixed neoplasm, neoplasm, rhabdoid tumorActive, not recruitingPhase 22026-09-01NCT02114229
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post ConsolidationDigestive System Diseases, Medulloblastoma, Childhood, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, Neuroectodermal Tumors, Primitive, Peripheral, atypical teratoid rhabdoid tumor, brain disorder, central nervous system cancer, central nervous system disorder, digestive system disorder, embryonal tumor with multilayered rosettes, ependymoblastoma, epithelial neoplasm, glioma, hypertrophic pyloric stenosis, medulloblastoma, medulloepithelioma, mixed neoplasm, neoplasm, nervous system disorder, neuroblastoma, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, pyloric stenosis, rhabdoid tumor, stomach disorderRecruitingEarly phase 12026-07-14NCT06942039
Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient TumorsNeoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Germ Cell and Embryonal, atypical teratoid rhabdoid tumor, chordoma, kidney medullary carcinoma, mixed neoplasm, neoplasm, poorly differentiated chordoma, rhabdoid tumor, sarcomaActive, not recruitingPhase 1 / Phase 22026-07-14NCT05286801
Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS TumorsNeoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, astrocytoma (excluding glioblastoma), atypical teratoid rhabdoid tumor, central nervous system cancer, diffuse midline glioma, H3 K27M-mutant, ependymoma, epithelial neoplasm, glioblastoma, glioma, malignant glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, primitive neuroectodermal tumor, rhabdoid tumorActive, not recruitingPhase 12026-07-06NCT05835687
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative CancersNeoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Germ Cell and Embryonal, atypical teratoid rhabdoid tumor, chordoma, mixed neoplasm, neoplasm, rhabdoid tumor, rhabdoid tumor of the kidney, sarcomaActive, not recruitingPhase 22026-07-01NCT04416568
Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def TumorsNeoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Germ Cell and Embryonal, atypical teratoid rhabdoid tumor, chordoma, mixed neoplasm, neoplasm, rhabdoid tumor, rhabdoid tumor of the kidney, sarcomaActive, not recruitingPhase 1 / Phase 22026-04-13NCT05407441
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System TumorsMedulloblastoma, Childhood, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, atypical teratoid rhabdoid tumor, brain disorder, brainstem cancer, central nervous system cancer, central nervous system disorder, choroid plexus carcinoma, diffuse intrinsic pontine glioma, ependymoma, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, primitive neuroectodermal tumor, rhabdoid tumorRecruitingPhase 12026-04-13NCT04185038
GPC3 CAR T Cells With IL-15 and IL-21 for Recurrent ATRT and CNS Rhabdoid Tumors (RADIANT)Neoplasms by Histologic Type, Simpson-Golabi-Behmel syndrome, atypical teratoid rhabdoid tumor, mixed neoplasm, neoplasm, rhabdoid tumorNot yet recruitingPhase 12026-04-07NCT07513194
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS TumorsNeoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, atypical teratoid rhabdoid tumor, brain disorder, central nervous system cancer, central nervous system disorder, choroid plexus carcinoma, ependymoma, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, rhabdoid tumorActive, not recruitingPhase 12025-12-17NCT03500991