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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young AdultsNeoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, brain disorder, central nervous system cancer, central nervous system disorder, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, rhabdoid tumorRecruitingPhase 12026-10-09NCT07087002
A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain TumorsNeoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, brain disorder, central nervous system cancer, central nervous system disorder, childhood brain stem neoplasm, choroid plexus carcinoma, diffuse midline glioma, H3 K27M-mutant, epithelial neoplasm, glioma, malignant glioma, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineocytoma, primitive neuroectodermal tumor, spinal cord disorder, spinal cord neoplasmRecruitingPhase 12026-09-15NCT06357377
B7-H3.CD28Z.CART in CNS NeoplasmsBrain Tumor, Recurrent, Medulloblastoma, Adult, Medulloblastoma, Childhood, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, atypical teratoid rhabdoid tumor, brain disorder, central nervous system cancer, central nervous system disorder, embryonal tumor with multilayered rosettes, ependymoma, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, rhabdoid tumor, tumor of meningesRecruitingPhase 12026-09-03NCT07390539
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post ConsolidationDigestive System Diseases, Medulloblastoma, Childhood, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, Neuroectodermal Tumors, Primitive, Peripheral, atypical teratoid rhabdoid tumor, brain disorder, central nervous system cancer, central nervous system disorder, digestive system disorder, embryonal tumor with multilayered rosettes, ependymoblastoma, epithelial neoplasm, glioma, hypertrophic pyloric stenosis, medulloblastoma, medulloepithelioma, mixed neoplasm, neoplasm, nervous system disorder, neuroblastoma, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, pyloric stenosis, rhabdoid tumor, stomach disorderRecruitingEarly phase 12026-07-14NCT06942039
Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)Medulloblastoma, Childhood, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, brain disorder, central nervous system cancer, central nervous system disorder, embryonal tumor with multilayered rosettes, ependymoma, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, rhabdoid tumorRecruitingPhase 12026-06-17NCT06193759
A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies.Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, brain disorder, central nervous system cancer, central nervous system disorder, epithelial neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumorRecruitingEarly phase 12026-04-29NCT07017816
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System TumorsMedulloblastoma, Childhood, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, atypical teratoid rhabdoid tumor, brain disorder, brainstem cancer, central nervous system cancer, central nervous system disorder, choroid plexus carcinoma, diffuse intrinsic pontine glioma, ependymoma, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, primitive neuroectodermal tumor, rhabdoid tumorRecruitingPhase 12026-04-13NCT04185038
Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS TumorsEwing sarcoma, Hemic and Lymphatic Diseases, Histiocytosis, Langerhans-Cell, Myosarcoma, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Bone Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, Neuroectodermal Tumors, Primitive, Peripheral, brain disorder, cancer, carcinoma, central nervous system cancer, central nervous system disorder, connective tissue neoplasm, ependymoma, epithelial neoplasm, glioma, histiocytosis, interstitial lung disease, lung disorder, lymphatic system disorder, medulloblastoma, mixed neoplasm, myomatous neoplasm, neoplasm, nervous system disorder, neuroblastoma, neuroepithelial neoplasm, osteosarcoma, pineal body neoplasm, primitive neuroectodermal tumor, respiratory system disorder, rhabdoid tumor, rhabdomyosarcoma, sarcomaActive, not recruitingPhase 22026-03-02NCT02574728
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System NeoplasmsChoroid Plexus Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, Teratoid Rhabdoid Tumor, Typical Teratoid Rhabdoid Tumor, anaplastic astrocytoma, anaplastic ependymoma, anaplastic meningioma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma, astrocytoma (excluding glioblastoma), brain disorder, central nervous system cancer, central nervous system disorder, cerebral ventricle cancer, diffuse astrocytoma, diffuse midline glioma, H3 K27M-mutant, ependymoma, epithelial neoplasm, glioblastoma, glioma, gliomatosis cerebri, gliosarcoma, medulloblastoma, meningioma, neoplasm, nervous system disorder, neuroepithelial neoplasm, oligodendroglioma, pilocytic astrocytoma, pineal body neoplasm, primitive neuroectodermal tumor, tumor of meninges, vascular cancerRecruitingPhase 12025-12-18NCT04541082
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO ClassificationChoroid Plexus Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, brain disorder, capillary hemangioma, central nervous system cancer, central nervous system disorder, central nervous system melanocytic neoplasm, cerebral ventricle cancer, diffuse midline glioma, H3 K27M-mutant, embryonal neoplasm, ependymoma, epithelial neoplasm, glioma, hemangioblastoma, hemangioma, hemangiopericytoma, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, primitive neuroectodermal tumor, vascular cancerRecruitingNot stated2025-12-17NCT05259605
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS TumorsNeoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, atypical teratoid rhabdoid tumor, brain disorder, central nervous system cancer, central nervous system disorder, choroid plexus carcinoma, ependymoma, epithelial neoplasm, glioma, medulloblastoma, mixed neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, pineoblastoma, primitive neuroectodermal tumor, rhabdoid tumorActive, not recruitingPhase 12025-12-17NCT03500991
International HIT-MED Registry (I-HIT-MED)Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, brain disorder, central nervous system cancer, central nervous system disorder, ependymoma, epithelial neoplasm, glioma, medulloblastoma, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, primitive neuroectodermal tumorRecruitingNot stated2025-12-04NCT02417324
International PPB/DICER1 RegistryAdnexal Diseases, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, DICER1-related tumor predisposition, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Gynandroblastoma, Head and Neck Neoplasms, Male Urogenital Diseases, Myosarcoma, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Connective and Soft Tissue, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neuroectodermal Tumors, Primitive, Neuroectodermal Tumors, Primitive, Peripheral, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Pituitary Neoplasms, Rhabdomyosarcoma, Embryonal, Sertoli-Leydig cell tumor, Sex Cord-Gonadal Stromal Tumors, Thyroid Nodule, Urogenital Diseases, Urogenital Neoplasms, Wilms tumor, benign cystic nephroma, benign urinary system neoplasm, brain disorder, central nervous system cancer, central nervous system disorder, disease, endocrine system disorder, epithelial neoplasm, female reproductive system disorder, female reproductive system neoplasm, goiter, gonadal disorder, gonadal tissue neoplasm, hereditary disease, hereditary neoplastic syndrome, hypothalamic disorder, hypothalamic neoplasm, kidney cancer, kidney disorder, kidney sarcoma, male reproductive organ cancer, male reproductive system disorder, malignant endocrine neoplasm, mixed neoplasm, myomatous neoplasm, neoplasm, nervous system disorder, neuroblastoma, neuroepithelial neoplasm, nodular goiter, ovarian cancer, ovarian disorder, ovarian sarcoma, pineal body neoplasm, pineoblastoma, pituitary gland disorder, pleuropulmonary blastoma, primitive neuroectodermal tumor, rhabdomyosarcoma, sarcoma, supratentorial cancer, testicular cancer, testicular disorder, thyroid gland carcinoma, thyroid gland disorder, thyroid tumor, urinary system disorderRecruitingNot stated2025-01-30NCT03382158
The Evolution of Neuroendoscopy Guided by Head-mounted Mixed Reality Technique Navigation System in NeurosurgeryNeoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, brain disorder, brainstem cancer, central nervous system cancer, central nervous system disorder, epithelial neoplasm, neoplasm, nervous system disorder, neuroepithelial neoplasm, pineal body neoplasm, primitive neuroectodermal tumorNot yet recruitingNot applicable2024-07-24NCT06516471