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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster HeadacheHeadache, Neurologic Manifestations, Pain, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaNot yet recruitingPhase 22026-10-02NCT07714369
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEADBronchiolitis Obliterans, brain disorder, bronchial disorder, bronchiolitis, bronchiolitis obliterans syndrome, bronchitis, central nervous system disorder, cluster headache syndrome, cryptogenic organizing pneumonia, graft versus host disease, headache disorder, hypnic headache, immune system disorder, lung disorder, migraine disorder, nervous system disorder, obstructive lung disease, respiratory system disorder, trigeminal autonomic cephalalgiaRecruitingNot applicable2026-09-23NCT07348783
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot StudyBronchiolitis Obliterans, brain disorder, bronchial disorder, bronchiolitis, bronchiolitis obliterans syndrome, bronchitis, central nervous system disorder, cluster headache syndrome, cryptogenic organizing pneumonia, graft versus host disease, headache disorder, hypnic headache, immune system disorder, lung disorder, migraine disorder, nervous system disorder, obstructive lung disease, respiratory system disorder, trigeminal autonomic cephalalgiaActive, not recruitingNot applicable2026-09-23NCT07292090
Italian Trigeminal Autonomic Cephalalgias Assessment Studybrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hemicrania continua, hypnic headache, nervous system disorder, paroxysmal Hemicrania, trigeminal autonomic cephalalgiaRecruitingNot stated2026-09-22NCT07812740
A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant MigraineHeadache, Neurologic Manifestations, Pain, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, migraine disorder, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingNot applicable2026-08-28NCT07719608
A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingNot applicable2026-08-27NCT07677137
Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacksbrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaNot yet recruitingPhase 22026-08-25NCT06950281
High- vs Standard-Dose Intravenous Magnesium for Acute HeadacheAcute Pain, Disease Attributes, Emergencies, Neurobehavioral Manifestations, Neurologic Manifestations, Pain, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Tension-Type Headache, agnosia, brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, migraine disorder, nervous system disorder, perceptual disorders, trigeminal autonomic cephalalgiaRecruitingNot applicable2026-08-21NCT07779486
Response to Combined Trigeminal and Occipital Nerve Stimulation for the Preventive Treatment in Chronic Cluster Headachebrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingNot applicable2026-07-16NCT07113470
Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial PainCraniofacial Pain, Facial Pain, Neurologic Manifestations, Pain, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Stomatognathic Diseases, brain disorder, central nervous system disorder, cluster headache syndrome, cranial nerve neuropathy, facial nerve disorder, facial neuralgia, headache disorder, hypnic headache, migraine disorder, mouth disorder, nervous system disorder, paroxysmal Hemicrania, trigeminal autonomic cephalalgiaRecruitingPhase 22026-04-27NCT04930887
REsponse to Combined SONS and ONS in Chronic Cluster headachEbrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaActive, not recruitingNot applicable2026-04-23NCT05868044
Pain Biomarker StudyLacerations, brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hemicrania continua, hypnic headache, injury, migraine disorder, nervous system disorder, paroxysmal Hemicrania, trigeminal autonomic cephalalgiaEnrolling by invitationPhase 12026-02-18NCT03511846
The Will Erwin Headache Research Center - Cluster Headache StudyStomatognathic Diseases, brain disorder, central nervous system disorder, cluster headache syndrome, cranial nerve neuropathy, facial nerve disorder, facial neuralgia, headache disorder, hemicrania continua, hypnic headache, mouth disorder, nervous system disorder, paroxysmal Hemicrania, trigeminal autonomic cephalalgia, trigeminal nerve disorder, trigeminal neuralgiaRecruitingNot stated2026-02-18NCT02910323
Atrioventricular Block and Cluster Headache (SEVA)brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaActive, not recruitingPhase 42025-12-02NCT04406259
Repeated GON Injections in CCHbrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingPhase 32025-11-24NCT05324748
nVNS for the Prevention and Treatment of Primary HeadacheTension-Type Headache, brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingNot applicable2025-08-12NCT06277063
China Headache and Vertigo Registry StudyEar Diseases, Headache Disorders, Secondary, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Tension-Type Headache, Vertigo, Vertigo, Constant, Vestibular Migraine, brain disorder, central nervous system disorder, cluster headache syndrome, fibromyalgia, headache disorder, hypnic headache, inner ear disorder, migraine disorder, muscle tissue disorder, musculoskeletal system disorder, nervous system disorder, neuromuscular disease, otorhinolaryngologic disease, rheumatic disorder, trigeminal autonomic cephalalgia, vestibular disorderRecruitingNot stated2025-07-25NCT04939922
LSD to Improve Cluster Headache Impact Trialbrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingPhase 22025-04-15NCT05477459
Pulsed Radiofrequency Combined With Platelet-Rich Plasma Applied to the Sphenopalatine Ganglion in Treating Episodic Cluster HeadacheEpisodic Cluster Headache, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, agnosia, brain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, perceptual disorders, trigeminal autonomic cephalalgiaNot yet recruitingNot stated2025-03-24NCT06882278
Efficacy of Light Therapy in Treatment of Chronic Cluster Headachebrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingNot applicable2025-03-17NCT06540651
Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headachebrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingPhase 22025-02-07NCT03781128
SPG Pulsed Radiofrequency for Chronic Cluster Headachebrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingNot applicable2025-01-27NCT06787677
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headachebrain disorder, central nervous system disorder, cluster headache syndrome, headache disorder, hypnic headache, nervous system disorder, trigeminal autonomic cephalalgiaRecruitingPhase 32024-11-19NCT03944876
Quest to Analyze One Thousand Humans MeditatingAdnexal Diseases, Angina Pectoris, Angina, Stable, Arrhythmias, Cardiac, Bacterial Infections and Mycoses, Bone Diseases, Metabolic, Borrelia infectious disease, Brain Damage, Chronic, CNS demyelinating autoimmune disease, Chest Pain, Chronic Disease, Chronic Kidney Diseases, Crohn disease, Cysts, Deafness, Digestive System Diseases, Digestive System Neoplasms, Disease Attributes, Ear Diseases, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Head and Neck Neoplasms, Hemic and Lymphatic Diseases, Hypersensitivity, Immediate, Infections, Lyme disease, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Connective and Soft Tissue, Neurobehavioral Manifestations, Neuroinflammatory Diseases, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pain, Parkinson disease, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Phantom Limb, Phantom Limb Pain, Postoperative Complications, Postoperative Pain, Respiratory Hypersensitivity, Sensation Disorders, Signs and Symptoms, Skin Diseases, Eczematous, Skin Diseases, Papulosquamous, Skin and Connective Tissue Diseases, Stress Disorders, Traumatic, TDP-43 proteinopathy, Tension-Type Headache, Thoracic Neoplasms, Urogenital Diseases, Urogenital Neoplasms, acute stress disorder, amyotrophic lateral sclerosis, anxiety, anxiety disorder, arthritic joint disease, arthropathy, asthma, atopic eczema, atrial fibrillation, autoimmune disease, autoimmune disorder of the nervous system, bacterial infectious disease, basal ganglia disorder, bone disorder, brain disorder, breast cancer, breast disorder, breast neoplasm, bronchial disorder, cardiovascular disorder, central nervous system cancer, central nervous system disorder, cerebral palsy, cerebrovascular disorder, chronic obstructive pulmonary disease, chronic renal failure syndrome, cluster headache syndrome, colitis, colonic disorder, colonic neoplasm, colorectal neoplasm, connective tissue disorder, demyelinating disease, depressive disorder, dermatitis, diabetes mellitus, digestive system disorder, digestive system neoplasm, encephalomyelitis, endocrine system disorder, epilepsy, eye disorder, female reproductive system disorder, female reproductive system neoplasm, fibromyalgia, functional colonic disease, gastroenteritis, glucose metabolism disease, gonadal disorder, gram-negative bacterial infections, headache disorder, hearing disorder, hearing loss disorder, heart disorder, heart failure, hypertensive disorder, hyperthyroidism, hypnic headache, hypothyroidism, immune system disorder, immunoproliferative disorder, infertility disorder, inflammatory bowel disease, injury, intestinal disorder, irritable bowel syndrome, kidney disorder, kidney failure, leiomyoma, lung cancer, lung disorder, lung neoplasm, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, macular degeneration, male reproductive organ cancer, male reproductive system disorder, malignant endocrine neoplasm, metabolic disease, migraine disorder, motor neuron disorder, movement disorder, multiple sclerosis, muscle tissue disorder, musculoskeletal system disorder, myalgic encephalomeyelitis/chronic fatigue syndrome, myocardial ischemia, myomatous neoplasm, neoplasm, nervous system disorder, nervous system injury, neurodegenerative disease, neuromuscular disease, obstructive lung disease, osteoarthritis, osteoporosis, otorhinolaryngologic disease, ovarian cancer, ovarian cyst, ovarian disorder, parkinsonian disorder, perceptual disorders, post-traumatic stress disorder, prostate cancer, prostate disorder, proteostasis deficiencies, psoriasis, psychiatric disorder, respiratory system disorder, respiratory tract neoplasm, retinal degeneration, retinal disorder, rheumatic disorder, rheumatoid arthritis, skin disorder, skin neoplasm, spinal cord disorder, spinal cord injury, spinal stenosis, spirochaetales infections, stroke disorder, synucleinopathy, thyroid gland carcinoma, thyroid gland disorder, thyroid tumor, tick-borne infectious disease, tinnitus, trigeminal autonomic cephalalgia, ulcerative colitis, urinary system disorder, vascular disorder, vector-borne disease, vertebral column disorderEnrolling by invitationNot stated2024-11-01NCT06583395