neoplastic meningitis
neoplastic meningitis
Explore linked clinical trials. Standard reference: MONDO:070021960 results ยท Page 1 of 3
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Active, not recruiting | Phase 1 / Phase 2 | 2026-09-24 | NCT06462222 | |
| Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Not yet recruiting | Phase 2 | 2026-09-22 | NCT07833657 | |
| Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases | Neoplasm Metastasis, Neoplasms by Site, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Recruiting | Phase 1 / Phase 2 | 2026-09-09 | NCT07098806 | |
| Wearable-Triggered Digital Safety Net for Real-Time Monitoring & Intervention in Leptomeningeal Metastasis | Neoplasms by Site, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Not yet recruiting | Not applicable | 2026-09-03 | NCT07704034 | |
| Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Active, not recruiting | Phase 1 / Phase 2 | 2026-09-02 | NCT06809530 | |
| Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Active, not recruiting | Phase 1 / Phase 2 | 2026-09-02 | NCT06762080 | |
| BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies | Neoplasms by Site, Skin and Connective Tissue Diseases, Thoracic Neoplasms, breast cancer, breast disorder, breast neoplasm, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, lung disorder, lung neoplasm, neoplasm, neoplastic meningitis, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasm, skin disorder, tumor of meninges | Not yet recruiting | Phase 2 | 2026-09-01 | NCT07789912 | |
| Thiotepa Administration Via Ommaya Reservoir for Leptomeningeal Metastases in Non-Small Cell Lung Cancer Resistant to EGFR-TKI. | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Not yet recruiting | Phase 2 | 2026-08-21 | NCT07778940 | |
| Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial | Neoplasms by Site, Skin and Connective Tissue Diseases, Thoracic Neoplasms, breast disorder, breast neoplasm, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, lung disorder, lung neoplasm, neoplasm, neoplastic meningitis, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasm, skin disorder, tumor of meninges | Recruiting | Phase 3 | 2026-08-17 | NCT06500481 | |
| Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer | Neoplasms by Site, Skin and Connective Tissue Diseases, Thoracic Neoplasms, breast disorder, breast neoplasm, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, lung disorder, lung neoplasm, neoplasm, neoplastic meningitis, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasm, skin disorder, tumor of meninges | Recruiting | Phase 2 | 2026-08-14 | NCT06518057 | |
| Dual-targeting VEGFR1 and PD-L1 CAR-T for Pleural, Peritoneal, or Leptomeningeal Metastases | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Recruiting | Phase 1 | 2026-08-13 | NCT05477927 | |
| HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases | Neoplasms by Site, Skin and Connective Tissue Diseases, brain disorder, breast cancer, breast disorder, breast neoplasm, cancer, central nervous system cancer, central nervous system disorder, metastatic malignant neoplasm in the brain, neoplasm, neoplastic meningitis, nervous system disorder, skin disorder, tumor of meninges | Active, not recruiting | Phase 1 | 2026-08-12 | NCT03696030 | |
| Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers | Digestive System Diseases, Digestive System Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, brain disorder, carcinoma, central nervous system cancer, central nervous system disorder, digestive system disorder, digestive system neoplasm, epithelial neoplasm, esophageal adenocarcinoma, esophageal disorder, esophageal squamous cell carcinoma, gastric cardia adenocarcinoma, metastatic malignant neoplasm in the brain, neoplasm, neoplastic meningitis, nervous system disorder, squamous cell carcinoma, squamous cell neoplasm, tumor of meninges | Active, not recruiting | Phase 1 | 2026-07-31 | NCT04460937 | |
| Safety and Efficacy of Intrathecal Sacituzumab Tirumotecan for Leptomeningeal Metastasis in EGFR-TKI-Resistant Non-Small Cell Lung Cancer | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Not yet recruiting | Phase 1 | 2026-07-14 | NCT07702305 | |
| A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis | Disease Attributes, Neoplasms by Site, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Recurrence, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Recruiting | Phase 1 | 2026-07-14 | NCT05184816 | |
| Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal Metastases | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Not yet recruiting | Phase 1 | 2026-06-29 | NCT07674693 | |
| Zorifertinib With Osimertinib for NSCLC With Meningeal Progression | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Recruiting | Phase 1 | 2026-06-22 | NCT07361705 | |
| QH101 Cell Injection in Patients With Brain, Brain (Spinal) Meninges, and Spinal Cord Metastatic Malignant Solid Tumors | Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Not yet recruiting | Early phase 1 | 2026-06-18 | NCT07656103 | |
| Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Active, not recruiting | Phase 1 / Phase 2 | 2026-05-26 | NCT04588545 | |
| Concurrent Azeliragon With Craniospinal Irradiation | Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, central nervous system cancer, epithelial neoplasm, glioma, malignant glioma, neoplasm, neoplastic meningitis, nervous system disorder, neuroepithelial neoplasm, primitive neuroectodermal tumor, tumor of meninges | Active, not recruiting | Phase 1 | 2026-05-18 | NCT06724926 | |
| Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer | Neoplasms by Site, central nervous system cancer, neoplasm, neoplastic meningitis, nervous system disorder, non-small cell lung carcinoma, tumor of meninges | Recruiting | Phase 1 | 2026-05-08 | NCT06431685 | |
| Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI | Neoplasms by Site, Thoracic Neoplasms, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, lung disorder, lung neoplasm, neoplasm, neoplastic meningitis, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasm, tumor of meninges | Not yet recruiting | Phase 2 | 2026-04-24 | NCT07551414 | |
| Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study | Neoplasms by Site, Thoracic Neoplasms, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, lung disorder, lung neoplasm, neoplasm, neoplastic meningitis, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasm, tumor of meninges | Recruiting | Not applicable | 2026-04-23 | NCT07398599 | |
| GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases | Brain Metastases, Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, neoplastic meningitis, nervous system disorder, tumor of meninges | Active, not recruiting | Phase 1 | 2026-04-22 | NCT04192981 | |
| Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases | Brain Metastases, Neoplasms by Site, Thoracic Neoplasms, brain disorder, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, central nervous system disorder, lung disorder, lung neoplasm, neoplasm, neoplastic meningitis, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasm, tumor of meninges | Active, not recruiting | Phase 4 | 2026-04-09 | NCT06282874 |