Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure Bipolar and Related Disorders, Schizophrenia Spectrum and Other Psychotic Disorders, bipolar disorder, depressive disorder, major depressive disorder, mood disorder, psychiatric disorder, schizophrenia Recruiting Phase 3 2026-01-22 NCT05603104 The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. Depressive Disorder, Treatment-Resistant, depressive disorder, major depressive disorder, mood disorder, psychiatric disorder Recruiting Phase 3 2025-09-26 NCT05973851 The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. Bipolar and Related Disorders, bipolar disorder, mood disorder, psychiatric disorder Recruiting Phase 3 2025-09-26 NCT05973786 The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. Psychotic Disorders, Schizophrenia Spectrum and Other Psychotic Disorders, psychiatric disorder, schizophrenia Recruiting Phase 4 2025-09-26 NCT05958875