Alnylam Pharmaceuticals
Alnylam Pharmaceuticals
Explore linked clinical trials.27 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting | Nutritional and Metabolic Diseases, amyloidosis, cardiomyopathy, cardiovascular disorder, heart disorder, metabolic disease, proteostasis deficiencies | Recruiting | Not stated | 2026-10-09 | NCT07358078 | |
| A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran | cardiovascular disorder, hypertensive disorder, vascular disorder | Recruiting | Phase 2 | 2026-10-08 | NCT07553442 | |
| TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy | Nutritional and Metabolic Diseases, amyloidosis, metabolic disease, nervous system disorder, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, proteostasis deficiencies | Recruiting | Phase 3 | 2026-10-08 | NCT07223203 | |
| A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease | Alzheimer disease, brain disorder, central nervous system disorder, cognitive disorder, dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Recruiting | Phase 1 | 2026-10-08 | NCT07214727 | |
| Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program | Amyloid Neuropathies, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Nutritional and Metabolic Diseases, amyloidosis, familial amyloid neuropathy, hereditary amyloidosis, hereditary disease, inborn errors of metabolism, inherited neurodegenerative disorder, metabolic disease, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, proteostasis deficiencies | Recruiting | Not stated | 2026-10-08 | NCT05040373 | |
| BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1) | primary hyperoxaluria type 1 | Active, not recruiting | Not stated | 2026-10-06 | NCT04982393 | |
| ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, Nutritional and Metabolic Diseases, Skin and Connective Tissue Diseases, hepatic porphyria, hereditary coproporphyria, hereditary disease, hereditary skin disorder, liver disorder, metabolic disease, porphyria, porphyria due to ALA dehydratase deficiency, skin disorder | Recruiting | Not stated | 2026-10-06 | NCT04883905 | |
| HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Hemic and Lymphatic Diseases, Hemorrhage, Menorrhagia, Menstruation Disturbances, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Urogenital Diseases, Uterine Hemorrhage, blood coagulation disease, blood platelet disease, coagulation protein disease, female reproductive system disorder, hematologic disorder, hemorrhagic disease, hereditary disease, inherited blood coagulation disorder, uterine disorder, von Willebrand disease (hereditary or acquired) | Recruiting | Phase 2 | 2026-09-18 | NCT07575308 | |
| Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease | cardiovascular disorder, hypertensive disorder, vascular disorder | Recruiting | Phase 3 | 2026-09-18 | NCT07181109 | |
| A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy | Nutritional and Metabolic Diseases, amyloidosis, brain disorder, cardiovascular disorder, central nervous system disorder, cerebral amyloid angiopathy, cerebral arterial disease, cerebrovascular disorder, intracranial arterial disease, metabolic disease, nervous system disorder, proteostasis deficiencies, vascular disorder | Active, not recruiting | Phase 2 | 2026-09-18 | NCT06393712 | |
| A Study to Evaluate ALN-4915 in Adult Healthy Volunteers | Healthy Volunteers | Recruiting | Phase 1 | 2026-09-16 | NCT07535606 | |
| A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus | Nutritional and Metabolic Diseases, diabetes mellitus, endocrine system disorder, glucose metabolism disease, metabolic disease, type 2 diabetes mellitus | Recruiting | Phase 2 | 2026-09-16 | NCT07465224 | |
| A Study to Evaluate ALN-2232 in Participants With Obesity | Body Weight, Nutritional and Metabolic Diseases, Overweight, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, nutritional disorder, obesity disorder, overnutrition | Recruiting | Phase 1 / Phase 2 | 2026-09-16 | NCT07463846 | |
| A Study to Evaluate ALN-4285 in Adult Healthy Volunteers | Healthy Volunteers | Recruiting | Phase 1 | 2026-09-16 | NCT07295717 | |
| TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy | Nutritional and Metabolic Diseases, amyloidosis, cardiomyopathy, cardiovascular disorder, heart disorder, metabolic disease, proteostasis deficiencies | Recruiting | Phase 3 | 2026-09-16 | NCT07052903 | |
| A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM | Body Weight, Nutritional and Metabolic Diseases, Overweight, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, diabetes mellitus, endocrine system disorder, glucose metabolism disease, metabolic disease, nutritional disorder, obesity disorder, overnutrition, type 2 diabetes mellitus | Active, not recruiting | Phase 1 / Phase 2 | 2026-09-16 | NCT06845202 | |
| A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT) | Cardiovascular Abnormalities, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Epistaxis, Hemic and Lymphatic Diseases, Hemorrhage, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Signs and Symptoms, Respiratory, cardiovascular disorder, hematologic disorder, hemorrhagic disease, hereditary hemorrhagic telangiectasia, nasal disorder, otorhinolaryngologic disease, respiratory system disorder, telangiectasis, vascular disorder, vascular hemostatic disease, vascular malformation | Active, not recruiting | Phase 1 / Phase 2 | 2026-09-16 | NCT06659640 | |
| A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease | Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Huntington disease, basal ganglia disorder, brain disorder, central nervous system disorder, choreatic disease, cognitive disorder, dementia, hereditary disease, inherited neurodegenerative disorder, movement disorder, nervous system disorder, neurodegenerative disease, psychiatric disorder | Recruiting | Phase 1 | 2026-09-16 | NCT06585449 | |
| A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD | Alzheimer disease, brain disorder, central nervous system disorder, cognitive disorder, dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Recruiting | Phase 1 | 2026-09-14 | NCT05231785 | |
| ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis) | Amyloid Neuropathies, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Nutritional and Metabolic Diseases, amyloidosis, familial amyloid neuropathy, hereditary amyloidosis, hereditary disease, inborn errors of metabolism, inherited neurodegenerative disorder, metabolic disease, nervous system disorder, neurodegenerative disease, neuromuscular disease, peripheral nervous system disorder, polyneuropathy, proteostasis deficiencies | Recruiting | Not stated | 2026-09-08 | NCT04561518 | |
| A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD) | Abnormalities, Multiple, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Down syndrome, Neurobehavioral Manifestations, Neurologic Manifestations, chromosomal disorder, hereditary disease, intellectual disability, nervous system disorder | Recruiting | Phase 2 | 2026-09-04 | NCT07636811 | |
| A Study to Evaluate ALN-6222 in Participants With Obesity | Body Weight, Nutritional and Metabolic Diseases, Overweight, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, nutritional disorder, obesity disorder, overnutrition | Recruiting | Phase 1 | 2026-09-03 | NCT07624071 | |
| Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF | Nutritional and Metabolic Diseases, amyloidosis, cardiovascular disorder, diastolic heart failure, familial amyloid neuropathy, heart disorder, heart failure, metabolic disease, proteostasis deficiencies | Recruiting | Not applicable | 2026-09-01 | NCT05577819 | |
| Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy | familial amyloid neuropathy | Active, not recruiting | Not stated | 2026-08-12 | NCT06360289 | |
| A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma | Digestive System Diseases, Digestive System Neoplasms, Liver Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, adenocarcinoma, carcinoma, epithelial neoplasm, hepatocellular carcinoma, liver disorder, neoplasm | Recruiting | Phase 1 | 2026-06-17 | NCT06600321 |