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Clinical trials

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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed GlioblastomaNeoplasms by Histologic Type, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, astrocytoma (excluding glioblastoma), epithelial neoplasm, glioblastoma, glioma, gliosarcoma, neoplasm, neuroepithelial neoplasm, primitive neuroectodermal tumorActive, not recruitingPhase 22026-09-29NCT05864534
A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and ChemotherapyDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colonic disorder, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal cancer, rectal disorder, rectal neoplasmRecruitingPhase 22026-09-22NCT07227636
The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-RadiationDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, endocrine system disorder, malignant endocrine neoplasm, neoplasm, pancreas disorder, pancreatic neoplasmRecruitingPhase 22026-08-21NCT06843551
RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, rectal neoplasmRecruitingPhase 22026-08-18NCT07735624
Ivermectin in Combination With Balstilimab or Pembrolizumab in Patients With Metastatic Triple Negative Breast CancerNeoplasms by Site, Skin and Connective Tissue Diseases, breast disorder, breast neoplasm, neoplasm, skin disorder, triple-negative breast carcinomaRecruitingPhase 1 / Phase 22026-08-05NCT05318469
KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colonic disorder, colonic neoplasm, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, intestinal disorder, malignant endocrine neoplasm, malignant pancreatic neoplasm, neoplasm, pancreas disorder, pancreatic neoplasm, rectal disorderRecruitingPhase 12026-07-31NCT06411691
AGEN1423 and Botensilimab w/ or w/o Chemo in PDACDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, endocrine system disorder, malignant endocrine neoplasm, malignant pancreatic neoplasm, neoplasm, pancreas disorder, pancreatic ductal adenocarcinoma, pancreatic neoplasmActive, not recruitingPhase 22026-07-09NCT05632328
Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric AdenocarcinomasDigestive System Diseases, Digestive System Neoplasms, Neoplasm Metastasis, Neoplasms by Site, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, digestive system disorder, digestive system neoplasm, gastric cancer, gastric neoplasm, metastatic malignant neoplasm, neoplasm, stomach disorderRecruitingPhase 32026-06-25NCT06346197
A Study of Botensilimab and Balstilimab for Rectal AdenocarcinomaLocally Advanced Rectal Adenocarcinoma; Microsatellite Stable Rectal CarcinomaRecruitingPhase 22026-06-16NCT06843434
Assessment of the Safety and Efficacy of Balstilimab in Combination With Botensilimab for the Treatment of Non-Small Cell Lung Cancer (IMMONC0008)Neoplasms by Site, Thoracic Neoplasms, bronchial neoplasm, bronchogenic carcinoma, lung disorder, lung neoplasm, neoplasm, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasmActive, not recruitingPhase 22026-06-08NCT06322108
Assessment of the Safety and Efficacy of Balstilimab for the Treatment of Relapsed/Refractory Lymphomas (IMMONC0001)Hemic and Lymphatic Diseases, Neoplasms by Histologic Type, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, neoplasmRecruitingPhase 22026-06-08NCT05891821
Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver MetastasesDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colonic disorder, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorderRecruitingPhase 22026-05-15NCT06300463
Botensilimab, Balstilimab, and SBRT in Colorectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colonic disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorderRecruitingEarly phase 12026-05-13NCT07128355
Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue SarcomasNeoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, neoplasm, sarcomaActive, not recruitingPhase 22026-04-20NCT04028063
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced CancerAdnexal Diseases, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Connective and Soft Tissue, Thoracic Neoplasms, Urogenital Diseases, Urogenital Neoplasms, angiosarcoma, bronchial neoplasm, bronchogenic carcinoma, endocrine system disorder, endometrium neoplasm, female reproductive system disorder, female reproductive system neoplasm, fibrolamellar hepatocellular carcinoma, gonadal disorder, lung disorder, lung neoplasm, male reproductive organ cancer, male reproductive system disorder, malignant endocrine neoplasm, neoplasm, non-small cell lung carcinoma, ovarian cancer, ovarian disorder, prostate cancer, prostate disorder, respiratory system disorder, respiratory tract neoplasm, sarcoma, uterine disorder, vascular cancerActive, not recruitingPhase 12026-03-30NCT03860272
Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology CombinationsResectable MMR-deficient Solid Tumors; Resectable MMR-proficient Solid TumorsRecruitingPhase 2 / Phase 32026-03-05NCT06279130
Botensilimab and Balstilimab Optimization in Colorectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasm Metastasis, Neoplasms by Site, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, colonic disorder, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorderActive, not recruitingPhase 22026-02-05NCT06268015
A Study of Botensilimab (AGEN1181) for the Treatment of Advanced MelanomaAdvanced MelanomaActive, not recruitingPhase 22026-01-16NCT05529316
Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, adenocarcinoma, carcinoma, endocrine system disorder, epithelial neoplasm, malignant endocrine neoplasm, malignant pancreatic neoplasm, neoplasm, pancreas disorder, pancreatic neoplasmRecruitingPhase 1 / Phase 22025-12-03NCT06782932
Vorbipiprant (CR6086) / Balstilimab (AGEN2034) Combination in Stage IV Refractory pMMR - MSS CRC, and Other Metastatic GI CancersDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colonic disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, gastric cancer, gastric neoplasm, intestinal disorder, neoplasm, rectal disorder, stomach disorderActive, not recruitingPhase 1 / Phase 22025-10-29NCT05205330
A Study of Botensilimab and Balstilimab for the Treatment of Colorectal CancerDigestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, autosomal dominant Parkinson disease 4, colonic disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder, type 1 diabetes mellitus 12Active, not recruitingPhase 22025-09-04NCT05608044
A Study of Evofosfamide in Combination with Zalifrelimab and BalstilimabDigestive System Diseases, Digestive System Neoplasms, Genital Diseases, Head and Neck Neoplasms, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Urogenital Diseases, Urogenital Neoplasms, carcinoma, endocrine system disorder, epithelial neoplasm, head and neck squamous cell carcinoma, male reproductive organ cancer, male reproductive system disorder, malignant endocrine neoplasm, metastatic prostate carcinoma, neoplasm, pancreas disorder, pancreatic neoplasm, prostate cancer, prostate disorder, squamous cell carcinomaRecruitingPhase 1 / Phase 22025-01-21NCT06782555
Study to Evaluate the Safety and Efficacy of Treatment With NLM-001 and Standard Chemotherapy Plus Zalifrelimab in Patients With Advanced Pancreatic Cancerpancreatic ductal adenocarcinomaActive, not recruitingPhase 1 / Phase 22024-12-30NCT04827953