Disc Medicine, Inc | ClinicalTrials HQ

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Trial	Conditions	Status	Phase	Updated	More info	NCT ID
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP	Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, Nutritional and Metabolic Diseases, Skin and Connective Tissue Diseases, erythropoietic protoporphyria, hepatic porphyria, hereditary disease, hereditary skin disorder, liver disorder, metabolic disease, porphyria, skin disorder	Enrolling by invitation	Phase 2 / Phase 3	2026-10-09		NCT05883748
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease	Recruiting	Phase 1	2026-10-05		NCT07187973
Study of DISC-0974-201 in Participants With IBD and Anemia	Digestive System Diseases, Hemic and Lymphatic Diseases, anemia, digestive system disorder, gastroenteritis, hematologic disorder, inflammatory bowel disease, intestinal disorder	Recruiting	Phase 2	2026-09-23		NCT07368972
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia	Hemic and Lymphatic Diseases, Myeloproliferative Disorders, anemia, bone marrow disorder, hematologic disorder, myelodysplastic syndrome, primary myelofibrosis	Recruiting	Phase 1 / Phase 2	2026-09-23		NCT05320198
A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)	Hemic and Lymphatic Diseases, Myeloproliferative Disorders, Neoplasms by Site, acquired polycythemia vera, bone marrow disorder, bone marrow neoplasm, hematologic disorder, hematopoietic and lymphoid system neoplasm, neoplasm	Active, not recruiting	Phase 2	2026-07-31		NCT06985147