California Institute for Regenerative Medicine (CIRM)
California Institute for Regenerative Medicine (CIRM)
Explore linked clinical trials.36 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients | AIDS, Blood-Borne Infections, Disease Attributes, Genital Diseases, HIV infectious disease, Infections, Pathologic Processes, Pathological Conditions, Signs and Symptoms, RNA Virus Infections, Slow Virus Diseases, Urogenital Diseases, immune system disorder, inborn error of immunity, infectious disease, lentivirus infection, sexually transmitted disease, uterine carcinosarcoma, viral infectious disease, viral sexually transmitted disease | Active, not recruiting | Phase 1 | 2026-10-02 | NCT02500849 | |
| A Phase IIb Randomized, Multicenter Trial of Subretinal CPCB-RPE1 in Advanced Dry AMD (Geographic Atrophy) | Geographic Atrophy, eye disorder, macular degeneration, retinal degeneration, retinal disorder | Recruiting | Phase 2 | 2026-09-23 | NCT06557460 | |
| B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme | Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, nervous system disorder | Recruiting | Phase 1 | 2026-09-15 | NCT05474378 | |
| A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, anemia, beta thalassemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease, thalassemia | Active, not recruiting | Phase 2 | 2026-08-25 | NCT05353647 | |
| Phase 1 Study of C.001 in Retinal Degeneration | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Eye Diseases, Hereditary, Geographic Atrophy, Stargardt disease, age-related macular degeneration, eye disorder, hereditary disease, macular degeneration, retinal degeneration, retinal disorder | Recruiting | Phase 1 | 2026-08-17 | NCT07594236 | |
| Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells | Neoplasms by Histologic Type, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, astrocytoma (excluding glioblastoma), epithelial neoplasm, glioblastoma, glioma, neoplasm, neuroepithelial neoplasm, primitive neuroectodermal tumor | Recruiting | Phase 1 | 2026-08-13 | NCT06186401 | |
| HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases | Neoplasms by Site, Skin and Connective Tissue Diseases, brain disorder, breast cancer, breast disorder, breast neoplasm, cancer, central nervous system cancer, central nervous system disorder, metastatic malignant neoplasm in the brain, neoplasm, neoplastic meningitis, nervous system disorder, skin disorder, tumor of meninges | Active, not recruiting | Phase 1 | 2026-08-12 | NCT03696030 | |
| Phase 1/2 Study of MZ-1866, an AAV-9 Gene Therapy Delivered by Intracerebroventricular Injection to Participants With Pitt Hopkins Syndrome | Pitt-Hopkins syndrome | Recruiting | Phase 1 / Phase 2 | 2026-07-31 | NCT07135050 | |
| A Study to Assess Safety and Efficacy of Surgical Implant of RNDP-001 in Patients With Idiopathic Parkinson's Disease | Idiopathic Parkinson´s Disease; Parkinson's Disease | Active, not recruiting | Phase 1 / Phase 2 | 2026-07-27 | NCT07106021 | |
| TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation | Living Donor Kidney Transplantation | Recruiting | Phase 1 | 2026-07-01 | NCT03943238 | |
| Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy)) | Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, epilepsy, nervous system disorder, visual epilepsy | Recruiting | Phase 3 | 2026-06-09 | NCT05135091 | |
| Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant | B-cell neoplasm, Blood-Borne Infections, Burkitt lymphoma, DNA Virus Infections, Epstein-Barr virus infection, Genital Diseases, HIV infectious disease, Hemic and Lymphatic Diseases, Herpesviridae infectious disease, Hodgkins lymphoma, Infections, Neoplasms by Histologic Type, RNA Virus Infections, T-cell non-Hodgkin lymphoma, Tumor Virus Infections, Urogenital Diseases, diffuse large B-cell lymphoma, follicular lymphoma, immune system disorder, immunoproliferative disorder, inborn error of immunity, infectious disease, lentivirus infection, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, mantle cell lymphoma, mature T-cell and NK-cell non-Hodgkin lymphoma, neoplasm, plasmablastic lymphoma, sexually transmitted disease, uterine carcinosarcoma, viral infectious disease, viral sexually transmitted disease | Active, not recruiting | Phase 1 / Phase 2 | 2026-05-18 | NCT02797470 | |
| Phase 1/2a Study of ANPD001 in Parkinson Disease | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Enrolling by invitation | Phase 1 | 2026-05-14 | NCT06344026 | |
| Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease | Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Huntington disease, basal ganglia disorder, brain disorder, central nervous system disorder, choreatic disease, cognitive disorder, dementia, hereditary disease, inherited neurodegenerative disorder, movement disorder, nervous system disorder, neurodegenerative disease, psychiatric disorder | Recruiting | Phase 1 / Phase 2 | 2026-04-13 | NCT07451613 | |
| Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors | Adenoma, Islet Cell, Digestive System Diseases, Digestive System Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Skin and Connective Tissue Diseases, Thoracic Neoplasms, Uveal Neoplasms, adenocarcinoma, adenoma, adrenal cortex disorder, adrenal cortex neoplasm, adrenal gland cancer, adrenal gland disorder, breast cancer, breast disorder, breast neoplasm, carcinoma, endocrine system disorder, epithelial neoplasm, eye disorder, head and neck squamous cell carcinoma, lung adenocarcinoma, lung neoplasm, malignant endocrine neoplasm, melanocytic neoplasm, melanoma, metastatic melanoma, neoplasm, neuroendocrine neoplasm, ocular cancer, pancreas disorder, pancreatic neoplasm, pancreatic neuroendocrine tumor, paraganglioma, pheochromocytoma, primitive neuroectodermal tumor, respiratory tract neoplasm, skin disorder, skin neoplasm, squamous cell carcinoma, thyroid gland disorder, thyroid tumor, uveal disorder, uveal melanoma | Recruiting | Phase 1 | 2026-03-17 | NCT04119024 | |
| DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma | Neoplasms by Histologic Type, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, epithelial neoplasm, glioma, malignant glioma, neoplasm, neuroepithelial neoplasm, primitive neuroectodermal tumor | Recruiting | Phase 1 / Phase 2 | 2026-03-11 | NCT06504381 | |
| A Blood Stem Cell Transplant for Sickle Cell Disease | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease, thalassemia | Active, not recruiting | Phase 1 | 2026-03-05 | NCT03249831 | |
| Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101 | Blood Protein Disorders, Hemic and Lymphatic Diseases, Neoplasms by Histologic Type, cardiovascular disorder, hematologic disorder, hemorrhagic disease, immune system disorder, immunoproliferative disorder, lymphoproliferative syndrome, monoclonal gammopathy, neoplasm, plasma cell neoplasm, vascular disorder, vascular hemostatic disease | Active, not recruiting | Phase 1 | 2026-03-04 | NCT03741127 | |
| Stem Cell Therapy for Limbal Stem Cell Deficiency | corneal disorder, eye disorder, limbal stem cell deficiency | Active, not recruiting | Phase 1 | 2026-02-10 | NCT03957954 | |
| GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG) | brain stem glioma | Recruiting | Phase 1 | 2026-01-26 | NCT04196413 | |
| Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial | Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, central nervous system malformation, myelomeningocele, nervous system disorder | Recruiting | Phase 1 / Phase 2 | 2026-01-20 | NCT04652908 | |
| Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Adults With T-allo10 Cells Addback | Hemic and Lymphatic Diseases, hematologic disorder | Recruiting | Phase 1 | 2026-01-08 | NCT04640987 | |
| Autologous Muscle Derived Cells for Treatment of Tongue Dysphagia | Deglutition Disorders, Digestive System Diseases, Oropharyngeal Dysphagia, Pharyngeal Diseases, digestive system disorder, esophageal disorder, otorhinolaryngologic disease | Active, not recruiting | Phase 1 / Phase 2 | 2025-12-12 | NCT05421689 | |
| Analysis of Coronavirus Disease 19 (COVID-19) Convalescent Plasma | Asymptomatic COVID-19 Infection Laboratory-Confirmed; Symptomatic COVID-19 Infection Laboratory-Confirmed | Active, not recruiting | Not stated | 2025-12-05 | NCT04497779 | |
| CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies | B-cell neoplasm, Burkitt lymphoma, DNA Virus Infections, Epstein-Barr virus infection, Hemic and Lymphatic Diseases, Herpesviridae infectious disease, Infections, Neoplasm, Residual, Neoplasms by Histologic Type, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Tumor Virus Infections, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, neoplasm, viral infectious disease | Active, not recruiting | Phase 1 | 2025-11-18 | NCT03233854 |