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Michael J. Fox Foundation for Parkinson's Research

Michael J. Fox Foundation for Parkinson's Research

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Clinical trials

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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
The Efficacy of Psilocybin Therapy for Depression in Parkinson's DiseaseParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, depressive disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingPhase 22026-09-28NCT07610369
This Protocol is a Sub-study Under the PPMI Program. It is a Longitudinal, Single-center Study to Assess the Performance of [18F]AV-133 Imaging Using High and Standard Resolution PET in Individuals Enrolled With Parkinson's Disease (PD) for up to 12 Months.Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingPhase 22026-09-21NCT07830654
Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's DiseaseParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingPhase 22026-09-21NCT07005180
A Phase I Study in Healthy Volunteers and Parkinson's Disease (PD) Patients.Hemic and Lymphatic Diseases, Neoplasms by Histologic Type, Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, follicular lymphoma, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, movement disorder, neoplasm, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingPhase 12026-09-15NCT07630545
A Comparative Performance Study Between High and Standard Resolution Positron Emission Tomography Camera Using [18F] AV-133 in Prodromal Parkinson's DiseaseProdromal Parkinson's DiseaseRecruitingPhase 22026-09-09NCT07809438
Parkinson Progression Marker Initiative Online (PPMI Online)Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingNot stated2026-09-08NCT05065060
Slow-SPEED: Slowing Parkinson's Early Through Exercise DosageDisease Attributes, Nutritional and Metabolic Diseases, Parkinson disease, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Prodromal Stage, Prodromal Symptoms, Signs and Symptoms, basal ganglia disorder, brain disorder, central nervous system disorder, disease susceptibility, inherited disease susceptibility, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, proteostasis deficiencies, synucleinopathyRecruitingNot applicable2026-08-27NCT06993142
Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-NetherlandsNutritional and Metabolic Diseases, Parasomnias, Parkinson disease, Pathological Conditions, Signs and Symptoms, Prodromal Stage, Prodromal Symptoms, REM Sleep Parasomnias, REM sleep behavior disorder, Signs and Symptoms, basal ganglia disorder, brain disorder, central nervous system disorder, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, proteostasis deficiencies, psychiatric disorder, sleep-wake disorder, synucleinopathyRecruitingNot applicable2026-08-27NCT06193252
CnF-DBS for Levodopa-Resistant FOGFreezing of Gait Symptoms in Parkinson DiseaseNot yet recruitingNot applicable2026-08-24NCT07781696
A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson DiseaseParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingNot applicable2026-08-24NCT07705373
Longitudinal TSPO PET Imaging With [18F]DPA-714 in PPMI (PPMI DPA-714 PET Imaging)Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingEarly phase 12026-08-12NCT06289582
Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's DiseaseParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingPhase 22026-08-10NCT07020026
PPMI Clinical - Establishing a Deeply Phenotyped PD CohortNeurologic Manifestations, Parkinson disease, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, anosmia, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingNot stated2026-07-27NCT04477785
Neuro-immune Interactome in Parkinson's DiseaseParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyActive, not recruitingNot stated2026-07-21NCT07026929
Safety, Tolerability and Exploratory Efficacy of EC5026 in Parkinson's Disease (STEP Study)Parkinson's Disease (PD)RecruitingPhase 1 / Phase 22026-07-10NCT07142044
Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD MutationParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingNot stated2026-06-11NCT07642908
AID-FOG: Artificial Intelligence-Driven Freezing of Gait Detection in the HomeParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingNot stated2026-05-12NCT07580612
Adaptive Deep Brain Stimulation to Improve Motor and Gait Functions in Parkinson's DiseaseParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyActive, not recruitingNot applicable2026-05-01NCT04675398
Movement State-dependent Adaptive DBS for PDParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyEnrolling by invitationNot applicable2026-04-29NCT07424508
Neuroimaging of Parkinson'sParkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingNot stated2026-04-13NCT07024875
Genotypic Influences on Network Progression in Parkinson's DiseaseDisease Attributes, Disease Progression, Parkinson disease, Pathologic Processes, Pathological Conditions, Signs and Symptoms, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyActive, not recruitingNot stated2026-04-13NCT04228172
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)brain disorder, central nervous system disorder, hydrocephalus, nervous system disorder, normal pressure hydrocephalusRecruitingNot stated2026-03-27NCT07103681
Black and African Americans Connections to Parkinson's Disease (BLAAC PD)Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathyRecruitingNot stated2026-02-27NCT06719583
Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's DiseaseParasomnias, Parkinson disease, REM Sleep Parasomnias, REM sleep behavior disorder, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, psychiatric disorder, sleep-wake disorder, synucleinopathyActive, not recruitingNot stated2026-02-11NCT06621602
Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)Prodromal Parkinsons DiseaseRecruitingPhase 22025-12-05NCT07265596