Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Explore linked clinical trials.18 results · Page 1 of 1
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| A Study to Assess the Effects of Probenecid on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants | Healthy | Recruiting | Phase 1 | 2026-10-09 | NCT07840612 | |
| A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, desmoid tumor, fibroma, neoplasm | Active, not recruiting | Phase 2 | 2026-10-01 | NCT04195399 | |
| Phase 1 Single Ascending Doses (SAD) of M5542 in Healthy Participants | Healthy | Recruiting | Phase 1 | 2026-09-21 | NCT06577337 | |
| A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma | Neoplasms by Histologic Type, Neoplasms, Adipose Tissue, Neoplasms, Connective and Soft Tissue, Well Differentiated Liposarcoma, liposarcoma, myxoid liposarcoma, neoplasm, sarcoma | Recruiting | Phase 1 / Phase 2 | 2026-09-16 | NCT06843967 | |
| Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad) | Neoplasms by Site, Paraneoplastic Syndromes, Nervous System, autoimmune disease, autoimmune disorder of the nervous system, immune system disorder, myasthenia gravis, neoplasm, nervous system disorder, neurodegenerative disease, neuromuscular disease, neuromuscular junction disease, paraneoplastic syndrome | Recruiting | Phase 3 | 2026-09-16 | NCT06463587 | |
| SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma | Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, astrocytoma (excluding glioblastoma), brain disorder, central nervous system cancer, central nervous system disorder, central neurocytoma, epithelial neoplasm, ganglioglioma, glioma, low grade glioma, neoplasm, nervous system disorder, neuroepithelial neoplasm, oligodendroglioma, primitive neuroectodermal tumor | Recruiting | Phase 1 / Phase 2 | 2026-09-11 | NCT04923126 | |
| Study of Pimicotinib in Japanese Participants With Tenosynovial Giant Cell Tumor (TGCT) (J-MANEUVER) | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, arthropathy, connective tissue neoplasm, disease of the tendon, giant cell tumor, muscle tissue disorder, musculoskeletal system disorder, neoplasm, synovitis, tenosynovial giant cell tumor | Recruiting | Phase 2 | 2026-09-10 | NCT07499362 | |
| Study of Cryoablation and Nirogacestat for Desmoid Tumor | Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue, connective tissue neoplasm, desmoid tumor, fibroma, neoplasm | Recruiting | Phase 2 | 2026-09-10 | NCT05949099 | |
| A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA) | Genital Diseases, Urogenital Diseases, infertility disorder | Recruiting | Phase 3 | 2026-09-08 | NCT07340827 | |
| A Study of Mirdametinib in People With Central Nervous System Tumors | Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, central nervous system cancer, epithelial neoplasm, glioma, neoplasm, nervous system disorder, neuroepithelial neoplasm, primitive neuroectodermal tumor | Recruiting | Phase 1 / Phase 2 | 2026-09-03 | NCT07539441 | |
| Anti-CEACAM5 ADC Precemtabart Tocentecan (M9140) in Chinese Participants With Solid Tumors | Digestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, colonic disorder, colorectal cancer, colorectal neoplasm, digestive system disorder, digestive system neoplasm, intestinal disorder, neoplasm, rectal disorder | Active, not recruiting | Phase 1 | 2026-08-11 | NCT06806046 | |
| Evaluation of the Response and Non-response of Nirogacestat in Desmoid Tumors- Clinical Study | neoplasm | Recruiting | Phase 2 | 2026-08-10 | NCT05879146 | |
| Cladribine Tablets Level of Response Predictors in Clinical Practice (CLODINA) | CNS demyelinating autoimmune disease, autoimmune disease, autoimmune disorder of the nervous system, demyelinating disease, immune system disorder, multiple sclerosis, nervous system disorder | Active, not recruiting | Not stated | 2026-08-07 | NCT05797740 | |
| Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor) | Digestive System Diseases, Digestive System Neoplasms, Neoplasms by Site, Thoracic Neoplasms, bronchial neoplasm, bronchogenic carcinoma, digestive system disorder, digestive system neoplasm, endocrine system disorder, gastric cancer, gastric neoplasm, lung disorder, lung neoplasm, malignant endocrine neoplasm, malignant pancreatic neoplasm, neoplasm, non-small cell lung carcinoma, pancreas disorder, pancreatic neoplasm, respiratory system disorder, respiratory tract neoplasm, stomach disorder | Active, not recruiting | Phase 1 / Phase 2 | 2026-07-30 | NCT06710132 | |
| Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma | Neoplasm Metastasis, Neoplasms by Histologic Type, Neoplasms, Connective and Soft Tissue, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Anatomical, Pathological Conditions, Signs and Symptoms, Tertiary Lymphoid Structures, neoplasm, sarcoma | Active, not recruiting | Phase 2 | 2026-07-24 | NCT04874311 | |
| The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE) | Skin and Connective Tissue Diseases, autoimmune disease, connective tissue disorder, cutaneous lupus erythematosus, discoid lupus erythematosus, immune system disorder, skin disorder, systemic lupus erythematosus | Active, not recruiting | Phase 2 | 2026-07-20 | NCT05540327 | |
| Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF). | neurofibromatosis type 1 | Recruiting | Phase 1 / Phase 2 | 2026-04-13 | NCT06159166 | |
| Avelumab and Methotrexate in in Low-risk Gestational Trophoblastic Neoplasias as First Line Treatment | Gestational Trophoblastic Neoplasias (GTN) | Recruiting | Phase 1 / Phase 2 | 2024-02-29 | NCT04396223 |