Kyverna Therapeutics
Kyverna Therapeutics
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Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| CARTIMMUNE: Study of Patients With Autoimmune Diseases Receiving KYV-101 | Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Skin and Connective Tissue Diseases, Urogenital Diseases, acquired idiopathic inflammatory myopathy, anti-neutrophil cytoplasmic antibody-associated vasculitis, autoimmune disease, cardiovascular disorder, connective tissue disorder, diffuse scleroderma, glomerulonephritis, immune system disorder, kidney disorder, lupus nephritis, muscle tissue disorder, musculoskeletal system disorder, myositis disease, necrotizing vasculitis, nephritis, nervous system disorder, neuromuscular disease, skin disorder, skin vascular disease, systemic lupus erythematosus, systemic sclerosis, urinary system disorder, vascular disorder, vasculitis | Active, not recruiting | Phase 1 | 2026-09-21 | NCT06152172 | |
| A Study of KYV-101, a CD19 CAR T Cell Therapy, in Participants With Treatment Refractory Progressive Multiple Sclerosis | CNS demyelinating autoimmune disease, Chronic Disease, Disease Attributes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, autoimmune disease, autoimmune disorder of the nervous system, chronic progressive multiple sclerosis, demyelinating disease, immune system disorder, multiple sclerosis, nervous system disorder | Active, not recruiting | Phase 1 | 2026-08-10 | NCT06451159 | |
| KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis | Neoplasms by Site, Paraneoplastic Syndromes, Nervous System, autoimmune disease, autoimmune disorder of the nervous system, immune system disorder, myasthenia gravis, neoplasm, nervous system disorder, neurodegenerative disease, neuromuscular disease, neuromuscular junction disease, paraneoplastic syndrome | Recruiting | Phase 2 / Phase 3 | 2026-07-29 | NCT06193889 | |
| Comparison of B-cell Depletion by Rituximab and Anti-CD 19 CAR-T Therapy in Patients With Rheumatoid Arthritis | Skin and Connective Tissue Diseases, arthritic joint disease, arthropathy, autoimmune disease, connective tissue disorder, immune system disorder, musculoskeletal system disorder, rheumatic disorder, rheumatoid arthritis | Active, not recruiting | Phase 1 / Phase 2 | 2026-03-05 | NCT06475495 | |
| A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis | CNS demyelinating autoimmune disease, Chronic Disease, Disease Attributes, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive, Pathologic Processes, Pathological Conditions, Signs and Symptoms, autoimmune disease, autoimmune disorder of the nervous system, chronic progressive multiple sclerosis, demyelinating disease, immune system disorder, multiple sclerosis, nervous system disorder | Recruiting | Phase 1 | 2026-02-27 | NCT06138132 | |
| A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101 | CNS demyelinating autoimmune disease, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Skin and Connective Tissue Diseases, Urogenital Diseases, arthritic joint disease, arthropathy, autoimmune disease, autoimmune disorder of the nervous system, central nervous system disorder, connective tissue disorder, demyelinating disease, dermatomyositis, glomerulonephritis, immune system disorder, kidney disorder, lupus nephritis, multiple sclerosis, muscle tissue disorder, musculoskeletal system disorder, myositis disease, nephritis, nervous system disorder, neuromuscular disease, polymyositis, rheumatic disorder, rheumatoid arthritis, skin disorder, spinal cord disorder, stiff-person syndrome, systemic lupus erythematosus, systemic sclerosis, urinary system disorder | Recruiting | Not stated | 2026-02-11 | NCT07403188 | |
| KYSA-7: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis | CNS demyelinating autoimmune disease, Chronic Disease, Disease Attributes, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive, Pathologic Processes, Pathological Conditions, Signs and Symptoms, autoimmune disease, autoimmune disorder of the nervous system, chronic progressive multiple sclerosis, demyelinating disease, immune system disorder, multiple sclerosis, nervous system disorder | Active, not recruiting | Phase 2 | 2025-01-13 | NCT06384976 | |
| Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Blood-Borne Infections, Genital Diseases, HIV Seropositivity, HIV infectious disease, Infections, RNA Virus Infections, Urogenital Diseases, cardiovascular disorder, immune system disorder, inborn error of immunity, infectious disease, lentivirus infection, sexually transmitted disease, uterine carcinosarcoma, vascular disorder, vasculitis, viral infectious disease, viral sexually transmitted disease | Not yet recruiting | Phase 1 / Phase 2 | 2024-09-19 | NCT06590545 |