Centessa Pharmaceuticals (UK) Limited | ClinicalTrials HQ

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Trial	Conditions	Status	Phase	Updated	More info	NCT ID
A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence	Cataplexy, Disorders of Excessive Somnolence, Dyssomnias, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Sleep Disorders, Intrinsic, Sleepiness, narcolepsy, narcolepsy without cataplexy, narcolepsy-cataplexy syndrome, nervous system disorder, psychiatric disorder, sleep-wake disorder	Recruiting	Phase 2 / Phase 3	2026-10-02		NCT07598708
A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia	Disorders of Excessive Somnolence, Dyssomnias, Sleep Disorders, Intrinsic, idiopathic hypersomnia, narcolepsy without cataplexy, narcolepsy-cataplexy syndrome, nervous system disorder, psychiatric disorder, sleep-wake disorder	Recruiting	Phase 2	2026-04-27		NCT06752668
A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia	Disorders of Excessive Somnolence, Dyssomnias, Sleep Disorders, Intrinsic, idiopathic hypersomnia, narcolepsy, narcolepsy without cataplexy, narcolepsy-cataplexy syndrome, nervous system disorder, psychiatric disorder, sleep-wake disorder	Recruiting	Phase 2	2026-04-16		NCT07096674
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years	Healthy Adult Male and Female Volunteers	Recruiting	Phase 1	2026-02-25		NCT07413666
A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age	Disorders of Excessive Somnolence, Dyssomnias, Excessive Daytime Sleepiness, Sleep Disorders, Intrinsic, nervous system disorder, psychiatric disorder, sleep-wake disorder	Recruiting	Phase 1	2025-12-24		NCT07082829