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Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years | Epilepsy, Generalized, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, brain disorder, central nervous system disorder, epilepsy, idiopathic generalized epilepsy, nervous system disorder, visual epilepsy | Not yet recruiting | Not applicable | 2026-09-04 | NCT07803692 | |
| EMBRACE Tremor BiFUS | central nervous system disorder, essential tremor, movement disorder, nervous system disorder | Recruiting | Not applicable | 2026-08-31 | NCT06974916 | |
| Unilateral and Staged Bilateral Pallidothalamic Tractotomy Using Exablate MRgFUS in Advanced Parkinson's Disease. | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Not yet recruiting | Not applicable | 2026-08-24 | NCT07764874 | |
| Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets | Neoplasms by Site, Thoracic Neoplasms, brain disorder, bronchial neoplasm, bronchogenic carcinoma, central nervous system cancer, central nervous system disorder, lung disorder, lung neoplasm, neoplasm, nervous system disorder, non-small cell lung carcinoma, respiratory system disorder, respiratory tract neoplasm | Recruiting | Phase 3 | 2026-08-19 | NCT05317858 | |
| MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia | Stomatognathic Diseases, cranial nerve neuropathy, facial nerve disorder, facial neuralgia, mouth disorder, nervous system disorder, trigeminal nerve disorder, trigeminal neuralgia | Active, not recruiting | Not applicable | 2026-07-20 | NCT04579692 | |
| A Feasibility Safety Study of Benign Centrally-Located Intracranial Tumors in Pediatric and Young Adult Subjects | congenital hypothalamic hamartoma syndrome, hamartoma, neoplasm | Recruiting | Not applicable | 2026-06-29 | NCT03028246 | |
| Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs) | Chemically-Induced Disorders, Narcotic-Related Disorders, Substance Use Disorders, opiate dependence, psychiatric disorder, substance-related disorder | Recruiting | Not applicable | 2026-06-26 | NCT04197921 | |
| A Prospective, Randomized, Controlled Trial to Test Safety and Effectiveness of Unilateral Exablate MR-guided Focused Ultrasound Subthalamotomy in Patients With Early-Stage Parkinson's Disease | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Active, not recruiting | Not applicable | 2026-05-06 | NCT06584383 | |
| Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG | Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorder | Active, not recruiting | Phase 1 / Phase 2 | 2026-04-21 | NCT05615623 | |
| Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG) | Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorder | Active, not recruiting | Phase 1 / Phase 2 | 2026-04-17 | NCT05630209 | |
| A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Recruiting | Not stated | 2026-03-20 | NCT05539196 | |
| A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease | Tremor Associated With Tremor Dominant Parkinson's Disease | Recruiting | Not stated | 2026-03-20 | NCT04991831 | |
| ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Active, not recruiting | Not applicable | 2026-03-20 | NCT03319485 | |
| MRgFUS Pallidotomy for the Treatment of Task Specific Focal Hand Dystonia (TSFD) | dystonia, focal, task-specific | Recruiting | Not applicable | 2026-02-27 | NCT06367608 | |
| MR-guided Focused Ultrasound Plus GCase | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Recruiting | Not applicable | 2026-01-23 | NCT05565443 | |
| Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy | Alzheimer disease type 1, Cognition Disorders, Cognitive Dysfunction, Mild Cognitive Impairment, cognitive disorder, psychiatric disorder | Active, not recruiting | Early phase 1 | 2026-01-22 | NCT05469009 | |
| ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease | Alzheimer disease, brain disorder, central nervous system disorder, cognitive disorder, dementia, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy | Recruiting | Not applicable | 2026-01-09 | NCT03671889 | |
| Focused Ultrasound for Drug-resistant Epilepsy | Drug Resistant Epilepsy, brain disorder, central nervous system disorder, epilepsy, nervous system disorder | Recruiting | Not applicable | 2025-09-09 | NCT06292494 | |
| Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders: | Dyskinesias, Neurologic Manifestations, Pain, Parkinson disease, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Tremor, basal ganglia disorder, brain disorder, central nervous system disorder, essential tremor, movement disorder, nervous system disorder, neuralgia, neurodegenerative disease, neuromuscular disease, parkinsonian disorder, peripheral nervous system disorder, synucleinopathy | Active, not recruiting | Not stated | 2025-05-02 | NCT03100474 | |
| Bilateral Treatment of Medication Refractory Essential Tremor | central nervous system disorder, essential tremor, movement disorder, nervous system disorder | Active, not recruiting | Not applicable | 2025-05-01 | NCT04112381 | |
| Continued Access of Focal MR-Guided Focused Ultrasound for Localized Intermediate Risk Prostate Lesions | Genital Diseases, Male Urogenital Diseases, Neoplasms by Site, Urogenital Diseases, Urogenital Neoplasms, male reproductive organ cancer, male reproductive system disorder, neoplasm, prostate cancer, prostate disorder | Active, not recruiting | Not applicable | 2025-05-01 | NCT03998657 | |
| ExAblate Transcranial MRgFUS for Unilateral Pallidotomy for the Treatment of Parkinson's Disease | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Active, not recruiting | Not applicable | 2025-05-01 | NCT02347254 | |
| Blood-Brain Barrier Disruption Using Transcranial MRI-Guided Focused Ultrasound | Neoplasms by Site, brain disorder, central nervous system cancer, central nervous system disorder, neoplasm, nervous system disorder | Active, not recruiting | Not applicable | 2025-05-01 | NCT02343991 | |
| ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, Dyskinesias, Huntington disease, Neurologic Manifestations, Nutritional and Metabolic Diseases, Orofacial Dyskinesia, Parkinson disease, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Wilson disease, atactic disorder, non-human animal, basal ganglia disorder, brain disorder, central nervous system disorder, choreatic disease, cognitive disorder, dementia, drug-induced dyskinesia, dystonic disorder, essential tremor, hereditary disease, inborn errors of metabolism, inborn metal metabolism disorder, inherited neurodegenerative disorder, liver disorder, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, psychiatric disorder, synucleinopathy, tardive dyskinesia | Active, not recruiting | Not applicable | 2025-05-01 | NCT02252380 | |
| ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) Treatment of Brain Tumors | Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, brain disorder, central nervous system cancer, central nervous system disorder, epithelial neoplasm, glioma, neoplasm, nervous system disorder, neuroepithelial neoplasm, primitive neuroectodermal tumor | Active, not recruiting | Not applicable | 2025-05-01 | NCT01473485 |