Phase 1 trials
Phase 1 trials
Explore registered studies and their research locations.6,824 results · Page 1 of 273
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy Adults | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Friedreich ataxia, Mitochondrial Dysfunction, Nutritional and Metabolic Diseases, Spinocerebellar Degenerations, brain disorder, cardiomyopathy, cardiovascular disorder, central nervous system disorder, cerebellar disorder, heart disorder, hereditary disease, inborn mitochondrial metabolism disorder, inherited neurodegenerative disorder, metabolic disease, nervous system disorder, neurodegenerative disease, neuromuscular disease, spinal cord disorder | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07869654 | |
| BLinatumomab and iNKT in Relapsed B-Cell ALL | B-cell neoplasm, Burkitt lymphoma, DNA Virus Infections, Disease Attributes, Disease Progression, Epstein-Barr virus infection, Hemic and Lymphatic Diseases, Herpesviridae infectious disease, Infections, Neoplasm, Residual, Neoplasms by Histologic Type, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Tumor Virus Infections, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, neoplasm, viral infectious disease | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07869368 | |
| A Phase I, Randomized, Double-Blind, Placebo-Controlled Study of EQ504 in Single and Multiple Ascending Doses in Healthy Volunteers | Digestive System Diseases, colitis, colonic disorder, digestive system disorder, gastroenteritis, inflammatory bowel disease, intestinal disorder, ulcerative colitis | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07869225 | |
| Absorption, Distribution, Metabolism, and Excretion of 14C-VX-407 After a Single Oral Dose | Abnormalities, Multiple, Ciliopathies, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Urogenital Diseases, autosomal dominant polycystic kidney disease, cystic kidney disease, hereditary disease, kidney disorder, polycystic kidney disease, urinary system disorder | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07868926 | |
| A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults | Nausea, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Postoperative Complications, Postoperative Nausea and Vomiting, Signs and Symptoms, Signs and Symptoms, Digestive, Vomiting | Recruiting | Phase 1 | 2026-10-09 | NCT07868861 | |
| A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication | Body Weight, Nutritional and Metabolic Diseases, Overweight, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, diabetes mellitus, endocrine system disorder, glucose metabolism disease, metabolic disease, nutritional disorder, obesity disorder, overnutrition, type 2 diabetes mellitus | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07868354 | |
| A Study of Single and Multiple Doses of LY5625573 in Healthy Participants, Including Japanese and Chinese Populations, and Participants With Inflammation (High C-Reactive Protein) | C-Reactive Protein | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07867340 | |
| A Study of LY4515100 in Healthy Male Participants | Healthy | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07867327 | |
| A Phase 1, Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HTX-001 | Nonobstructive Hypertrophic Cardiomyopathy | Recruiting | Phase 1 | 2026-10-09 | NCT07867288 | |
| A Study to Evaluate the Effects of GDC-4198 in Combination With Letrozole, Fulvestrant, or Giredestrant in Participants With Locally Advanced or Metastatic Hormone Receptor-Positive, HER2-Negatve Breast Cancer | Neoplasms by Site, Skin and Connective Tissue Diseases, breast disorder, breast neoplasm, neoplasm, skin disorder | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07867262 | |
| A Study to Investigate the Effects of Moderate or Severe Renal Impairment (RI) on Velzatinib | Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Neoplasms by Site, Urogenital Diseases, digestive system disorder, digestive system neoplasm, kidney disorder, kidney failure, neoplasm, urinary system disorder | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07867171 | |
| TMZ + RT + 5-ALA + LIDU SDT System for Newly Diagnosed Butterfly Glioma | Neoplasms by Histologic Type, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, astrocytoma (excluding glioblastoma), epithelial neoplasm, glioblastoma, glioma, neoplasm, neuroepithelial neoplasm, primitive neuroectodermal tumor | Recruiting | Phase 1 | 2026-10-09 | NCT07862647 | |
| Comparative Study of QL1209 and Perjeta® in Healthy Male Participants | Neoplasms by Site, Skin and Connective Tissue Diseases, breast cancer, breast disorder, breast neoplasm, neoplasm, skin disorder | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07861139 | |
| First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy Volunteers | Healthy | Recruiting | Phase 1 | 2026-10-09 | NCT07853781 | |
| A Study to Assess the Effects of Probenecid on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants | Healthy | Recruiting | Phase 1 | 2026-10-09 | NCT07840612 | |
| A Study of LY5625575 in Healthy Participants and in Participants With Inflammation (Elevated C-Reactive Protein) | C-Reactive Protein; Healthy Volunteers | Recruiting | Phase 1 | 2026-10-09 | NCT07801300 | |
| Dynamic Magnetic Resonance Imaging of Human Subarachnoid Space Using Intrathecal Gadolinium Contrast | Healthy Volunteers | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07796360 | |
| Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults | HIV | Recruiting | Phase 1 | 2026-10-09 | NCT07757802 | |
| A Study of Subcutaneously Administered RO7845860 in Participants With Relapsing Multiple Sclerosis | Relapsing Multiple Sclerosis | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07749157 | |
| A Study Investigating the Safety of RO7795081 and How the Body Processes RO7795081 in People With Normal or Decreased Kidney Functions | Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Male Urogenital Diseases, Urogenital Diseases, kidney disorder, kidney failure, urinary system disorder | Recruiting | Phase 1 | 2026-10-09 | NCT07741604 | |
| Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy | Digestive System Diseases, Digestive System Neoplasms, Neoplasm Metastasis, Neoplasms by Histologic Type, Neoplasms by Site, Neoplastic Processes, Pathologic Processes, Pathological Conditions, Signs and Symptoms, adenocarcinoma, adrenal cortex disorder, adrenal cortex neoplasm, adrenal gland cancer, adrenal gland disorder, carcinoma, cholangiocarcinoma, colonic disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, epithelial neoplasm, intestinal disorder, intrahepatic cholangiocarcinoma, malignant endocrine neoplasm, neoplasm, rectal disorder | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07715903 | |
| Safety of Topical Exosome-Containing Liquid in Healthy Volunteers | Healthy Volunteers; Skin Irritation | Active, not recruiting | Phase 1 | 2026-10-09 | NCT07703969 | |
| Safety and Immunogenicity of Chimeric Hemagglutinin mRNA Vaccine Candidates | Infections, RNA Virus Infections, influenza, respiratory system disorder, respiratory tract infectious disorder, viral infectious disease | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07703514 | |
| A Safety, Reactogenicity and Immunogenicity Trial of RVX-sCPD9 Booster Intranasal COVID-19 Vaccine | COVID-19, Coronaviridae Infections, Infections, Nidovirales infectious disease, Orthocoronavirinae infectious disease, RNA Virus Infections, lung disorder, pneumonia, respiratory system disorder, respiratory tract infectious disorder, viral infectious disease, viral pneumonia | Not yet recruiting | Phase 1 | 2026-10-09 | NCT07703475 | |
| Lymphodepletion With Low Dose Total Body Irradiation Before Standard of Care Tisagenlecleucel for the Treatment of Relapsed and Recurrent Large B-cell Lymphoma | B-cell neoplasm, Hemic and Lymphatic Diseases, Neoplasms by Histologic Type, diffuse large B-cell lymphoma, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, neoplasm | Recruiting | Phase 1 | 2026-10-09 | NCT07676877 |