University of Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania, United States23 results · Page 1 of 1
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD) | Nutritional and Metabolic Diseases, Parasomnias, REM Sleep Parasomnias, REM sleep behavior disorder, metabolic disease, nervous system disorder, neurodegenerative disease, proteostasis deficiencies, psychiatric disorder, sleep-wake disorder, synucleinopathy | Recruiting | Phase 2 | 2026-10-08 | NCT06996652 | |
| A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease | Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Huntington disease, basal ganglia disorder, brain disorder, central nervous system disorder, choreatic disease, cognitive disorder, dementia, hereditary disease, inherited neurodegenerative disorder, movement disorder, nervous system disorder, neurodegenerative disease, psychiatric disorder | Recruiting | Phase 3 | 2026-09-22 | NCT07326709 | |
| Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study | brain disorder, central nervous system disorder, headache disorder, hypnic headache, migraine disorder, migraine with aura, nervous system disorder | Recruiting | Phase 4 | 2026-09-16 | NCT06972056 | |
| A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease | Parkinson disease, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Active, not recruiting | Phase 2 | 2026-09-11 | NCT03100149 | |
| CnF-DBS for Levodopa-Resistant FOG | Freezing of Gait Symptoms in Parkinson Disease | Not yet recruiting | Not applicable | 2026-08-24 | NCT07781696 | |
| Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Machado-Joseph disease, Neurologic Manifestations, Spinocerebellar Ataxias, Spinocerebellar Degenerations, Spinocerebellar ataxia 8, atactic disorder, non-human animal, brain disorder, central nervous system disorder, cerebellar ataxia, cerebellar disorder, hereditary disease, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, spinal cord disorder, spinocerebellar ataxia 7, spinocerebellar ataxia type 1, spinocerebellar ataxia type 10, spinocerebellar ataxia type 2, spinocerebellar ataxia type 6, spinocerebellar ataxia type 8 | Recruiting | Not stated | 2026-08-03 | NCT01060371 | |
| Responsive Neurostimulation For Loss Of Control Eating | Body Weight, Nutritional and Metabolic Diseases, Overweight, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, morbid obesity, nutritional disorder, obesity disorder, overnutrition | Active, not recruiting | Not applicable | 2026-07-29 | NCT03868670 | |
| PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort | Neurologic Manifestations, Parkinson disease, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, anosmia, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Recruiting | Not stated | 2026-07-27 | NCT04477785 | |
| HEALEY ALS Platform Trial - Master Protocol | Nutritional and Metabolic Diseases, TDP-43 proteinopathy, amyotrophic lateral sclerosis, central nervous system disorder, metabolic disease, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, proteostasis deficiencies, spinal cord disorder | Active, not recruiting | Phase 2 / Phase 3 | 2026-07-21 | NCT04297683 | |
| A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA) | autonomic nervous system disorder, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, multiple system atrophy, nervous system disorder, neurodegenerative disease, primary dysautonomia, synucleinopathy | Active, not recruiting | Phase 3 | 2026-07-14 | NCT06706622 | |
| Troriluzole in Adult Participants With Spinocerebellar Ataxia | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Machado-Joseph disease, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Spinocerebellar Ataxias, Spinocerebellar Degenerations, Spinocerebellar ataxia 8, atactic disorder, non-human animal, brain disorder, cardiac arrest, cardiovascular disorder, central nervous system disorder, cerebellar ataxia, cerebellar disorder, heart disorder, hereditary disease, inherited neurodegenerative disorder, nervous system disorder, neurodegenerative disease, spinal cord disorder, spinocerebellar ataxia 7, spinocerebellar ataxia type 1, spinocerebellar ataxia type 10, spinocerebellar ataxia type 2, spinocerebellar ataxia type 6, spinocerebellar ataxia type 8 | Active, not recruiting | Phase 3 | 2026-06-24 | NCT03701399 | |
| TRIAL READY (Clinical Trial Readiness) | Frontotemporal Lobar Degeneration, Nutritional and Metabolic Diseases, TDP-43 proteinopathy, amyotrophic lateral sclerosis, brain disorder, central nervous system disorder, cognitive disorder, dementia, frontotemporal dementia, lateral sclerosis, metabolic disease, motor neuron disorder, nervous system disorder, neurodegenerative disease, neuromuscular disease, progressive muscular atrophy, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, spinal muscular atrophy | Active, not recruiting | Not stated | 2026-06-15 | NCT03912987 | |
| Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies | Head and Neck Neoplasms, Hemic and Lymphatic Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Connective and Soft Tissue, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Skin and Connective Tissue Diseases, carcinoma, epithelial neoplasm, head and neck squamous cell carcinoma, immune system disorder, immunoproliferative disorder, lymphatic system disorder, lymphoma, lymphoproliferative syndrome, melanocytic neoplasm, melanoma, neoplasm, neuroendocrine neoplasm, primitive neuroectodermal tumor, sarcoma, skin disorder, skin neoplasm, squamous cell carcinoma | Active, not recruiting | Early phase 1 | 2026-05-22 | NCT04541108 | |
| A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease | Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Dyskinesias, Huntington disease, Neurologic Manifestations, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Rare Diseases, Signs and Symptoms, basal ganglia disorder, brain disorder, central nervous system disorder, choreatic disease, cognitive disorder, dementia, hereditary disease, inherited neurodegenerative disorder, movement disorder, nervous system disorder, neurodegenerative disease, psychiatric disorder | Recruiting | Phase 1 / Phase 2 | 2026-05-05 | NCT06826612 | |
| TMS for iEEG Monitoring Recordings | EEG; TMS | Enrolling by invitation | Not applicable | 2026-05-01 | NCT07518745 | |
| A Study of Lu AF82422 in Participants With Multiple System Atrophy | autonomic nervous system disorder, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, multiple system atrophy, nervous system disorder, neurodegenerative disease, primary dysautonomia, pure autonomic failure, synucleinopathy | Active, not recruiting | Phase 2 | 2026-04-13 | NCT05104476 | |
| Mapping LIFU Responses Using iEEG Recordings | Electrodes, Implanted; Low Intensity Focussed Ultrasound | Enrolling by invitation | Not applicable | 2026-04-09 | NCT07518927 | |
| Robotic vs. Open NSM for Early Stage Breast Cancer | Neoplasms by Site, Skin and Connective Tissue Diseases, breast cancer, breast disorder, breast neoplasm, neoplasm, skin disorder | Active, not recruiting | Not applicable | 2026-02-24 | NCT05720039 | |
| Robotic-Assisted da Vinci System Prophylactic Nipple-Sparing Mastectomy | Nipple Sparing Mastectomy | Active, not recruiting | Not applicable | 2025-12-18 | NCT03892980 | |
| Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging) | Prodromal Parkinsons Disease | Recruiting | Phase 2 | 2025-12-05 | NCT07265596 | |
| Bilateral Treatment of Medication Refractory Essential Tremor | central nervous system disorder, essential tremor, movement disorder, nervous system disorder | Active, not recruiting | Not applicable | 2025-05-01 | NCT04112381 | |
| Early Longitudinal Imaging in Parkinson's Progression Markers Initiative Using [¹⁸F] AV-133 and DaTscan™ | Neurologic Manifestations, Parkinson disease, Pathological Conditions, Signs and Symptoms, Sensation Disorders, Signs and Symptoms, anosmia, basal ganglia disorder, brain disorder, central nervous system disorder, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, synucleinopathy | Active, not recruiting | Not stated | 2024-10-31 | NCT04507139 | |
| Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort | Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Huntington disease, basal ganglia disorder, brain disorder, central nervous system disorder, choreatic disease, cognitive disorder, dementia, hereditary disease, inherited neurodegenerative disorder, movement disorder, nervous system disorder, neurodegenerative disease, psychiatric disorder | Recruiting | Not stated | 2024-02-28 | NCT01574053 |