Vaso-Occlusive Crises
Vaso-Occlusive Crises
Explore linked clinical trials. Standard reference: MESH:M00076707232 results · Page 1 of 2
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Hemic and Lymphatic Diseases, Male Urogenital Diseases, Respiration Disorders, Urogenital Diseases, Vaso-Occlusive Crises, acute chest syndrome, acute kidney injury, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, kidney disorder, kidney failure, lung disorder, respiratory system disorder, sickle cell disease, urinary system disorder | Recruiting | Phase 2 | 2026-10-08 | NCT06699849 | |
| A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Sickle Cell Trait, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Phase 3 | 2026-09-28 | NCT06439082 | |
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Vaso-Occlusive Crises, agnosia, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, nervous system disorder, perceptual disorders, sickle cell disease | Not yet recruiting | Phase 4 | 2026-09-18 | NCT07826988 | |
| Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Sickle Cell Trait, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Active, not recruiting | Phase 3 | 2026-09-14 | NCT03814746 | |
| Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Respiration Disorders, Signs and Symptoms, Vaso-Occlusive Crises, acute chest syndrome, agnosia, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, nervous system disorder, perceptual disorders, respiratory system disorder, sickle cell disease | Recruiting | Phase 3 | 2026-09-09 | NCT07274254 | |
| Buprenorphine for the Management of Pain in Children With Sickle Cell Disease | Acute Pain, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Hemoglobin SC Disease, Neurologic Manifestations, Pain, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Not yet recruiting | Phase 1 | 2026-09-02 | NCT07799571 | |
| Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Neurobehavioral Manifestations, Neurologic Manifestations, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Vaso-Occlusive Crises, agnosia, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, nervous system disorder, perceptual disorders, sickle cell disease | Recruiting | Phase 2 | 2026-09-02 | NCT07369024 | |
| Pleuropulmonary Ultrasound Imaging in Patients With Sickle Cell Disease in a Vaso-occlusive Crisis. "ECHODREP" | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Emergencies, Hemic and Lymphatic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Respiration Disorders, Vaso-Occlusive Crises, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell disease | Not yet recruiting | Not stated | 2026-08-24 | NCT07782489 | |
| Hypoxic Red Blood Cells in Sickle Cell Anemia | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Not yet recruiting | Not applicable | 2026-08-17 | NCT06743113 | |
| Standard of Care Comparative Arm of Phase 1/2 Gene Therapy Trial DREPAMIR" in Severe Sickle Cell Disease Patients | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Not yet recruiting | Not applicable | 2026-08-07 | NCT07752043 | |
| Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Phase 2 | 2026-08-05 | NCT07224360 | |
| Virtual Reality for SCD VOC | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Not yet recruiting | Not applicable | 2026-06-29 | NCT07674277 | |
| Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Phase 4 | 2026-06-08 | NCT04657822 | |
| Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Neurologic Manifestations, Pain, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Not applicable | 2026-05-18 | NCT03353584 | |
| A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Hemolysis, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Sickle Cell Trait, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Active, not recruiting | Phase 3 | 2026-04-06 | NCT04624659 | |
| Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Not yet recruiting | Phase 3 | 2026-03-27 | NCT07498309 | |
| Inflammation, Platelets and Sickle Cell Disease | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Embolism and Thrombosis, Hemic and Lymphatic Diseases, Inflammation, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Thromboinflammation, Vaso-Occlusive Crises, anemia, blood coagulation disease, cardiovascular disorder, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease, thrombotic disease, vascular disorder | Active, not recruiting | Not stated | 2026-03-19 | NCT05646888 | |
| Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Emergencies, Hemic and Lymphatic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Schnyder corneal dystrophy, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Not applicable | 2026-03-18 | NCT07188766 | |
| Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Respiration Disorders, Vaso-Occlusive Crises, acute chest syndrome, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, respiratory system disorder, sickle cell disease | Recruiting | Not applicable | 2026-03-10 | NCT07246265 | |
| Optimal Timing of Ketamine Initiation for SCD Pain | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Neurologic Manifestations, Pain, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Not yet recruiting | Phase 3 | 2026-03-09 | NCT07450430 | |
| Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA. | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Phase 1 / Phase 2 | 2026-03-04 | NCT07432867 | |
| Lipid Balance in Adult Sickle Cell Patients | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyslipidemias, Genital Diseases, Hemic and Lymphatic Diseases, Lipid Metabolism Disorders, Male Urogenital Diseases, Nutritional and Metabolic Diseases, Urogenital Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, lung disorder, male reproductive system disorder, metabolic disease, penile disorder, priapism, pulmonary arterial hypertension, pulmonary hypertension, respiratory system disorder, sickle cell disease | Active, not recruiting | Not applicable | 2025-12-10 | NCT05780775 | |
| Outcomes of Vaso-occlusive Crisis in Pediatric Sickle Cell Disease | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Not yet recruiting | Not stated | 2025-10-01 | NCT07200869 | |
| Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease | Chronic Disease, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Attributes, Hemic and Lymphatic Diseases, Neurologic Manifestations, Pain, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Stress Disorders, Traumatic, Vaso-Occlusive Crises, acute stress disorder, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, post-traumatic stress disorder, psychiatric disorder, sickle cell disease | Recruiting | Not applicable | 2025-06-03 | NCT07001631 | |
| Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Inflammation, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Not stated | 2025-06-03 | NCT07001189 |