A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
Recruiting · NCT06439082 · Registry updated 2026-09-28Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE) | Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hemic and Lymphatic Diseases, Sickle Cell Trait, Vaso-Occlusive Crises, anemia, familial hemolytic anemia, hematologic disorder, hemolytic anemia, hereditary disease, inherited hemoglobinopathy, sickle cell disease | Recruiting | Phase 3 | 2026-09-28 | NCT06439082 |
1 results · Page 1 of 1
Organizations
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| Organizations | Linked trials |
|---|---|
| Novartis Pharmaceuticals | 432 |
17 results · Page 1 of 1
Research sites
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| Research sites | City | Country | Linked trials |
|---|---|---|---|
| Augusta University Georgia | Augusta | United States | 8 |
| Childrens Hospital at Montefiore | The Bronx | United States | 1 |
| Childrens National Hospital | Washington D.C. | United States | 10 |
| Ctr for Inherited Blood Disorders | Orange | United States | 1 |
| East Carolina University | Greenville | United States | 144 |
| Norton Children s Hospital | Louisville | United States | 1 |
| Southern Specialty Research | Flowood | United States | 3 |
| Spoknwrdclinicaltrials | Easton | United States | 1 |
| Texas Childrens Cancer and Hematology Center | Houston | United States | 2 |
| The Johns Hopkins University School of Medicine | Baltimore | United States | 4 |
| Thomas Jefferson University Me | Philadelphia | United States | 1 |
| U of TX Health Science Ct | Houston | United States | 4 |
| Uni of Illinois Hospital and HSC | Chicago | United States | 1 |
| University of Alabama | Birmingham | United States | 25 |
| University of Florida | Jacksonville | United States | 15 |
| Wake Forest University Baptist Medical Center | Winston-Salem | United States | 11 |
| WCG Sonar Clinical Research | Riverdale | United States | 1 |