4D Molecular Therapeutics | ClinicalTrials HQ

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Trial	Conditions	Status	Phase	Updated	More info	NCT ID
Phase 3 Study of Intravitreal 4D-150 in Adults With Diabetic Macular Edema (DME) (4D-150-C005)	eye disorder	Recruiting	Phase 3	2026-10-09		NCT07867080
4D-150 in Patients With Diabetic Macular Edema	Diabetes Complications, cardiovascular disorder, diabetes mellitus, diabetic macular edema, diabetic peripheral angiopathy, diabetic retinopathy, endocrine system disorder, eye disorder, retinal disorder, vascular disorder	Active, not recruiting	Phase 2	2026-08-21		NCT05930561
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration	eye disorder, macular degeneration, retinal degeneration, retinal disorder, wet macular degeneration	Recruiting	Phase 1 / Phase 2	2026-08-21		NCT05197270
4D-710 in Adult Patients With Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, Infant, Newborn, Diseases, cystic fibrosis, hereditary disease, lung disorder, pancreas disorder, respiratory system disorder	Recruiting	Phase 2	2026-07-06		NCT05248230
4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration	eye disorder, macular degeneration, retinal degeneration, retinal disorder, wet macular degeneration	Active, not recruiting	Phase 3	2026-06-01		NCT06864988
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration	eye disorder, macular degeneration, retinal degeneration, retinal disorder, wet macular degeneration	Recruiting	Phase 3	2026-04-16		NCT07064759
Dose Escalation Study of Intravitreal 4D-110 in Patients With Choroideremia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Eye Diseases, Hereditary, X-linked disease, choroideremia, eye disorder, hereditary disease, optic choroid disorder, uveal disorder	Active, not recruiting	Phase 1	2025-05-22		NCT04483440
4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)	X-Linked Retinitis Pigmentosa	Active, not recruiting	Phase 1 / Phase 2	2025-03-21		NCT04517149
4D-310 in Adults With Fabry Disease and Cardiac Involvement	Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Cerebral Small Vessel Diseases, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Fabry disease, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lysosomal Storage Diseases, Nervous System, Nutritional and Metabolic Diseases, X-linked disease, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, hereditary disease, inborn errors of metabolism, lysosomal lipid storage disorder, lysosomal storage disease, metabolic disease, nervous system disorder, sphingolipidosis, vascular disorder	Recruiting	Phase 1 / Phase 2	2025-02-21		NCT05629559
An Open-label, Phase 1/2 Trial of Gene Therapy 4D-310 in Adults With Fabry Disease	Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Cerebral Small Vessel Diseases, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Fabry disease, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lysosomal Storage Diseases, Nervous System, Nutritional and Metabolic Diseases, X-linked disease, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, hereditary disease, inborn errors of metabolism, lysosomal lipid storage disorder, lysosomal storage disease, metabolic disease, nervous system disorder, sphingolipidosis, vascular disorder	Active, not recruiting	Phase 1 / Phase 2	2024-04-08		NCT04519749