A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss
A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss
Recruiting · NCT05593497 · Registry updated 2026-10-05Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss | Genital Diseases, Male Urogenital Diseases, Neoplasms by Site, Urogenital Diseases, Urogenital Neoplasms, male reproductive organ cancer, male reproductive system disorder, neoplasm, prostate cancer, prostate disorder | Recruiting | Phase 2 | 2026-10-05 | NCT05593497 |
1 results · Page 1 of 1
Organizations
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| Organizations | Linked trials |
|---|---|
| VA Office of Research and Development | 472 |
9 results · Page 1 of 1
Research sites
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| Research sites | City | Country | Linked trials |
|---|---|---|---|
| James J. Peters VA Medical Center, Bronx, NY | The Bronx | United States | 12 |
| Jesse Brown VA Medical Center, Chicago, IL | Chicago | United States | 16 |
| Michael E. DeBakey VA Medical Center, Houston, TX | Houston | United States | 30 |
| Ralph H. Johnson VA Medical Center, Charleston, SC | Charleston | United States | 25 |
| South Texas Health Care System, San Antonio, TX | San Antonio | United States | 9 |
| St. Louis VA Medical Center John Cochran Division, St. Louis, MO | St Louis | United States | 9 |
| VA Greater Los Angeles Healthcare System, West Los Angeles, CA | West Los Angeles | United States | 35 |
| VA Portland Health Care System, Portland, OR | Portland | United States | 30 |
| VA Puget Sound Health Care System Seattle Division, Seattle, WA | Seattle | United States | 32 |