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DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

Recruiting · NCT05768178 · Registry updated 2025-11-24
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Clinical trials

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TrialConditionsStatusPhaseUpdatedMore infoNCT ID
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.Adnexal Diseases, Blood Protein Disorders, Digestive System Diseases, Digestive System Neoplasms, Erdheim-Chester disease, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Genital Diseases, Head and Neck Neoplasms, Hemic and Lymphatic Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Otorhinolaryngologic Neoplasms, Skin and Connective Tissue Diseases, Thoracic Neoplasms, Thyroid Cancer, Papillary, Urogenital Diseases, Urogenital Neoplasms, adenocarcinoma, bronchial neoplasm, bronchogenic carcinoma, carcinoma, cardiovascular disorder, colonic disorder, colorectal neoplasm, digestive system disorder, digestive system neoplasm, endocrine system disorder, epithelial neoplasm, female reproductive system disorder, female reproductive system neoplasm, glioma, gonadal disorder, hematologic disorder, hematopoietic and lymphoid system neoplasm, hemorrhagic disease, histiocytosis, immune system disorder, immunoproliferative disorder, intestinal disorder, laryngeal disorder, laryngeal neoplasm, lung disorder, lung neoplasm, lymphatic system disorder, lymphoproliferative syndrome, malignant endocrine neoplasm, melanocytic neoplasm, melanoma, monoclonal gammopathy, neoplasm, neuroendocrine neoplasm, neuroepithelial neoplasm, non-Langerhans cell histiocytosis, non-small cell lung carcinoma, otorhinolaryngologic disease, ovarian cancer, ovarian disorder, papillary adenocarcinoma, plasma cell neoplasm, primitive neuroectodermal tumor, rectal disorder, respiratory system disorder, respiratory tract neoplasm, skin disorder, skin neoplasm, thyroid gland disorder, thyroid gland undifferentiated (anaplastic) carcinoma, thyroid tumor, vascular disorder, vascular hemostatic diseaseRecruitingPhase 2 / Phase 32025-11-24NCT05768178

5 results · Page 1 of 1

Organizations

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OrganizationsLinked trials
Cancer Research UK59
Hoffmann-La Roche280
Royal Marsden NHS Foundation Trust89
University of Birmingham75
University of Manchester85

16 results · Page 1 of 1

Research sites

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Research sitesCityCountryLinked trials
Addenbrooke's HospitalCambridgeUnited Kingdom8
Belfast City HospitalBelfastUnited Kingdom24
Bristol Haematology and Oncology CentreBristolUnited Kingdom26
Churchill HospitalOxfordUnited Kingdom43
Clatterbridge Cancer CentreMetropolitan Borough of WirralUnited Kingdom14
Freeman HospitalNewcastleUnited Kingdom14
Guy's HospitalLondonUnited Kingdom44
Leicester Royal InfirmaryLeicesterUnited Kingdom35
Southampton General HospitalSouthamptonUnited Kingdom56
The Beatson HospitalGlasgowUnited Kingdom8
The Christie HospitalManchesterUnited Kingdom27
University College London HospitalLondonUnited Kingdom20
University Hospital BirminghamBirminghamUnited Kingdom8
Velindre Cancer CentreCardiffUnited Kingdom32
Western General HospitalEdinburghUnited Kingdom52
Weston Park HospitalSheffieldUnited Kingdom17