A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
Recruiting · NCT06682793 · Registry updated 2025-09-09Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression | Digestive System Diseases, Digestive System Neoplasms, Female Urogenital Diseases, Female Urogenital Diseases and Pregnancy Complications, Head and Neck Neoplasms, Male Urogenital Diseases, Neoplasms by Histologic Type, Neoplasms by Site, Skin and Connective Tissue Diseases, Thoracic Neoplasms, Urogenital Diseases, Urogenital Neoplasms, adenocarcinoma, benign urinary system neoplasm, breast disorder, breast neoplasm, bronchial neoplasm, bronchogenic carcinoma, cancer, carcinoma, colonic disorder, colonic neoplasm, colorectal adenocarcinoma, colorectal cancer, colorectal carcinoma, colorectal neoplasm, digestive system disorder, digestive system neoplasm, epithelial neoplasm, head and neck squamous cell carcinoma, intestinal disorder, kidney cancer, kidney disorder, lung cancer, lung disorder, lung neoplasm, malignant colon neoplasm, neoplasm, non-small cell lung carcinoma, rectal cancer, rectal disorder, rectal neoplasm, renal cell carcinoma, respiratory system disorder, respiratory tract neoplasm, skin disorder, squamous cell carcinoma, triple-negative breast carcinoma, urinary system disorder | Recruiting | Phase 1 / Phase 2 | 2025-09-09 | NCT06682793 |
1 results · Page 1 of 1
Organizations
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| Organizations | Linked trials |
|---|---|
| A2 Biotherapeutics Inc. | 5 |
10 results · Page 1 of 1
Research sites
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| Research sites | City | Country | Linked trials |
|---|---|---|---|
| Banner Md Anderson Cancer Center | Gilbert | United States | 121 |
| Fred Hutch Cancer Center | Seattle | United States | 12 |
| Mayo Clinic | Rochester | United States | 664 |
| Mayo Clinic | Jacksonville | United States | 122 |
| Moffitt Cancer Center | Tampa | United States | 2 |
| NYU Langone Health | New York | United States | 403 |
| The Ohio State University | Columbus | United States | 191 |
| UCLA Medical Center | Los Angeles | United States | 4 |
| UCSD Moores Cancer Center | La Jolla | United States | 20 |
| Washington University | St Louis | United States | 182 |