Leukoencephalopathies
Leukoencephalopathies
Explore linked clinical trials. Standard reference: MESH:M0529130111 results · Page 1 of 5
Clinical trials
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| Trial | Conditions | Status | Phase | Updated | More info | NCT ID |
|---|---|---|---|---|---|---|
| Natural History and Genotype-Phenotype Correlations in Mitochondrial Leukoencephalopathies | Leukoencephalopathies, Nutritional and Metabolic Diseases, brain disorder, central nervous system disorder, inborn mitochondrial metabolism disorder, metabolic disease, nervous system disorder | Recruiting | Not stated | 2026-10-09 | NCT07868796 | |
| The Erlanger Stroke Registry (ESPro) is the Only Ongoing Prospective Population-based Stroke Registry in Germany, Started in 1994. ESPro Includes All Hospitalized and Non-hospitalized Patients With Stroke in the Community of Erlangen (120.000 Inhabitants), With a Long-life Follow-up. | Arterial Occlusive Diseases, Embolism and Thrombosis, Hemorrhage, Infarction, Intracranial Embolism and Thrombosis, Intracranial Hemorrhages, Leukoencephalopathies, Necrosis, Pathologic Processes, Pathological Conditions, Signs and Symptoms, Thromboembolism, arteriosclerosis disorder, brain disorder, brain infarction, brain ischemia, cardiovascular disorder, central nervous system disorder, cerebral infarction, cerebrovascular disorder, cognitive disorder, dementia, intracerebral hemorrhage, intracranial arterial disease, intracranial arteriosclerosis, intracranial thrombosis, ischemic disease, multi-infarct dementia, nervous system disorder, psychiatric disorder, stroke disorder, vascular dementia, vascular disorder | Recruiting | Not stated | 2026-10-02 | NCT07771335 | |
| Rocket Study: A Study to Characterize Biomarkers and Disease Progression in Participants With Pelizaeus-Merzbacher Disease | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Nutritional and Metabolic Diseases, Pelizaeus-Merzbacher spectrum disorder, X-linked disease, brain disorder, central nervous system disorder, demyelinating disease, hereditary disease, inborn errors of metabolism, metabolic disease, nervous system disorder | Recruiting | Not stated | 2026-10-02 | NCT05659901 | |
| Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients | Alzheimer disease, Arterial Occlusive Diseases, Cognition Disorders, Cognitive Decline, Cognitive Dysfunction, Leukoencephalopathies, arteriosclerosis disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, intracranial arterial disease, intracranial arteriosclerosis, nervous system disorder, neurodegenerative disease, psychiatric disorder, stroke disorder, tauopathy, vascular dementia, vascular disorder | Active, not recruiting | Not applicable | 2026-10-02 | NCT04337255 | |
| An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease | Leukoencephalopathies, brain disorder, central nervous system disorder, leukoencephalopathy with vanishing white matter 1, nervous system disorder, neurodegenerative disease | Recruiting | Phase 1 / Phase 2 | 2026-09-24 | NCT05757141 | |
| Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers | Alzheimer disease, Arterial Occlusive Diseases, Chronic Disease, Cognition Disorders, Cognitive Dysfunction, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Creutzfeldt Jacob disease, Disease Attributes, Dyskinesias, Frontotemporal Lobar Degeneration, Huntington disease, Infections, Leukoencephalopathies, Lewy body dementia, Mixed Dementias, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, TDP-43 proteinopathy, arteriosclerosis disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, central nervous system infectious disorder, cerebrovascular disorder, choreatic disease, cognitive disorder, dementia, hereditary disease, inherited neurodegenerative disorder, intracranial arterial disease, intracranial arteriosclerosis, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, prion disease, proteostasis deficiencies, psychiatric disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Active, not recruiting | Not applicable | 2026-09-21 | NCT05596760 | |
| Evaluation of Cerogrin for Auricular Vagus Nerve Stimulation in Vascular Dementia or Vascular Mild Cognitive Impairment | Arterial Occlusive Diseases, Cognition Disorders, Cognitive Dysfunction, Leukoencephalopathies, Mild Cognitive Impairment, arteriosclerosis disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, intracranial arterial disease, intracranial arteriosclerosis, nervous system disorder, psychiatric disorder, vascular dementia, vascular disorder | Active, not recruiting | Not applicable | 2026-09-18 | NCT07149038 | |
| Pulsed Electromagnetic Field Treatment With Dementia Patients | Alzheimer disease, Arterial Occlusive Diseases, Leukoencephalopathies, Lewy body dementia, arteriosclerosis disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, intracranial arterial disease, intracranial arteriosclerosis, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, psychiatric disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Recruiting | Not applicable | 2026-09-17 | NCT06862557 | |
| Home Exercise for Individuals With Neurodegenerative Disease | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Pathological Conditions, Signs and Symptoms, Peroxisomal Disorders, Signs and Symptoms, X-linked disease, adrenal gland disorder, adrenocortical insufficiency, adrenoleukodystrophy, adrenomyeloneuropathy, atactic disorder, non-human animal, brain disorder, central nervous system disorder, cerebellar ataxia, cerebellar disorder, demyelinating disease, endocrine system disorder, hereditary disease, inborn errors of metabolism, inherited neurodegenerative disorder, intellectual disability, leukodystrophy, leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome, metabolic disease, nervous system disorder, neurodegenerative disease | Recruiting | Not applicable | 2026-09-16 | NCT05443906 | |
| The BRAIN App (Phase 2 SBIR) | Alzheimer disease, Arterial Occlusive Diseases, Leukoencephalopathies, arteriosclerosis disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, intracranial arterial disease, intracranial arteriosclerosis, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy, vascular dementia, vascular disorder | Recruiting | Not applicable | 2026-09-15 | NCT06298474 | |
| Making Connections Thru Music | Alzheimer disease, Arterial Occlusive Diseases, Leukoencephalopathies, arteriosclerosis disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, intracranial arterial disease, intracranial arteriosclerosis, nervous system disorder, neurodegenerative disease, psychiatric disorder, tauopathy, vascular dementia, vascular disorder | Recruiting | Not applicable | 2026-09-15 | NCT06079216 | |
| Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY | Arterial Occlusive Diseases, Cognition Disorders, Cognitive Dysfunction, Hemorrhage, Intracranial Hemorrhages, Leukoencephalopathies, Mild Cognitive Impairment, Pathologic Processes, Pathological Conditions, Signs and Symptoms, arteriosclerosis disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, intracerebral hemorrhage, intracranial arterial disease, intracranial arteriosclerosis, ischemic stroke, nervous system disorder, psychiatric disorder, stroke disorder, subarachnoid hemorrhage, vascular dementia, vascular disorder | Recruiting | Not stated | 2026-09-14 | NCT04916210 | |
| Long-term Follow-up of Participants With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Peroxisomal Disorders, X-linked disease, adrenal gland disorder, adrenocortical insufficiency, adrenoleukodystrophy, brain disorder, central nervous system disorder, demyelinating disease, endocrine system disorder, hereditary disease, inborn errors of metabolism, inherited neurodegenerative disorder, intellectual disability, metabolic disease, nervous system disorder | Active, not recruiting | Not stated | 2026-09-14 | NCT02698579 | |
| Florida Cerebrovascular Disease Biorepository and Genomics Center | Arterial Occlusive Diseases, Cardiovascular Abnormalities, Cerebral Small Vessel Diseases, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Embolism and Thrombosis, Fistula, Hemorrhage, Hypoxia, Hypoxia, Brain, Infarction, Intracranial Embolism and Thrombosis, Intracranial Hemorrhages, Leukoaraiosis, Leukoencephalopathies, Moyamoya disease, Necrosis, Pathologic Processes, Pathological Conditions, Anatomical, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, Signs and Symptoms, Respiratory, Subarachnoid Hemorrhage, Aneurysmal, Thromboembolism, Vascular Fistula, arteriosclerosis disorder, arteriovenous hemangioma/malformation, brain disorder, brain hypoxia - ischemia, brain infarction, brain ischemia, cardiovascular disorder, carotid artery disorder, central nervous system disorder, cerebral arterial disease, cerebral infarction, cerebrovascular disorder, cognitive disorder, congenital arteriovenous fistula, dementia, fibromuscular dysplasia, hereditary disease, intracerebral hemorrhage, intracranial arterial disease, intracranial arteriosclerosis, intracranial thrombosis, ischemic disease, ischemic stroke, nervous system disorder, psychiatric disorder, reversible cerebral vasoconstriction syndrome, stroke disorder, subarachnoid hemorrhage, transient ischemic attack, vascular dementia, vascular disorder, vascular malformation | Active, not recruiting | Not stated | 2026-09-03 | NCT05491980 | |
| UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, GM2 gangliosidosis, Gangliosidoses, Hemic and Lymphatic Diseases, Hereditary Central Nervous System Demyelinating Diseases, Krabbe disease, Leukoencephalopathies, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lysosomal Storage Diseases, Nervous System, Mannosidase Deficiency Diseases, Neurobehavioral Manifestations, Neurologic Manifestations, Neuronal Ceroid-Lipofuscinoses, Niemann-Pick disease, Niemann-Pick disease type A, Nutritional and Metabolic Diseases, Pelizaeus-Merzbacher spectrum disorder, Peroxisomal Disorders, Sandhoff disease, Skin and Connective Tissue Diseases, Sulfatidosis, Tay-Sachs disease, X-linked disease, adrenal gland disorder, adrenocortical insufficiency, adrenoleukodystrophy, alpha-mannosidosis, brain disorder, central nervous system disorder, connective tissue disorder, cutaneous mucinosis, demyelinating disease, endocrine system disorder, hereditary disease, histiocytosis, inborn carbohydrate metabolic disorder, inborn errors of metabolism, inherited neurodegenerative disorder, intellectual disability, juvenile neuronal ceroid lipofuscinosis, lymphatic system disorder, lysosomal lipid storage disorder, lysosomal storage disease, metabolic disease, metachromatic leukodystrophy, mucopolysaccharidosis, mucopolysaccharidosis type 2, nervous system disorder, neurodegenerative disease, non-Langerhans cell histiocytosis, sphingolipidosis | Recruiting | Phase 1 | 2026-09-03 | NCT02254863 | |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) | Alzheimer disease, Arterial Occlusive Diseases, Cognition Disorders, Cognitive Dysfunction, Frontotemporal Lobar Degeneration, Leukoencephalopathies, Lewy body dementia, Nutritional and Metabolic Diseases, Pathologic Processes, Pathological Conditions, Signs and Symptoms, TDP-43 proteinopathy, arteriosclerosis disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, disease, frontotemporal dementia, intracranial arterial disease, intracranial arteriosclerosis, metabolic disease, movement disorder, nervous system disorder, neurodegenerative disease, parkinsonian disorder, proteostasis deficiencies, psychiatric disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Not yet recruiting | Not stated | 2026-09-02 | NCT07200739 | |
| Lentiviral Hematopoietic Stem Cell Gene Therapy for MLD | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lysosomal Storage Diseases, Nervous System, Nutritional and Metabolic Diseases, Sulfatidosis, brain disorder, central nervous system disorder, demyelinating disease, hereditary disease, inborn errors of metabolism, lysosomal lipid storage disorder, lysosomal storage disease, metabolic disease, metachromatic leukodystrophy, nervous system disorder, sphingolipidosis | Not yet recruiting | Not applicable | 2026-09-01 | NCT07046338 | |
| IT and IV Lentiviral Gene Therapy for X-ALD | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Peroxisomal Disorders, X-linked disease, adrenal gland disorder, adrenocortical insufficiency, adrenoleukodystrophy, brain disorder, central nervous system disorder, demyelinating disease, endocrine system disorder, hereditary disease, inborn errors of metabolism, inherited neurodegenerative disorder, intellectual disability, metabolic disease, nervous system disorder | Not yet recruiting | Not applicable | 2026-09-01 | NCT03727555 | |
| Direct Lentiviral Injection Gene Therapy for MLD | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Lysosomal Storage Diseases, Nervous System, Nutritional and Metabolic Diseases, Sulfatidosis, brain disorder, central nervous system disorder, demyelinating disease, hereditary disease, inborn errors of metabolism, lysosomal lipid storage disorder, lysosomal storage disease, metabolic disease, metachromatic leukodystrophy, nervous system disorder, sphingolipidosis | Not yet recruiting | Not applicable | 2026-09-01 | NCT03725670 | |
| Natural History Study of Progressive Multifocal Leukoencephalopathy (PML) | AIDS, Blood-Borne Infections, CNS demyelinating autoimmune disease, DNA Virus Infections, Encephalitis, Viral, Genital Diseases, HIV infectious disease, Infections, Leukoencephalopathies, Neuroinflammatory Diseases, RNA Virus Infections, Slow Virus Diseases, Urogenital Diseases, autoimmune disease, autoimmune disorder of the nervous system, brain disorder, central nervous system disorder, central nervous system infectious disorder, demyelinating disease, encephalitis, immune reconstitution inflammatory syndrome, immune system disorder, inborn error of immunity, infectious disease, infectious encephalitis, lentivirus infection, multiple sclerosis, nervous system disorder, polyomavirus infectious disease, progressive multifocal leukoencephalopathy, sexually transmitted disease, uterine carcinosarcoma, viral infection of central nervous system, viral infectious disease, viral sexually transmitted disease | Recruiting | Not stated | 2026-08-31 | NCT01730131 | |
| Quality of Life in Women With X-linked Adrenoleukodystrophy | Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Neurobehavioral Manifestations, Neurologic Manifestations, Nutritional and Metabolic Diseases, Peroxisomal Disorders, X-linked disease, adrenal gland disorder, adrenocortical insufficiency, adrenoleukodystrophy, brain disorder, central nervous system disorder, demyelinating disease, endocrine system disorder, hereditary disease, inborn errors of metabolism, inherited neurodegenerative disorder, intellectual disability, metabolic disease, nervous system disorder | Recruiting | Not stated | 2026-08-27 | NCT04675749 | |
| A Study to Evaluate the Safety and Efficacy of Zilganersen (ION373) in Patients With Alexander Disease (AxD) | Alexander disease, Brain Diseases, Metabolic, Brain Diseases, Metabolic, Inborn, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Hereditary Central Nervous System Demyelinating Diseases, Leukoencephalopathies, Nutritional and Metabolic Diseases, brain disorder, central nervous system disorder, demyelinating disease, hereditary disease, inborn errors of metabolism, inherited neurodegenerative disorder, metabolic disease, nervous system disorder, neurodegenerative disease | Active, not recruiting | Phase 3 | 2026-08-21 | NCT04849741 | |
| ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing | Alzheimer disease, Apnea, Arterial Occlusive Diseases, Cognition Disorders, Cognitive Dysfunction, Dyssomnias, Leukoencephalopathies, Lewy body dementia, Mild Cognitive Impairment, Mixed Dementias, Respiration Disorders, Sleep Disorders, Intrinsic, arteriosclerosis disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, cognitive disorder, dementia, intracranial arterial disease, intracranial arteriosclerosis, movement disorder, nervous system disorder, neurodegenerative disease, obstructive sleep apnea syndrome, parkinsonian disorder, psychiatric disorder, respiratory system disorder, sleep apnea syndrome, sleep-wake disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Recruiting | Not applicable | 2026-08-20 | NCT04335994 | |
| Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study | CNS demyelinating autoimmune disease, Leukoencephalopathies, Pathologic Processes, Pathological Conditions, Signs and Symptoms, autoimmune disease, autoimmune disorder of the nervous system, brain disorder, central nervous system disorder, demyelinating disease, immune system disorder, multiple sclerosis, nervous system disorder | Recruiting | Not applicable | 2026-08-17 | NCT07759115 | |
| Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study | Alzheimer disease, Arterial Occlusive Diseases, Cognition Disorders, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyskinesias, Frontotemporal Lobar Degeneration, Huntington disease, Leukoencephalopathies, Lewy body dementia, Neurologic Manifestations, Nutritional and Metabolic Diseases, Ocular Motility Disorders, Parkinson disease, Pathological Conditions, Signs and Symptoms, Signs and Symptoms, TDP-43 proteinopathy, amyotrophic lateral sclerosis, arteriosclerosis disorder, autonomic nervous system disorder, basal ganglia disorder, brain disorder, cardiovascular disorder, central nervous system disorder, cerebrovascular disorder, choreatic disease, cognitive disorder, corticobasal degeneration disorder, cranial nerve neuropathy, dementia, eye disorder, frontotemporal dementia, hereditary disease, inherited neurodegenerative disorder, intracranial arterial disease, intracranial arteriosclerosis, metabolic disease, motor neuron disorder, movement disorder, multiple system atrophy, nervous system disorder, neurodegenerative disease, neuromuscular disease, ophthalmoplegia, palsy, parkinsonian disorder, primary dysautonomia, progressive supranuclear palsy, proteostasis deficiencies, psychiatric disorder, spinal cord disorder, synucleinopathy, tauopathy, vascular dementia, vascular disorder | Active, not recruiting | Not stated | 2026-08-10 | NCT06209515 |